Imperial College London

Dr Jake Dunning

Faculty of MedicineNational Heart & Lung Institute

Honorary Senior Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3853j.dunning Website

 
 
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Assistant

 

Ms Gale Lewis +44 (0)20 7594 0944

 
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Location

 

370Norfolk PlaceSt Mary's Campus

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Summary

 

Summary

 

Dr Jake Dunning is a Senior Research Fellow in the Epidemic diseases Research Group Oxford (ERGO) at the University of Oxford, and Honorary Consultant in Infectious Diseases at the Royal Free Hospital, London. At Imperial, he is Honorary Clinical Senior Lecturer in the Respiratory Infections Section at the National Heart and Lung Institute, which is the academic partner in the NIHR Health Protection Research Unit in Respiratory Infections. Jake is also an honorary consultant at Public Health England, and an Honorary Clinical Associate Professor at University College London.

Jake graduated with honours from Imperial College School of Medicine in 2001, having originally enrolled to read medicine at Charing Cross and Westminster Medical School in 1995. He obtained an intercalated BSc in Pharmacology during his undergraduate medical studies. As a postgraduate, he specialised in infectious diseases and general internal medicine, working at major teaching hospitals and specialist centres across London. 

From 2009 to 2013, Jake was the CRI Clinical Research Fellow for the Mechanisms of Severe Acute Influenza Consortium (MOSAIC) study, which was supported by a joint award from the Wellcome Trust and the Medical Research Council. His PhD was supervised by Professors Peter Openshaw and Jonathan Weber, and his thesis focussed on host gene expression profiling and immune mediator responses in patients with severe influenza and other respiratory infections. Jake was also a visiting researcher at the Division of Immunoregulation, MRC National Institute for Medical Research, where he worked with the MOSAIC transcriptomics lead, Professor Anne O'Garra.

Between October 2014 and October 2015, Jake was Lead Clinician and a Co-Investigator for the Rapid Assessment of Potential Interventions and Drugs for Ebola (RAPIDE) clinical trials of potential treatments for Ebola virus disease in West Africa. These unique trials were led by Prof Peter Horby, Director of ERGO. Jake has worked in seven Ebola Treatment Centres across Sierra Leone, Liberia and Guinea, and also has experience of caring for viral haemorrhagic fever patients at the Royal Free Hospital's High Level Isolation Unit, where he is the Deputy Lead.

Jake is an active member of the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC), a global initiative to improve outbreak research. Working with ISARIC and the World Health Organization, he has contributed to the development of standardised, open-access study protocols and research tools; these are now being used in the UK and globally to study COVID-19. He is experienced in setting-up and conducting observational studies and clinical trials during outbreaks and epidemics, in both resource-rich and resource-limited settings. 

Between 2015 and 2021, Jake was a consultant at Public Health England. His roles included Medical Virology Consultant to the Respiratory Virus Unit, Head of the Enteric Virus Unit, and latterly, Head of Emerging Infections and Zoonoses. He has been a National Incident Director for a variety of public health incidents, including COVID-19, Ebola, Lassa fever, monkeypox, MERS, and Zika virus. Between 2016 and 2018, he was also Deputy Programme Director for High Consequence Infectious Diseases at NHS England, and he helped commission the HCID clinical treatment centre networks.

In April 2021, Jake left PHE to re-join ERGO at the University of Oxford. His current focus is global, patient-focussed research and clinical trials of potential treatments for emerging and high consequence infectious diseases. He retains an honorary consultant position at PHE, where he works on COVID-19 and monkeypox research, and is a theme co-lead in the NIHR HPRU for Emerging and Zoonotic Infections. He contributes to national and international guidelines for a variety of infectious diseases and is a member of the WHO Clinical Guidelines Group for COVID-19 and MERS. 

Jake continues to work with Peter Openshaw and colleagues at Imperial, investigating immune responses to common and novel respiratory viruses. Jake also co-leads, with Professor Ajit Lalvani, the NIHR-funded Assessment of Transmission and Contagiousness of COVID-19 in Contacts (ATACCC) study.

Clinical Interests

Ebola virus disease and other viral haemorrhagic fevers

Pandemic and severe influenza

COVID-19, MERS-CoV infection and other viral causes of SARI

Emerging, zoonotic and high consequence infectious diseases

Enteric viruses

Preparedness, response and resilience for high consequence infectious diseases

General infectious diseases and tropical medicine

Research Interests

Clinical characterisation of emerging and high consequence infectious diseases

Global clinical trials of potential therapies for high consequence infectious diseases

Clinical characterisation and mechanisms of severity in COVID-19

Transmission of SARS-CoV-2 and other respiratory viruses, and how to prevent it

Soluble immune mediator and transcriptomic profiling in influenza and SARI

Mechanisms of pathogenesis in influenza and other acute respiratory viral infections

Global research preparedness, response and resilience for outbreaks and emerging infections

Follow Jake on Twitter @OutbreakJake

 

Selected Publications

Journal Articles

Bloom CI, Drake TM, Docherty AB, et al., 2021, Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK, The Lancet Respiratory Medicine, Vol:9, ISSN:2213-2600, Pages:699-711

Majumdar M, Celma C, Pegg E, et al., 2021, Detection and Typing of Human Enteroviruses from Clinical Samples by Entire-Capsid Next Generation Sequencing, Viruses-Basel, Vol:13, ISSN:1999-4915

Thwaites RS, Sanchez Sevilla Uruchurtu A, Siggins MK, et al., 2021, Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19, Science Immunology, Vol:6, ISSN:2470-9468, Pages:1-17

Shrotri M, Harris R, Rodger A, et al., 2021, Persistence of SARS-CoV-2 N-Antibody Response in Healthcare Workers, London, UK, Emerging Infectious Disease Journal, Vol:27, ISSN:1080-6059

Bloom C, Tom D, Docherty A, et al., Risk of adverse outcomes in patients with underlying respiratory conditions hospitalised with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: a national, multicentre prospective cohort, The Lancet Respiratory Medicine, ISSN:2213-2600

Zhao H, ParryFord F, Dabrera G, et al., 2020, Six-year experience of detection and investigation of possible Middle East Respiratory Syndrome coronavirus cases, England, 2012-2018., Public Health, Vol:189, Pages:141-143

Moore G, Rickard H, Stevenson D, et al., 2020, Detection of SARS-CoV-2 within the healthcare environment: a multicentre study conducted during the first wave of the COVID-19 outbreak in England, Journal of Hospital Infection, ISSN:0195-6701

Celma CC, Beard S, Douglas A, et al., 2020, Retrospective analysis on confirmation rates for referred positive rotavirus samples in England, 2016 to 2017: implications for diagnosis and surveillance, Eurosurveillance, Vol:25, ISSN:1025-496X, Pages:1-8

Moore SC, Penrice-Randall R, Alruwaili M, et al., 2020, Amplicon-based detection and sequencing of SARS-CoV-2 in nasopharyngeal swabs from patients with COVID-19 and identification of deletions in the viral genome that encode proteins involved in interferon antagonism, Viruses-Basel, Vol:12, ISSN:1999-4915, Pages:1-16

Knight SR, Ho A, Pius R, et al., 2020, Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score, Bmj, Vol:370, ISSN:1759-2151

Lamontagne FCC, Agoritsas T, Macdonald H, et al., 2020, A living WHO guideline on drugs for covid-19, Bmj, Vol:370

Mauldin MR, McCollum AM, Nakazawa YJ, et al., 2020, Exportation of Monkeypox Virus From the African Continent, Journal of Infectious Diseases, ISSN:0022-1899

Brown C, Clare K, Chand M, et al., 2020, Snapshot PCR surveillance for SARS-CoV-2 in hospital staff in England, Journal of Infection, Vol:81, ISSN:0163-4453, Pages:427-434

Swann OV, Holden KA, Turtle L, et al., 2020, Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study, Bmj, Vol:370, Pages:1-15

WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection, 2020, A minimal common outcome measure set for COVID-19 clinical research., Lancet Infect Dis, Vol:20, Pages:e192-e197

Dunning J, Thwaites RS, Openshaw PJM, 2020, Seasonal and pandemic influenza: 100 years of progress, still much to learn, Mucosal Immunology, Vol:13, ISSN:1935-3456, Pages:566-573

ISARIC clinical characterisation group, 2020, Global outbreak research: harmony not hegemony., Lancet Infect Dis, Vol:20, Pages:770-772

Gower CM, Dunning J, Nawaz S, et al., 2020, Vaccine-derived rotavirus strains in infants in England., Arch Dis Child, Vol:105, Pages:553-557

Docherty AB, Harrison EM, Green CA, et al., 2020, Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study, Bmj, Vol:369, ISSN:1759-2151, Pages:1-12

Vaughan A, Aarons E, Astbury J, et al., 2020, Human-to-human transmission of monkeypox virus, United Kingdom, October 2018., Emerging Infectious Diseases, Vol:26, ISSN:1080-6040, Pages:782-785

Scott JT, Sharma R, Meredith LW, et al., 2020, Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease: plasma concentrations exceed target levels, with drug accumulation in the most severe patients, Ebiomedicine, ISSN:2352-3964, Pages:102601-102601

Jha A, Dunning J, Tunstall T, et al., 2019, Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza, European Respiratory Journal, Vol:54, ISSN:0903-1936

Thornton AC, Parry-Ford F, Tessier E, et al., 2019, Human exposures to H5N6 Avian influenza, England, 2018, Journal of Infectious Diseases, ISSN:0022-1899

Mich V, Pho Y, Bory S, et al., 2019, Using research to prepare for outbreaks of severe acute respiratory infection, Bmj Global Health, Vol:4, ISSN:2059-7908

The United Kingdom Acute Flaccid Paralysis A F P Task Force, Ramsay M, Dunning J, et al., 2019, An increase in reports of acute flaccid paralysis (AFP) in the United Kingdom, 1 January 2018–21 January 2019: early findings, Eurosurveillance, Vol:24, ISSN:1560-7917

Bubba L, Broberg EK, Jasir A, et al., 2019, Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study, Lancet Infectious Diseases, ISSN:1473-3099

Broberg EK, Simone B, Jansa J, et al., 2018, Upsurge in echovirus 30 detections in five EU/EEA countries, April to September, 2018, Eurosurveillance, Vol:23, ISSN:1560-7917

Vaughan A, Aarons E, Astbury J, et al., 2018, Two cases of monkeypox imported to the United Kingdom, September 2018, Eurosurveillance, Vol:23, ISSN:1025-496X, Pages:1-5

Dunning J, Blankley S, Hoang LT, et al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, Nature Immunology, Vol:19, ISSN:1529-2916, Pages:625-635

Rojek AM, Dunning J, Leliogdowicz A, et al., 2017, Regulatory and operational complexities of conducting a clinical treatment trial during an Ebola Virus Disease epidemic, Clinical Infectious Diseases, Vol:66, ISSN:1058-4838, Pages:1454-1457

Dunning J, Ortiz JR, Uyeki TM, 2017, Avian influenza A(H7N9) virus infection, Bmj Best Practice

Salam AP, Rojek A, Dunning J, et al., 2017, Clinical trials of therapeutics for the prevention of congenital zika virus disease: Challenges and potential solutions, Annals of Internal Medicine

Cole SL, Dunning J, Kok WL, et al., 2017, M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza., Jci Insight, Vol:2, ISSN:2379-3708

Rojek A, Horby P, Dunning J, 2017, Insights from clinical research completed during the west Africa Ebola virus disease epidemic, Lancet Infectious Diseases, ISSN:1473-3099

Dunning J, Kennedy SB, Antierens A, et al., 2016, Experimental treatment of Ebola virus disease with brincidofovir, PLOS One, Vol:11, ISSN:1932-6203

Dunning J, Sahr F, Rojek A, et al., 2016, Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial, PLOS Medicine, Vol:13, ISSN:1549-1277

Arias A, Watson SJ, Asogun D, et al., 2016, Rapid outbreak sequencing of Ebola virus in Sierra Leone identifies transmission chains linked to sporadic cases, Virus Evolution, Vol:2, ISSN:2057-1577

Habibi MS, Jozwik A, Makris S, et al., 2015, Impaired antibody-mediated protection and defective IgA B cell memory in experimental infection of adults with respiratory syncytial virus, American Journal of Respiratory and Critical Care Medicine, Vol:191, ISSN:1535-4970

Dunning J, Fischer W, 2014, Ebola: the battle plan must include specific treatments, The Lancet

Dunning J, Baillie JK, Cao B, et al., 2014, Antiviral combinations for severe influenza, Lancet Infectious Diseases, Vol:14, ISSN:1473-3099, Pages:1259-1270

Elderfield RA, Watson SJ, Godlee A, et al., 2014, Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom, Journal of Virology, Vol:88, ISSN:0022-538X, Pages:13269-13283

Dunning JW, Merson L, Rohde GGU, et al., 2014, Open source clinical science for emerging infections, Lancet Infectious Diseases, Vol:14, ISSN:1473-3099, Pages:8-9

Everitt AR, Clare S, Pertel T, et al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza., Nature, Vol:484, Pages:519-523

Openshaw PJM, Dunning J, 2010, Influenza vaccination: lessons learned from the pandemic (H1N1) 2009 influenza outbreak, Mucosal Immunology, Vol:3, ISSN:1933-0219, Pages:422-424

Dunning J, Openshaw PJM, 2010, Impact of the 2009 influenza pandemic, Thorax, Vol:65, ISSN:0040-6376, Pages:471-472

Conference

Samanta R, Dunning J, Taylor A, et al., 2020, Severe Respiratory Failure in Adult Influenza Infection Is Characterised by Mechanisms Relating to Pulmonary Endothelial Leak and Interferon Gamma Induced Translational Silencing, International Conference of the American-Thoracic-Society (ATS), AMER THORACIC SOC, ISSN:1073-449X

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