Imperial College London

DrJoseCortes Lopez

Faculty of EngineeringDepartment of Bioengineering

Research Associate



+44 (0)7944 338 144j.e.corteslopez Website




B-122Bessemer BuildingSouth Kensington Campus




Selected Publications

Journal Articles

Lachowski D, Matellan C, Gopal S, et al., 2022, Substrate stiffness-driven membrane tension modulates vesicular trafficking via caveolin-1., ACS Nano, Vol:16, ISSN:1936-0851, Pages:4322-4337

Lachowski D, Cortes Lopez J, Matellan C, et al., 2020, G protein-coupled estrogen receptor regulates actin cytoskeleton dynamics to impair cell polarization, Frontiers in Cell and Developmental Biology, Vol:8, ISSN:2296-634X

Chronopoulos A, Thorpe SD, Cortes E, et al., 2020, Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway, Nature Materials, Vol:19, ISSN:1476-1122, Pages:669-678

Rice A, Cortes Lopez JE, Lachowski D, et al., 2020, GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA, Cancers, Vol:12, ISSN:2072-6694

Lachowski D, Cortes E, Rice A, et al., 2019, Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis, Scientific Reports, Vol:9, ISSN:2045-2322

Cortes E, Lachowski D, Rice A, et al., 2019, Retinoic acid receptor-β is downregulated in hepatocellular carcinoma and cirrhosis and its expression inhibits myosin-driven activation and durotaxis in hepatic stellate cells, Hepatology, Vol:69, ISSN:0270-9139, Pages:785-802

Cortes E, Lachowski D, Robinson B, et al., 2019, Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival, EMBO Reports, Vol:20, ISSN:1469-221X

Cortes E, Sarper M, Robinson B, et al., 2019, GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment, EMBO Reports, Vol:20, ISSN:1469-221X

Cortes E, Lachowski D, Rice A, et al., 2018, Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor, Oncogene, Vol:38, ISSN:0950-9232, Pages:2910-2922

Haining AWM, Rahikainen R, Cortes E, et al., 2018, Mechanotransduction in talin through the interaction of the R8 domain with DLC1, PLOS Biology, Vol:16, ISSN:1544-9173, Pages:1-20

Lachowski D, Cortes E, Robinson B, et al., 2018, FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis, The FASEB Journal, Vol:32, ISSN:0892-6638, Pages:1099-1107

Rice AJ, Cortes E, Lachowski D, et al., 2017, Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells, Oncogenesis, Vol:6, ISSN:2157-9024, Pages:e352-e352

Lachowski D, Cortes E, Pink D, et al., 2017, Substrate rigidity controls activation and durotaxis in pancreatic stellate cells, Scientific Reports, Vol:7, ISSN:2045-2322

Lachowski D, Cortes E, Robinson BK, et al., 2016, Assaying the rigidity guided migration of human tumour stromal myofibroblasts (TSMs) on polyacrylamide substrates mimicking the healthy and fibrotic tissue transition boundary, Convergent Science Physical Oncology, Vol:2, Pages:044502-044502

Attwood S, Cortes E, Haining, et al., 2016, Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment, Scientific Reports, Vol:6, ISSN:2045-2322

Chronopoulos A, Robinson B, Sarper M, et al., 2016, ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion, Nature Communications, Vol:7, ISSN:2041-1723, Pages:1-12

Sarper M, Cortes E, Lieberthal T, et al., 2016, ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells, Scientific Reports, Vol:6, ISSN:2045-2322

Robinson BK, Cortes E, Rice AJ, et al., 2016, Quantitative analysis of 3D extracellular matrix remodelling bypancreatic stellate cells, Biology Open, Vol:5, ISSN:2046-6390, Pages:875-882


Ghose R, Rice AJ, Cortes E, et al., 2020, Implementation of a basement membrane invasion assay using mesenteric tissue, CELL-DERIVED MATRICES, PT B, Editor(s): Caballero, Kundu, Reis, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, Pages:99-122


Lachowski D, Cortes E, Robinson B, et al., 2016, SAT-402 - Elucidating the Biomechanical Response of Human Hepatic Stellate Cells on Substrates Mimicking Healthy and Fibrotic Matrix Rigidity, EASL International Liver Congress, Elsevier, Pages:S706-S706, ISSN:0168-8278

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