Overview
1. Coverage of the two back to back EMBO Reports 2019 papers:
Tamoxifen mechanically reprograms the tumourmicroenvironment via HIF-1A and reduces cancer cell survival. https://doi.org/10.15252/embr.201846557
GPER is a mechanoregulator of pancreatic stellate cells and the tumour microenvironment. https://doi.org/10.15252/embr.201846556
Spotlight by Dooling LJ and Discher DE. Inhibiting tumor fibrosis and actomyosin through GPCR activation. Trends in Cancer 2019. https://doi.org/10.1016/j.trecan.2019.02.005
News and Views by Pein M and Oskarsson T. Tamoxifen calms down the distressed PDAC stroma. EMBO Reports 2019. https://doi.org/10.15252/embr.201847334
Cover January 2019: https://www.embopress.org/toc/14693178/20/1
Media coverage:
- European Research Council - 2019. https://erc.europa.eu/projects-figures/stories/new-weapon-against-pancreatic-cancer-way
- Imperial College News - United Kingdom 2018 Breast cancer drug could create chink in the armour of pancreatic cancer.https://www.imperial.ac.uk/news/189471/breast-cancer-drug-could-create-chink/
- Technology Networks - 2018. https://www.technologynetworks.com/tn/news/breast-cancer-drug-repurposed-to-help-treat-pancreatic-cancer-313035
- University of Salamanca School of Pharmacy - 2019 (in Spanish).https://www.facebook.com/permalink.php?story_fbid=1977866262329182&id=550588988390257
- Spanish Newspaper - El Pais - 2019 (in Spanish). https://elpais.com/elpais/2018/12/26/ciencia/1545819644_975504.html
2. Coverage of NATURE MATERIALS 2020 paper:
Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. https://doi.org/10.1038/s41563-019-0567-1
News & Views by Guilluy C and Dolega ME. Syndecan-4 forces integrins to cooperate. Nature Materials 2020. https://doi.org/10.1038/s41563-020-0689-5
Summary video. https://www.youtube.com/watch?v=XPVdx7_V-nU
Media coverage:
- Imperial College News - Cell ‘hands’ to unlock doors in health research, drug design, and bioengineering. https://www.imperial.ac.uk/news/194586/cell-hands-unlock-doors-health-research/
- Drug Target Review - Syndecan-4 cell sensory protrusions activate hallmarks of cancer. https://www.drugtargetreview.com/news/54214/syndecan-4-cell-sensory-protrusions-activate-hallmarks-of-cancer/
- Genetic Engineering & Biotechnology News - When Cell Membrane “Hands” Feel Strain, They Pull Levers Loosing Cancer. https://www.genengnews.com/news/when-cell-membrane-hands-feel-strain-they-pull-levers-loosing-cancer/
- Technology Networks - Cell “Hands” Help Unlock Doors in Drug Design and Bioengineering. https://www.technologynetworks.com/tn/news/cell-hands-help-unlock-doors-in-drug-design-and-bioengineering-328961
- ecancer - Cell 'hands' to unlock doors in health research, drug design and bioengineering. https://ecancer.org/en/news/17134-cell-hands-to-unlock-doors-in-health-research-drug-design-and-bioengineering
- News Medical Life Sciences - Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology. https://www.news-medical.net/news/20200106/Discovery-of-cellular-hands-could-have-implications-in-the-fields-of-cell-developmental-biology.aspx
- Science Daily - Cell 'hands' to unlock doors in health research, drug design, and bioengineering. https://www.sciencedaily.com/releases/2020/01/200106121951.htm
- PhysOrg - Cell 'hands' to unlock doors in health research, drug design, and bioengineering. https://phys.org/news/2020-01-cell-doors-health-drug-bioengineering.html
- EurekAlert - Cell 'hands' to unlock doors in health research, drug design, and bioengineering. https://www.eurekalert.org/news-releases/666802
3. Coverage of NATURE COMMUNICATIONS 2016 paper:
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. https://doi.org/10.1038/ncomms12630
Media coverage:
- The Hippocratic Post – United Kingdom 2016. Vitamin A and Pancreatic Cancer. https://www.hippocraticpost.com/cancer/vitamin-pancreatic-cancer/
- Science Daily – United States 2016. Potential role for vitamin A in pancreatic cancer discovered. https://www.sciencedaily.com/releases/2016/09/160907081917.htm
- Medical News Today 2016. Research suggest potential role for vitamin A in pancreatic cancer.https://www.medicalnewstoday.com/mnt/releases/312794#1
- Interview for Medical Research – United States 2016. https://medicalresearch.com/author-interviews/vitamin-a-may-inhibit-pancreatic-cancer-by-preventing-desmoplasia-that-surround-tumor/27788/
- Imperial College News – United Kingdom 2016. Research suggests potential role for vitamin A in pancreatic cancer. https://www.imperial.ac.uk/news/174346/research-suggests-potential-role-vitamin-pancreatic/
- El mundo en papel- 2016. Sección Futuro. Vitamin A and pancreatic cancer. El español que sabe cómo frenar el cáncer (In Spanish). https://www.elmundo.es/papel/futuro/2016/09/20/57e10a0e468aebaa068b4633.html
- Heraldo Newspaper - 2016. Vitamin A may help to fight pancreatic cancer (In Spanish). https://www.heraldo.es/noticias/salud/2016/09/08/la-vitamina-podria-ayudar-luchar-contra-cancer-pancreas-segun-estudio-1048177-2261131.html
- The Interactive Doctor - 2016. Vitamin A and pancreatic cancer (In Spanish). https://elmedicointeractivo.com/vitamina-puede-desempenhar-papel-lucha-cancer-pancreas-20160912154321106044/
- HispanTV - 2016. Vitamin A against pancreatic cancer? (In Spanish). https://www.hispantv.com/noticias/salud/287385/vitamina-a-contra-cancer-pancreas
4. Coverage of PLOS BIOLOGY 2018 paper:
Mechanotransduction in talin through the interaction of the R8 domain with DLC1. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005599
Editor’s picks collection. Secction:Protein trafficking and Cellular Transport. https://collections.plos.org/collection/cell-biology-picks/
Summary video. https://www.youtube.com/watch?v=SAdEJkeQJws
Media coverage:
- Imperial College News - UK 2018. Imperial takes the fight to cancer in 2018. https://www.imperial.ac.uk/news/189633/imperial-takes-fight-cancer-2018/?hootPostID=bb706de135bf4140ba718fe5d00f9ed5
- Imperial College News - UK 2018. Liver cancer cell ‘switch’ found that could improve future therapies https://www.imperial.ac.uk/news/187473/liver-cancer-cell-switch-found-that/
- Medical Press - US 2018. Liver cancer cell 'switch' found that could improve future therapies. https://medicalxpress.com/news/2018-07-liver-cancer-cell-future-therapies.html?src_id=alt
5. Coverage of Hepatology 2018 paper:
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. https://doi.org/10.1002/hep.30193
Editorial by Blaner WS. Hepatic stellate cells and retinoids: Toward a much more defined relationship. https://doi.org/10.1002/hep.30293
Summary video. https://www.youtube.com/watch?v=o00B2b0suQc
6. Coverage of Oncogene 2018 paper:
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. https://doi.org/10.1038/s41388-018-0631-3
Summary video. https://www.youtube.com/watch?v=IxEnjZ3GfsA