Imperial College London
Mr Joseph Eliahoo

MrJosephEliahoo

Faculty of Medicine, School of Public Health

Statistical Consultant
 
 
 
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Contact

 

j.eliahoo Website

 
 
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Assistant

 

Mrs Krupa Shukla +44 (0)20 7594 1754

 
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Location

 

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Summary

 

Publications

Citation

BibTex format

@article{Clements:2020:10.1016/j.jhep.2019.09.007,
author = {Clements, O and Eliahoo, J and Kim, JU and Taylor-Robinson, SD and Khan, SA},
doi = {10.1016/j.jhep.2019.09.007},
journal = {Journal of Hepatology},
pages = {95--103},
title = {Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.1016/j.jhep.2019.09.007},
volume = {72},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & AimsCholangiocarcinoma (CCA) carries a poor prognosis, is increasing in incidence and its causes are poorly understood. Although some risk factors are known, they vary globally and collectively account for a minority of cases. The aim of this study was to perform a comprehensive meta-analysis of risk factors for intrahepatic (iCCA) and extrahepatic cholangiocarcinoma (eCCA), from Eastern and Western world studies.MethodsA literature search of case-control studies was performed to identify potential risk factors for iCCA and eCCA. Pooled odds ratios (ORs) with 95% CIs and heterogeneity were calculated. Funnel plots were used to assess publication bias, and meta-regression was used to select risk factors for comparison between Eastern and Western studies.ResultsA total of 13 risk factors were selected from 25 case-control studies in 7 geographically diverse countries. The strongest risk factors for both iCCA and eCCA were biliary cysts and stones, cirrhosis, hepatitis B and hepatitis C. Choledochal cysts conferred the greatest risk of both iCCA and eCCA with pooled ORs of 26.71 (95% CI 15.80–45.16) and 34.94 (24.36–50.12), respectively. No significant associations were found between hypertension and obesity for either iCCA or eCCA. Comparing Eastern and Western populations, there was a difference for the association of hepatitis B with iCCA (coefficient=−0.15195; 95% CI −0.278 to −0.025; p=0.022).ConclusionThis is the most comprehensive meta-analysis of CCA risk factors to date. Some risk factors, such as diabetes, although less strong, are increasing globally and may be contributing to rising rates of this cancer.
AU  - Clements,O
AU  - Eliahoo,J
AU  - Kim,JU
AU  - Taylor-Robinson,SD
AU  - Khan,SA
DO  - 10.1016/j.jhep.2019.09.007
EP  - 103
PY  - 2020///
SN  - 0168-8278
SP  - 95
TI  - Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis
T2  - Journal of Hepatology
UR  - http://dx.doi.org/10.1016/j.jhep.2019.09.007
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000503041200013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0168827819305434?via%3Dihub
UR  - http://hdl.handle.net/10044/1/84684
VL  - 72
ER  -
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