Publications
85 results found
Hull JH, Walsted ES, Feary J, et al., 2019, Continuous laryngoscopy during provocation in the assessment of inducible laryngeal obstruction, Laryngoscope, Vol: 129, Pages: 1863-1866, ISSN: 0023-852X
Brittain HK, Feary J, Rosenthal M, et al., 2019, Biallelic human <i>ITCH</i> variants causing a multisystem disease with dysmorphic features: A second report, AMERICAN JOURNAL OF MEDICAL GENETICS PART A, Vol: 179, Pages: 1346-1350, ISSN: 1552-4825
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- Citations: 9
Feary JR, Schofield SJ, Canizales J, et al., 2019, Laboratory animal allergy is preventable in modern research facilities, European Respiratory Journal, Vol: 53, ISSN: 0903-1936
BACKGROUND: Historical data suggest 15% of laboratory animal workers develop IgE sensitisation and 10% symptoms of laboratory animal allergy (LAA), including occupational asthma. Individually ventilated cages (IVC) are replacing conventional open cages; we sought to evaluate their impact on the development of LAA. METHODS: We surveyed 750 laboratory animal workers and measured airborne Mus m 1 (mouse allergen) levels in seven UK institutions. We compared the prevalence of sensitisation to mouse proteins (by specific IgE assay or skin prick test) and of work-related allergic symptoms in IVC-only and open cage units. MEASUREMENTS AND MAIN RESULTS: Full shift Mus m 1 levels were lower in IVC than open cage units (geometric mean 1.00 ng·m-3 (95% confidence interval: 0.73-1.36) versus8.35 ng·m-3 (6.97-9.95); p<0.001) but varied eight-fold across the IVC units (GM range: 0.33-4.12 ng·m-3). Primary analyses on data from 216 participants with <3 years' exposure to mice revealed a lower prevalence of sensitisation in those working in IVC compared with conventional cage units (2.4% (n=2) versus9.8% (n=13); p=0.052). Sensitisation in IVC units varied from 0% to 12.5%; the use of fitted respiratory protection was less common in IVC units where prevalence of sensitisation was higher. Work-related allergy symptoms were more frequently reported by mouse sensitised individuals (46.7% versus 10.9%, p<0.001); and only by those working in open cage units. CONCLUSION: In contemporary practice, LAA is now largely preventable with the use of IVC systems and the judicious use of appropriate respiratory protection.
Vera-Berrios RN, Feary J, Cullinan P, 2019, Basophil activation testing in occupational respiratory allergy to low molecular weight compounds, Current Opinion in Allergy and Clinical Immunology, Vol: 19, Pages: 92-97, ISSN: 1473-6322
Purpose of review There is an unmet need for better immunological tests in cases of suspected occupational asthma to many workplace chemicals; here we consider the basophil activation test (BAT), a potential alternative to the detection of specific IgE antibodies.Recent findings BAT is fairly widely used in general allergy services; and there is increasing experience of its use in the diagnosis of occupational allergy to low molecular weight agents and chemicals including wood dusts, persulphates, antibiotics and latex.Summary There is potential for BAT to become a useful tool in the clinical consideration of occupational asthma and of its mechanisms, and even to take a place in a Bayesian-based diagnostic algorithm. Further development will only occur if specialist centres with appropriate facilities, and preferably in collaboration, contemplate its use.
Bloom C, Saglani S, Feary J, et al., 2019, Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population based cohort 2006 to 2016, European Respiratory Journal, Vol: 53, Pages: 1-8, ISSN: 0903-1936
BACKGROUND:Asthma is the most common respiratory disorder in the UK, yet we have incomplete knowledge on the prevalence of current disease, treatment and exacerbations.METHODS:We used UK electronic healthcare records, 2006 to 2016, to estimate the prevalence of current asthma by year, gender and age (<5, 5-11, 12-17, 18-24, 25-54 and ≥55 years), and the proportion prescribed inhaled corticosteroids (ICS) and additional asthma-therapy, treated for exacerbations and other asthma care markers. RESULTS:Overall current asthma prevalence was 6.5% in 2016 (7.2% in 2006). Prevalence fell in those under 45 years. The lowest prevalence and largest absolute decrease was in children under 5-years. In 2016, 80% of current asthma patients were managed on ICS, (65% in 2006); this increase occurred in all ages, primarily due to an increase in low-dose ICS. During this time there was an increase in all age-groups in the proportion prescribed additional asthma-therapy, treated for an exacerbation within primary care, given an annual asthma review or management plan. Hospitalised exacerbations showed minimal change over time.CONCLUSION:Asthma remains highly prevalent and a significant healthcare burden. In those with a diagnosis, there was an increase in ICS prescriptions and treatment of exacerbations across all age-groups. This may reflect a trend towards more aggressive asthma management within primary care. An apparent decline in prevalence was observed in those aged under 45 years, particularly in children under 5 years.
Canizales J, Feary J, Cullinan P, et al., 2019, Investigating discordance between diagnostic tests for laboratory animal allergy, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB193-AB193, ISSN: 0091-6749
Feary J, Cullinan P, 2019, Occupational diseases, RESPIRATORY MEDICINE, 3RD EDITION, Editors: Palange, Rohde, Publisher: EUROPEAN RESPIRATORY SOCIETY, Pages: 748-752, ISBN: 978-1-84984-079-8
Bloom CI, Palmer T, Feary J, et al., 2018, Exacerbation patterns in adults with asthma in England: A population based study, American Journal of Respiratory and Critical Care Medicine, Vol: 199, Pages: 446-453, ISSN: 1073-449X
Rationale Asthma is heterogeneous and knowledge on exacerbation patterns is lacking. Previous studies have had a relatively short follow-up or focused on severe disease. Objectives Describe exacerbation patterns over a prolonged follow-up in a population including patients of all disease severity. Methods We used electronic healthcare records to identify asthma patients aged 18-55 years and their exacerbations, 2007-2015. A cohort with ≥7-years of data was used to describe exacerbation patterns by asthma severity defined by medication use. Effect estimates for risk factors were calculated for sporadic (single year of exacerbations) and recurrent (>1 year) exacerbation patterns, using logistic regression. In a nested case-control design, the association between a history of exacerbations, spanning 5-years, and a future exacerbation was examined. Measurements and Main Results 51,462 patients were eligible for the 7-year cohort; 64% had no exacerbations. Of those who exacerbated, 51% did so only once; exacerbation frequency increased with disease severity. Only 370 patients (0.7%) were characterised by a frequent-exacerbator phenotype (yearly exacerbations), of whom 58% had mild/moderate asthma. Exacerbation risk factors were not uniquely associated with a particular exacerbation pattern. A past exacerbation increased the risk of a future exacerbation more than all other factors, although this effect dissipated over 5-years. Conclusions During 7-years of follow-up, exacerbations occur in around one-third of patients. Of those who exacerbate, half do not do so again; the timing of future exacerbations is largely unpredictable. Just 2% exhibit a frequent-exacerbator phenotype. Past exacerbation patterns are the most informative risk factor for predicting future exacerbations.
Feary J, Potts J, Schofield S, et al., 2018, AEROALLERGEN EXPOSURE ALONE IS NOT RESPONSIBLE FOR SENSITISATION OF WORKERS TO LABORATORY ANIMAL ALLERGENS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A179-A179, ISSN: 0040-6376
Bloom CI, Feary J, Jarvis D, et al., 2018, CHANGING PREVALENCE OF CURRENT ASTHMA AND INHALED CORTICOSTEROID TREATMENT IN THE UK: POPULATION BASED COHORT 2006 TO 2016, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A63-A64, ISSN: 0040-6376
Feary J, Fitzgerald B, Schofield S, et al., 2018, Evidence based Code of Best Practice for animal research facilities: results of the SPIRAL study, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
De Matteis S, Feary J, Macfarlane J, et al., 2018, Update of the British Occupational Health Research Foundation (BOHRF) guidelines on occupational asthma., 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
Feary J, Canizales J, Fitzgerald C, et al., 2018, Is 'take-out' allergen detectable in laboratory animal facilities?, 28th International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Canizales J, Welch J, Fitzgerald B, et al., 2018, Investigating discordance between diagnostic tests for laboratory animal allergy, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY, Pages: 94-94, ISSN: 0105-4538
De Matteis S, Feary J, Macfarlane J, et al., 2017, UPDATE OF THE BRITISH OCCUPATIONAL HEALTH FOUNDATION (BOHRF) EVIDENCE-BASED GUIDELINES ON THE PREVENTION AND MANAGEMENT OF OCCUPATIONAL ASTHMA, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A205-A205, ISSN: 0040-6376
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- Citations: 1
Selby J, Cullinan P, Feary J, et al., 2017, FEASIBILITY OF CONTINUOUS LARYNGOSCOPY DURING PROVOCATION IN THE ASSESSMENT OF INDUCIBLE LARYNGEAL OBSTRUCTION, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A143-A143, ISSN: 0040-6376
Feary J, Cannon J, Schofield S, et al., 2017, FOLLOW UP OF PATIENTS DIAGNOSED WITH OCCUPATIONAL ASTHMA OR RHINITIS AT ROYAL BROMPTON HOSPITAL, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A204-A205, ISSN: 0040-6376
Feary J, Canizales J, Schofield S, et al., 2017, Sensitisation to mouse allergens in contemporary laboratory animal practice, European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Feary J, Canizales J, Jones M, et al., 2017, Laboratory animal workers' exposure to mouse allergen in animal research facilities, European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Mortimer K, Feary J, 2017, Occupational exposure to pesticides: time to nip it in the bud?, THORAX, Vol: 72, Pages: 489-490, ISSN: 0040-6376
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- Citations: 1
Feary J, Canizales J, Schofield S, et al., 2017, Laboratory Animal Workers' Exposure To Mouse Allergen In Animal Research Facilities, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Feary J, Schofield S, Fitzgerald B, et al., 2017, Laboratory Animal Allergy In The Contemporary World, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Feary J, Fitzgerald B, Szram J, et al., 2016, INDUCIBLE LARYNGEAL OBSTRUCTION MASQUERADING AS WORK-RELATED ASTHMA; A NEW APPROACH, THORAX, Vol: 71, Pages: A71-A71, ISSN: 0040-6376
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- Citations: 1
Feary J, Canizales J, Fitzgerald C, et al., 2016, WORK-RELATED SYMPTOMS IN LABORATORY ANIMAL WORKERS, THORAX, Vol: 71, Pages: A69-A70, ISSN: 0040-6376
Solano E, Fitzgerald B, Cannon J, et al., 2016, LATE ASTHMATIC RESPONSE TO EPOXY RESINS: A CASE REPORT, THORAX, Vol: 71, Pages: A259-A260, ISSN: 0040-6376
Cookson WOC, 2016, Genetics and gene-environment interactions, Parkes' Occupational Lung Disorders, Fourth Edition, Pages: 137-144, ISBN: 9781498715805
Canizales J, Jones M, Semple S, et al., 2016, Mus m 1 personal exposure in laboratory animal workers in facilities where mice are housed in open cages and individually ventilated cages, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Feary J, Fitzgerald B, Schofield S, et al., 2016, Sensitisation to mouse allergens in contemporary laboratory animal workers: The SPIRAL study, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Canizales J, Jones M, Semple S, et al., 2016, Mus m 1 personal exposures in laboratory animal workers in facilities where mice are housed in open or individually ventilated cages, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 214-214, ISSN: 0105-4538
Feary J, Fitzgerald B, Banya W, et al., 2016, Cross-sectional survey of sensitisation to mouse allergens in contemporary laboratory animal workers: the SPIRAL study, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 15-15, ISSN: 0105-4538
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