Publications
85 results found
Feary J, Pinnock H, Cullinan P, 2016, Occupational asthma, British Medical Journal, Vol: 353, ISSN: 1468-5833
Feary J, Cullinan P, 2016, Laboratory animal allergy: a new world, Current Opinion in Allergy and Clinical Immunology, Vol: 16, Pages: 107-112, ISSN: 1528-4050
Purpose of review: In recent years there has been a dramatic shift in the world of animal research whereby genetically modified mice have largely supplanted rats, and individually ventilated cages have been introduced to house delicate experimental animals in place of traditional open cages. Although laboratory animal allergy remains an important cause of occupational asthma, the risks associated with contemporary practice and consequently the opportunities for primary and secondary prevention are largely unknown.Recent findings: Although there is clear confirmation of a widespread increase in animal experiments using mice, the evidence-base on the associated risks has lagged. Individually ventilated cages reduce ambient levels of mouse urinary protein in air but task-based exposures are unquantified. Immunological techniques to identify sensitization to mouse proteins are poorly standardized. The available evidence suggests that modern practices are, in most cases, associated with a reduced incidence of animal sensitization.Summary: There is a paucity of data to inform evidence-based practice in methods to control the incidence of laboratory animal allergy under the prevailing research environment; a better understanding of the relationship between exposures and outcome is urgently needed. As exposures decline, the relative importance of individual susceptibility will become prominent.
Feary JR, Szram J, 2016, Occupational hypersensitivity pneumonitis: what is the evidence, when to think of it, and what to do, Clinical Pulmonary Medicine, Vol: 23, Pages: 23-29, ISSN: 1536-5956
Hypersensitivity pneumonitis (HP), or extrinsic allergic alveolitis, is a relatively rare condition with a variable natural history (acute, subacute, or chronic) and fairly nonspecific features. Patients present with pulmonary symptoms with or without constitutional disturbance. HP can be caused by >300 different agents, which broadly comprise microbial agents (bacteria, fungus), animal antigens, and chemicals, and exposure to these agents may occur in occupational settings-the focus of this article-or elsewhere. HP, particularly due to occupational exposures, is underdiagnosed due to a lack of awareness of the condition and difficulties in identifying and confirming the diagnosis. Bird fancier's lung and farmer's lung have historically been the most common causes of HP. More recently, metalworking fluids used in engineering have emerged as an increasingly common etiological agent for occupational HP and several outbreaks have been reported. Making a diagnosis of occupational HP is crucial both for the individual, so as to remove them from exposure and maximize the chance of a full recovery, and for the employer, so that they can identify other cases and put into place strategies to prevent further cases. There is no single gold standard test used to confirm HP, and a combination of a careful occupational exposure history, clinical history, radiology, and immunology findings can help ascertain a diagnosis. Certain key questions can be useful in eliciting a work-related pattern to symptoms.
Feary JR, Fitzgerald B, Lightfoot Z, et al., 2015, CROSS-SECTIONAL STUDY OF PREVALENCE OF SENSITISATION TO MOUSE ALLERGENS IN LABORATORY ANIMAL WORKERS: THE SPIRAL (SAFE PRACTICE IN REDUCING ALLERGY IN LABORATORIES) STUDY, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A104-A105, ISSN: 0040-6376
Canizales J, Jones M, Semple S, et al., 2015, TO DETERMINE MUS M 1 PERSONAL EXPOSURE IN LABORATORY ANIMAL WORKERS IN FACILITIES WHERE MICE ARE HOUSED IN OPEN CAGES AND INDIVIDUALLY VENTILATED CAGES, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A106-A106, ISSN: 0040-6376
Campbell H, Canizales J, Semple S, et al., 2015, CARRY OUT OF ANIMAL ALLERGENS FROM ANIMAL FACILITY ON SKIN OF LABORATORY ANIMAL WORKERS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A105-A106, ISSN: 0040-6376
Canizales J, Welch J, Fitzgerald B, et al., 2015, DETERMINATION OF SPECIFIC IGE ANTIBODIES TO MOUSE PROTEINS IN LABORATORY ANIMAL WORKERS, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A102-A103, ISSN: 0040-6376
Feary J, Welch J, Lightfoot Z, et al., 2015, Comparison of immunology tests for determining sensitisation to mouse proteins in laboratory animal workers, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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Feary J, Cannon J, Welch J, et al., 2015, Investigation and diagnosis of occupational asthma to nematodes, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Jones M, Semple S, Schofield S, et al., 2015, The potential of a low-cost particle counter to quantify airborne particulate matter in a laboratory animal facility, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Canizales J, Jones M, Semple S, et al., 2015, Determining Mus m 1 personal exposure in laboratory animal workers where mice are housed in individually ventilated cages, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Feary J, Cannon J, Tarzi M, et al., 2015, Occupational asthma from a horticultural nematode, Steinernema feltiae, Lancet Respiratory Medicine, Vol: 3, Pages: E28-E29, ISSN: 2213-2619
Jones M, Semple S, Schofield S, et al., 2015, The Potential of a Low-Cost Particle Counter to Quantify Airborne Particulate Matter in a Laboratory Animal Facility, Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Publisher: MOSBY-ELSEVIER, Pages: AB76-AB76, ISSN: 0091-6749
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- Citations: 1
Feary JR, Lightfoot Z, Fitzgerald B, et al., 2014, THE ROLE OF INDIVIDUALLY VENTILATED CAGES IN PREVENTION OF LABORATORY ANIMAL ALLERGY: A PROOF OF CONCEPT STUDY, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A6-A6, ISSN: 0040-6376
Finney LJ, Feary JR, Leonardi-Bee J, et al., 2013, Chronic obstructive pulmonary disease in sub-Saharan Africa: a systematic review, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 17, Pages: 583-589, ISSN: 1027-3719
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- Citations: 46
Feary J, Britton J, Leonardi-Bee J, 2011, Atopy and current intestinal parasite infection: a systematic review and meta-analysis, ALLERGY, Vol: 66, Pages: 569-578, ISSN: 0105-4538
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- Citations: 92
Feary JR, Rodrigues LC, Smith CJ, et al., 2010, Prevalence of major comorbidities in subjects with COPD and incidence of myocardial infarction and stroke: a comprehensive analysis using data from primary care, THORAX, Vol: 65, Pages: 956-962, ISSN: 0040-6376
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- Citations: 298
Feary JR, Venn AJ, Mortimer K, et al., 2010, Experimental hookworm infection: a randomized placebo-controlled trial in asthma, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 40, Pages: 299-306, ISSN: 0954-7894
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- Citations: 142
Gibson J, Hubbard R, Smith C, et al., 2010, Association Between Involvement in Motor Vehicle Crashes and Disordered Sleep - a UK Population-Based Study, Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Falcone FH, Telford G, Hooi D, et al., 2009, Antigen-driven basophil activation is indicative of early <i>Necator americanus</i> infection in IgE-seronegative patients, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 124, Pages: 1343-1350, ISSN: 0091-6749
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- Citations: 16
Blount D, Hooi D, Feary J, et al., 2009, Immunologic Profiles of Persons Recruited for a Randomized, Placebo-Controlled Clinical Trial of Hookworm Infection, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 81, Pages: 911-916, ISSN: 0002-9637
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- Citations: 46
Feary J, Venn A, Brown A, et al., 2009, Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 39, Pages: 1060-1068, ISSN: 0954-7894
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- Citations: 66
Feary J, Britton J, 2007, Dietary supplements and asthma: another one bites the dust, THORAX, Vol: 62, Pages: 466-468, ISSN: 0040-6376
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- Citations: 13
Mortimer K, Brown A, Feary J, et al., 2006, Dose-ranging study for trials of therapeutic infection with <i>Necator americanus</i> in humans, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 75, Pages: 914-920, ISSN: 0002-9637
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- Citations: 95
Feary JR, Crutchley J, Dowson LJ, 2005, An audit of long term oxygen therapy in Wolverhampton: Implications for the new oxygen guidelines, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II64-II64, ISSN: 0040-6376
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