DR JAMES M. FLANAGAN

Faculty of Medicine, Department of Surgery & Cancer

Reader in Epigenetics

Contact

+44 (0)20 7594 2127j.flanagan

Location

Institute of Reproductive and Developmental BiologyHammersmith Campus

Summary

Dr James Flanagan, completed his PhD in 2002 at the Queensland Institute of Medical Research in Brisbane, Australia, and has pursued postdoctoral work in Cancer Genetics, Epigenetics and Cancer Epigenetics. He was awarded a Breast Cancer Campaign Scientific Fellowship (Imperial, 2009-2014) and Senior Lecturer (2014-2019) and is now Reader in Epigenetics (2019-present) in the Division of Cancer, Dept. of Surgery and Cancer, Faculty of Medicine at Imperial College London.

He was awarded the British Association of Cancer Research Translational Researcher Award in 2011 and the prestigious DataIQ award in 2023 for his work using Shopping Loyalty Cards for early detection of ovarian cancer.

He is the principal investigator (PI) for the OCA funded programme "Risk and Prevention" and PI of the CRUK funded project "Cancer Loyalty Card Study (CLOCS)"

In 2021 he was appointed as the Director of the MRes Cancer Biology

Selected Publications

Journal Articles

Flanagan JM, Wilson A, Koo C, et al.Flanagan JM, Wilson A, Koo C, Masrour N, Gallon J, Loomis E, Flower K, Wilhelm-Benartzi C, Hergovich A, Cunnea P, Gabra H, Braicu EI, Sehouli J, Darb-Esfahani S, Vanderstichele A, Vergote I, Kreuzinger C, Cacsire Castillo-Tong D, Wisman GB, Berns EM, Siddiqui N, Paul J, Brown R close, 2017, Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients, Clinical Cancer Research, Vol:23, ISSN:1557-3265, Pages:2213-2222

van veldhoven K, Polidoro S, Baglietto L, et al.van veldhoven K, Polidoro S, Baglietto L, Severi G, Sacerdote C, Panico S, Mattiello A, Palli D, Masala G, Krogh V, Agnoli C, Tumino R, Frasca G, Flower K, Curry E, Orr N, Tomczyk K, Jones M, Ashworth A, Swerdlow A, Chadeau M, Lund E, Garcia-Closas M, Sandanger T, Flanagan JM, vineis P close, 2015, Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis, Clinical Epigenetics, Vol:7, ISSN:1868-7083

Shenker NS, Polidoro S, van Veldhoven K, et al.Shenker NS, Polidoro S, van Veldhoven K, Sacerdote C, Ricceri F, Birrell MA, Belvisi MG, Brown R, Vineis P, Flanagan JM close, 2013, Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking, Human Molecular Genetics, Vol:22, ISSN:0964-6906, Pages:843-851

Brennan K, Garcia-Closas M, Orr N, et al.Brennan K, Garcia-Closas M, Orr N, Fletcher O, Jones M, Ashworth A, Swerdlow A, Thorne H, Riboli E, Vineis P, Dorronsoro M, Clavel-Chapelon F, Panico S, Onland-Moret NC, Trichopoulos D, Kaaks R, Khaw K-T, Brown R, Flanagan JM close, 2012, Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk, Cancer Research, Vol:72, ISSN:0008-5472, Pages:2304-2313

Flanagan JM, Cocciardi S, Waddell N, et al.Flanagan JM, Cocciardi S, Waddell N, Johnstone CN, Marsh A, Henderson S, Simpson P, da Silva L, Khanna K, Lakhani S, Boshoff C, Chenevix-Trench G close, 2010, DNA Methylome of Familial Breast Cancer Identifies Distinct Profiles Defined by Mutation Status, American Journal of Human Genetics, Vol:86, ISSN:0002-9297, Pages:420-433

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