Imperial College London

DrJeromeFourre

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

j.fourre

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

8 results found

Couch LS, Fiedler J, Chick G, Clayton R, Dries E, Wienecke LM, Fu L, Fourre J, Pandey P, Derda AA, Wang BX, Jabbour R, Shanmuganathan M, Wright P, Lyon AR, Terracciano CM, Thum T, Harding SEet al., 2021, Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure, Cardiovascular Research, ISSN: 0008-6363

AIMS: Takotsubo syndrome (TTS) is an acute heart failure, typically triggered by high adrenaline during physical or emotional stress. It is distinguished from myocardial infarction (MI) by a characteristic pattern of ventricular basal hypercontractility with hypokinesis of apical segments, and absence of coronary occlusion. We aimed to understand whether recently discovered circulating biomarkers miR-16 and miR-26a, which differentiate TTS from MI at presentation, were mechanistically involved in the pathophysiology of TTS. METHODS AND RESULTS: miR-16 and miR-26a were co-overexpressed in rats with AAV and TTS induced with an adrenaline bolus. Untreated isolated rat cardiomyocytes were transfected with pre-/anti-miRs and functionally assessed. Ventricular basal hypercontraction and apical depression were accentuated in miR-transfected animals after induction of TTS. In vitro miR-16 and/or miR-26a overexpression in isolated apical (but not basal) cardiomyocytes produced strong depression of contraction, with loss of adrenaline sensitivity. They also enhanced the initial positive inotropic effect of adrenaline in basal cells. Decreased contractility after TTS-miRs was reproduced in non-failing human apical cardiomyocytes. Bioinformatic profiling of miR targets, followed by expression assays and functional experiments, identified reductions of CACNB1 (L-type calcium channel Cavβ subunit), RGS4 (regulator of G-protein signalling 4) and G-protein subunit Gβ (GNB1) as underlying these effects. CONCLUSION: miR-16 and miR-26a sensitise the heart to TTS-like changes produced by adrenaline. Since these miRs have been associated with anxiety and depression, they could provide a mechanism whereby priming of the heart by previous stress causes an increased likelihood of TTS in the future. TRANSLATIONAL PERSPECTIVE: TTS-associated miRs have the potential to be active players predisposing to TTS. Feasibly, their measurement in recovered TTS patients during subsequent peri

Journal article

King O, Cruz-Moreira D, Kit-Anan W, Sayed A, Wang BX, Fourre J, Randi AM, Rasponi M, Terracciano CMet al., 2020, Influence of perfusable microvasculature on excitation-contraction coupling in IPSC-derived myocardium, Publisher: OXFORD UNIV PRESS, Pages: 3590-3590, ISSN: 0195-668X

Conference paper

King O, Cruz-Moreira D, Kermani F, Wang B, Kit-Anan SW, Fourre J, Randi AM, Rasponi M, Terracciano CMet al., 2020, NON-MYOCYTE INFLUENCE ON EXCITATION-CONTRACTION COUPLING IN INDUCED PLURIPOTENT STEM CELL DERIVED MYOCARDIUM, Publisher: SPRINGER, Pages: 272-272, ISSN: 0920-3206

Conference paper

King O, Cruz-Moreira D, Kit-Anan SW, Sayed A, Wang B, Fourre J, Randi AM, Rasponi M, Terracciano CMet al., 2020, Vascularized Myocardium-On-A-Chip: Excitation-Contraction Coupling in Perfused Cardiac Co-Cultures, 64th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 410A-410A, ISSN: 0006-3495

Conference paper

Fourre JD, Bardi I, King O, Pericleous C, Maughan R, Mason J, Terracciano Cet al., 2019, Endothelial cell activation by pro-inflammatory cytokines exerts novel paracrine effects on cocultured cardiomyocytes, Publisher: WILEY, Pages: 91-91, ISSN: 1748-1708

Conference paper

Fourre J, Bardi I, Maughan RT, Terracciano CM, Mason JCet al., 2019, Endothelial cell activation by pro-inflammatory cytokines exerts novel paracrine effects on co-cultured cardiomyocytes, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 3904-3904, ISSN: 0195-668X

Conference paper

King O, Kermani F, Wang B, Kit-Anan W, Fourre J, Randi AM, Terracciano CMet al., 2019, Endothelial Cell Regulation of Excitation-Contraction Coupling in Induced Pluripotent Stem Cell Derived Myocardium, 63rd Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 153A-153A, ISSN: 0006-3495

Conference paper

Fourre J, Terracciano C, Mason J, 2019, Endothelial Cells Exert Stimulus-Specific Paracrine Effects on Co-Cultured Cardiomyocytes During Inflammation, 3rd Joint Meeting of the European-Society-for-Microcirculation (ESM) and the European-Vascular-Biology-Organization (EVBO), Publisher: KARGER, Pages: 35-35, ISSN: 1018-1172

Conference paper

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