Publications
250 results found
Wright KM, Friedland JS, 2002, Differential regulation of chemokine secretion in tuberculous and staphylococcal osteomyelitis, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 17, Pages: 1680-1690, ISSN: 0884-0431
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- Citations: 25
THOMAS LH, 2002, Steroids Fail to Down-Regulate Respiratory Syncytial Virus-Induced IL-8 Secretion in Infants, Pediatric Research, Vol: 52, Pages: 368-372, ISSN: 0031-3998
Ameixa C, Friedland JS, 2002, Interleukin-8 secretion from <i>Mycobacterium tuberculosis</i>-infected monocytes is regulated by protein tyrosine kinases but not by ERK1/2 or p38 mitogen-activated protein kinases, INFECTION AND IMMUNITY, Vol: 70, Pages: 4743-4746, ISSN: 0019-9567
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- Citations: 37
Klein JL, Nair SK, Harrison TG, et al., 2002, Prosthetic valve endocarditis caused by <i>Bartonella quintana</i>, EMERGING INFECTIOUS DISEASES, Vol: 8, Pages: 202-203, ISSN: 1080-6040
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- Citations: 17
Friedland JS, Shaw TC, Price NM, et al., 2002, Differential regulation of MMP-1/9 and TIMP-1 secretion in human monocytic cells in response to <i>Mycobacterium tuberculosis</i>, MATRIX BIOLOGY, Vol: 21, Pages: 103-110, ISSN: 0945-053X
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- Citations: 36
Moore DAJ, Lightstone L, Javid B, et al., 2002, High rates of tuberculosis in end-stage renal failure: The impact of international migration, EMERGING INFECTIOUS DISEASES, Vol: 8, Pages: 77-78, ISSN: 1080-6040
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- Citations: 45
Friedland JS, Constantin D, Shaw TC, et al., 2001, Regulation of interleukin-8 gene expression after phagocytosis of zymosan by human monocytic cells, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 70, Pages: 447-454, ISSN: 0741-5400
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- Citations: 25
Hargreaves S, Holmes A, Friedland JS, 2001, Europe's health-care lottery, LANCET, Vol: 357, Pages: 1434-1435, ISSN: 0140-6736
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- Citations: 2
Ameixa C, Friedland JS, 2001, Down-regulation of interleukin-8 secretion from <i>Mycobacterium tuberculosis</i>-infected monocytes by interleukin-4 and-10 but not by interleukin-13, INFECTION AND IMMUNITY, Vol: 69, Pages: 2470-2476, ISSN: 0019-9567
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- Citations: 35
Price NM, Farrar J, Chau TTH, et al., 2001, Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo, JOURNAL OF IMMUNOLOGY, Vol: 166, Pages: 4223-4230, ISSN: 0022-1767
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- Citations: 93
Thomas LH, Wickremasinghe MIY, Sharland M, et al., 2000, Synergistic upregulation of interleukin-8 secretion from pulmonary epithelial cells by direct and monocyte-dependent effects of respiratory syncytial virus infection, JOURNAL OF VIROLOGY, Vol: 74, Pages: 8425-8433, ISSN: 0022-538X
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- Citations: 27
Handforth J, Friedland JS, Sharland M, 2000, Basic epidemiology and immunopathology of RSV in children., Paediatr Respir Rev, Vol: 1, Pages: 210-214, ISSN: 1526-0542
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in infants and young children. Around 20 000 RSV-infected infants require hospitalization in the UK during each yearly epidemic, which is about 3% of the birth cohort. Most children are infected by 2 years of age. Risk factors for severe disease include young infants, prematurity, chronic lung and cardiac conditions or immunodeficiency. Humoral immunity is incomplete and short-lived, yet reinfections cause less severe disease. RSV infects infants despite the presence of specific neutralizing antibodies. RSV infection can be linked to the development of individual wheezing episodes. A competent cellular immune system is necessary to reduce disease severity. RSV infection provokes an RSV-specific T-lymphocyte response with the release of cytokines. There is a delicate balance between the protective and disease-enhancing effects of the host's immune response to RSV infection.
Hargreaves S, Holmes A, Friedland JS, 2000, Refugees, asylum seekers, and general practice: room for improvement?, BRITISH JOURNAL OF GENERAL PRACTICE, Vol: 50, Pages: 531-532, ISSN: 0960-1643
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- Citations: 12
Shaw TC, Thomas LH, Friedland JS, 2000, Regulation of IL-10 secretion after phagocytosis of <i>mycobacterium tuberculosis</i> by human monocytic cells, CYTOKINE, Vol: 12, Pages: 483-486, ISSN: 1043-4666
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- Citations: 38
Fullilove S, Jellis J, Hughes SPF, et al., 2000, Local and systemic concentrations of tumour necrosis factor-α, interleukin-6 and interleukin-8 in bacterial osteomyelitis, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 94, Pages: 221-224, ISSN: 0035-9203
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- Citations: 17
Remick DG, Newcomb DE, Friedland JS, 2000, Whole-blood assays for cytokine production., Methods Mol Med, Vol: 36, Pages: 101-112, ISSN: 1543-1894
Substantial interest has been generated by the potential roles of the cytokines in health and disease (1). This has prompted considerable investigation into how these mediators are regulated to answer such basic questions as which stimuli initiate transcription and what factors are responsible for inhibiting secretion. This has resulted in elegant studies that have begun to define the intracellular-signaling pathways responsible for the upregulation of cytokines (2,3). Many of these studies have been done with cultures of cell lines derived from cancers or primary cultures of isolated fibroblasts, endothelial cells, or isolated mononuclear cells. Whereas these studies have provided substantial insight, they may be limited in their scope because they do not include all cell-cell or cell-protein interactions that take place in vivo. Other studies have used endotoxin injection into normal human volunteers to study the upregulation of cytokines (4,5). These studies with the normal volunteers provide precise information about the kinetics of cytokine production, but they are difficult to perform and very expensive. The whole-blood model serves as a useful bridge between using normal volunteers and isolated peripheral blood mononuclear cells. For critically ill patients it would be impossible to perform endotoxin infusion studies, and it would even be difficult to conduct these types of studies in chronically ill patients. Whole blood may also be used to study the immune responses of such patients in an attempt to determine how their cytokine regulation differs from normal individuals.
Wickremasinghe MI, Thomas LH, Friedland JS, 1999, Pulmonary epithelial cells are a source of IL-8 in the response to <i>Mycobacterium tuberculosis</i>:: Essential role of IL-1 from infected monocytes in a NF-κB-dependent network, JOURNAL OF IMMUNOLOGY, Vol: 163, Pages: 3936-3947, ISSN: 0022-1767
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- Citations: 132
Hargreaves S, Holmes A, Friedland JS, 1999, Health-care provision for asylum seekers and refugees in the UK, LANCET, Vol: 353, Pages: 1497-1498, ISSN: 0140-6736
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- Citations: 14
Thomas LH, Sharland M, Friedland JS, 1999, Dexamethasone does not downregulate interleukin-8 or RANTES secretion induced by respiratory syncytial virus in infants., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A243-A243, ISSN: 1073-449X
Wickremasinghe MI, Thomas LH, Friedland JS, 1999, Monocyte-derived IL1 has a pivotal role in control of IL8 and RANTES secretion from respiratory epithelial cells in human pulmonary tuberculosis., JOURNAL OF LEUKOCYTE BIOLOGY, Pages: 22-22, ISSN: 0741-5400
Friedland JS, Evans C, Fullilove S, et al., 1998, Proinflammatory cytokines in osteomyelitis, EUROPEAN CYTOKINE NETWORK, Vol: 9, Pages: 427-427, ISSN: 1148-5493
Evans CAW, Garcia HH, Hartnell A, et al., 1998, Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis, INFECTION AND IMMUNITY, Vol: 66, Pages: 4522-4525, ISSN: 0019-9567
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- Citations: 41
Thomas LH, Friedland JS, Sharland M, et al., 1998, Respiratory syncytial virus-induced RANTES production from human bronchial epithelial cells is dependent on nuclear factor-κB nuclear binding and is inhibited by adenovirus-mediated expression of inhibitor of κBα, JOURNAL OF IMMUNOLOGY, Vol: 161, Pages: 1007-1016, ISSN: 0022-1767
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- Citations: 115
Evans CAW, Jellis J, Hughes SPF, et al., 1998, Tumor necrosis factor-α, interleukin-6, and interleukin-8 secretion and the acute-phase response in patients with bacterial and tuberculous osteomyelitis, JOURNAL OF INFECTIOUS DISEASES, Vol: 177, Pages: 1582-1587, ISSN: 0022-1899
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- Citations: 47
Friedland JS, 1998, Cytokines in infectious diseases, JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, Vol: 32, Pages: 195-198, ISSN: 0035-8819
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- Citations: 4
Cooke FJ, Friedland JS, 1998, Spontaneous breast abscess due to <i>Mycobacterium fortuitum</i>, CLINICAL INFECTIOUS DISEASES, Vol: 26, Pages: 760-761, ISSN: 1058-4838
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- Citations: 14
Elizaga J, Friedland JS, 1997, Monitoring compliance with antituberculous treatment by detection of isoniazid in urine, LANCET, Vol: 350, Pages: 1225-1226, ISSN: 0140-6736
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- Citations: 23
Evans C, Garcia HH, Gilman RH, et al., 1997, Controversies in the management of cysticercosis, Emerging Infectious Diseases, Vol: 3, Pages: 403-405, ISSN: 1080-6059
Friedland JS, Porter JC, Daryanani S, et al., 1996, Plasma proinflammatory cytokine concentrations, acute physiology and chronic health evaluation (APACHE) III scores and survival in patients in an intensive care unit, CRITICAL CARE MEDICINE, Vol: 24, Pages: 1775-1781, ISSN: 0090-3493
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- Citations: 107
Porter JC, Bennett ED, Friedland JS, 1996, Further echoes of the Spanish Lady, LANCET, Vol: 348, Pages: 694-694, ISSN: 0140-6736
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- Citations: 1
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