Publications
250 results found
Tadokera R, Meintjes GA, Wilkinson KA, et al., 2014, Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 44, Pages: 127-136, ISSN: 0014-2980
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- Citations: 42
Singh S, Saraiva L, Elkington PTG, et al., 2014, Regulation of matrix metalloproteinase-1,-3, and-9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin- sensitive PI3K/p70<SUP>S6K</SUP> cascade, FASEB JOURNAL, Vol: 28, Pages: 85-93, ISSN: 0892-6638
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- Citations: 19
Belton M, Brilha S, Fryer T, et al., 2013, SEVERE HYPOXIA EXISTS WITHIN PULMONARY TUBERCULOSIS LESIONS AND AUGMENTS MATRIX METALLOPROTEINASE-MEDIATED IMMUNOPATHOLOGY, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A2-A2, ISSN: 0040-6376
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- Citations: 1
Seddon J, Kasprowicz V, Walker NF, et al., 2013, Procollagen III N-terminal Propeptide and Desmosine are Released by Matrix Destruction in Pulmonary Tuberculosis, JOURNAL OF INFECTIOUS DISEASES, Vol: 208, Pages: 1571-1579, ISSN: 0022-1899
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- Citations: 31
Eisen S, Pealing L, Aldridge RW, et al., 2013, Effects of Ascent to High Altitude on Human Antimycobacterial Immunity, PLOS One, Vol: 8, ISSN: 1932-6203
Background: Tuberculosis infection, disease and mortality are all less common at high than low altitude and ascentto high altitude was historically recommended for treatment. The immunological and mycobacterial mechanismsunderlying the association between altitude and tuberculosis are unclear. We studied the effects of altitude onmycobacteria and antimycobacterial immunity.Methods: Antimycobacterial immunity was assayed in 15 healthy adults residing at low altitude before and after theyascended to 3400 meters; and in 47 long-term high-altitude residents. Antimycobacterial immunity was assessed asthe extent to which participants’ whole blood supported or restricted growth of genetically modified luminescentBacille Calmette-Guérin (BCG) mycobacteria during 96 hours incubation. We developed a simplified whole bloodassay that could be used by a technician in a low-technology setting. We used this to compare mycobacterial growthin participants’ whole blood versus positive-control culture broth and versus negative-control plasma.Results: Measurements of mycobacterial luminescence predicted the number of mycobacterial colonies cultured sixweeks later. At low altitude, mycobacteria grew in blood at similar rates to positive-control culture broth whereasascent to high altitude was associated with restriction (p≤0.002) of mycobacterial growth to be 4-times less than inculture broth. At low altitude, mycobacteria grew in blood 25-times more than negative-control plasma whereasascent to high altitude was associated with restriction (p≤0.01) of mycobacterial growth to be only 6-times more thanin plasma. There was no evidence of differences in antimycobacterial immunity at high altitude between people whohad recently ascended to high altitude versus long-term high-altitude residents.Conclusions: An assay of luminescent mycobacterial growth in whole blood was adapted and found to be feasible inlow-resource settings. This demonstrated that ascent to or resi
Green JA, Rand L, Moores R, et al., 2013, In an <i>in vitro</i> model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and-3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway, JOURNAL OF NEUROINFLAMMATION, Vol: 10
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- Citations: 5
Patrick Fitzwater S, Andrew Sechler G, Jave O, et al., 2013, Second-line anti-tuberculosis drug concentrations for susceptibility testing in the MODS assay, EUROPEAN RESPIRATORY JOURNAL, Vol: 41, Pages: 1163-1171, ISSN: 0903-1936
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- Citations: 18
Ugarte-Gil CA, Elkington P, Gilman RH, et al., 2013, Induced Sputum MMP-1,-3 &-8 Concentrations during Treatment of Tuberculosis, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 75
Chang SW, Pan WS, Lozano Beltran D, et al., 2013, Gut Hormones, Appetite Suppression and Cachexia in Patients with Pulmonary TB, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 169
Sandhu G, Battaglia F, Ely BK, et al., 2012, Discriminating Active from Latent Tuberculosis in Patients Presenting to Community Clinics, PLOS One, Vol: 7, ISSN: 1932-6203
Background: Because of the high global prevalence of latent TB infection (LTBI), a key challenge in endemic settings isdistinguishing patients with active TB from patients with overlapping clinical symptoms without active TB but with coexistingLTBI. Current methods are insufficiently accurate. Plasma proteomic fingerprinting can resolve this difficulty byproviding a molecular snapshot defining disease state that can be used to develop point-of-care diagnostics.Methods: Plasma and clinical data were obtained prospectively from patients attending community TB clinics in Peru andfrom household contacts. Plasma was subjected to high-throughput proteomic profiling by mass spectrometry. Statisticalpattern recognition methods were used to define mass spectral patterns that distinguished patients with active TB fromsymptomatic controls with or without LTBI.Results: 156 patients with active TB and 110 symptomatic controls (patients with respiratory symptoms without active TB)were investigated. Active TB patients were distinguishable from undifferentiated symptomatic controls with accuracy of87% (sensitivity 84%, specificity 90%), from symptomatic controls with LTBI (accuracy of 87%, sensitivity 89%, specificity82%) and from symptomatic controls without LTBI (accuracy 90%, sensitivity 90%, specificity 92%).Conclusions: We show that active TB can be distinguished accurately from LTBI in symptomatic clinic attenders usinga plasma proteomic fingerprint. Translation of biomarkers derived from this study into a robust and affordable point-of-careformat will have significant implications for recognition and control of active TB in high prevalence settings.
Walker NF, Clark SO, Oni T, et al., 2012, Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 185, Pages: 989-997, ISSN: 1073-449X
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- Citations: 103
Elkington PT, Ugarte-Gil CA, Friedland JS, 2011, Matrix metalloproteinases in tuberculosis, EUROPEAN RESPIRATORY JOURNAL, Vol: 38, Pages: 456-464, ISSN: 0903-1936
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- Citations: 85
Friedland JS, 2011, Tuberculosis in the 21st century, CLINICAL MEDICINE, Vol: 11, Pages: 353-357, ISSN: 1470-2118
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- Citations: 5
Green JA, Dholakia S, Janczar K, et al., 2011, <i>Mycobacterium</i> <i>tuberculosis</i>-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways, JOURNAL OF NEUROINFLAMMATION, Vol: 8
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- Citations: 27
Elkington P, Shiomi T, Breen R, et al., 2011, MMP-1 drives immunopathology in human tuberculosis and transgenic mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 121, Pages: 1827-1833, ISSN: 0021-9738
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- Citations: 171
Elkington PT, D'Armiento JM, Friedland JS, 2011, Tuberculosis Immunopathology: The Neglected Role of Extracellular Matrix Destruction, SCIENCE TRANSLATIONAL MEDICINE, Vol: 3, ISSN: 1946-6234
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- Citations: 64
Green JA, Chau TTH, Farrar JJ, et al., 2011, CNS INFECTION, CSF MATRIX METALLOPROTEINASE CONCENTRATIONS, AND CLINICAL/LABORATORY FEATURES, NEUROLOGY, Vol: 76, Pages: 577-579, ISSN: 0028-3878
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- Citations: 11
Kubler A, Singh S, Gardiner H, et al., 2010, Immunomodulation by anti-mycobacterial drugs used to treat tuberculosis, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 104-105, ISSN: 0019-2805
Uddin J, Gonzalez AE, Gilman RH, et al., 2010, Mechanisms Regulating Monocyte CXCL8 Secretion in Neurocysticercosis and the Effect of Antiparasitic Therapy, JOURNAL OF IMMUNOLOGY, Vol: 185, Pages: 4478-4484, ISSN: 0022-1767
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- Citations: 9
O'Kane CM, Elkington PT, Jones MD, et al., 2010, STAT3, p38 MAPK, and NF-κB Drive Unopposed Monocyte-Dependent Fibroblast MMP-1 Secretion in Tuberculosis, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 43, Pages: 465-474, ISSN: 1044-1549
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- Citations: 52
Fitzwater SP, Caviedes L, Gilman RH, et al., 2010, Prolonged Infectiousness of Tuberculosis Patients in a Directly Observed Therapy Short-Course Program with Standardized Therapy, CLINICAL INFECTIOUS DISEASES, Vol: 51, Pages: 371-378, ISSN: 1058-4838
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- Citations: 50
Green JA, Elkington PT, Pennington CJ, et al., 2010, <i>Mycobacterium tuberculosis</i> Upregulates Microglial Matrix Metalloproteinase-1 and-3 Expression and Secretion via NF-κB- and Activator Protein-1-Dependent Monocyte Networks, JOURNAL OF IMMUNOLOGY, Vol: 184, Pages: 6492-6503, ISSN: 0022-1767
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- Citations: 58
Reddy KP, Brady MF, Gilman RH, et al., 2010, Microscopic Observation Drug Susceptibility Assay for Tuberculosis Screening before Isoniazid Preventive Therapy in HIV-Infected Persons, CLINICAL INFECTIOUS DISEASES, Vol: 50, Pages: 988-996, ISSN: 1058-4838
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- Citations: 19
Green JA, Tran CTH, Farrar JJ, et al., 2009, Dexamethasone, Cerebrospinal Fluid Matrix Metalloproteinase Concentrations and Clinical Outcomes in Tuberculous Meningitis, PLOS ONE, Vol: 4, ISSN: 1932-6203
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- Citations: 53
Friedland JS, 2009, Are you taking the lead?, CLINICAL MEDICINE, Vol: 9, Pages: 305-306, ISSN: 1470-2118
Rand L, Green JA, Saraiva L, et al., 2009, Matrix Metalloproteinase-1 Is Regulated in Tuberculosis by a p38 MAPK-Dependent, <i>p</i>-Aminosalicylic Acid-Sensitive Signaling Cascade, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 5865-5872, ISSN: 0022-1767
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- Citations: 38
Handforth J, Friedland JS, Sharland M, 2009, Inhaled corticosteroids after respiratory syncytial virus infection, BMJ-BRITISH MEDICAL JOURNAL, Vol: 338, ISSN: 1756-1833
Escombe AR, Moore DAJ, Gilman RH, et al., 2009, Upper-Room Ultraviolet Light and Negative Air Ionization to Prevent Tuberculosis Transmission, PLOS Medicine, Vol: 6, ISSN: 1549-1277
BackgroundInstitutional tuberculosis (TB) transmission is an important public health problem highlightedby the HIV/AIDS pandemic and the emergence of multidrug- and extensively drug-resistant TB.Effective TB infection control measures are urgently needed. We evaluated the efficacy of upperroomultraviolet (UV) lights and negative air ionization for preventing airborne TB transmissionusing a guinea pig air-sampling model to measure the TB infectiousness of ward air.Methods and FindingsFor 535 consecutive days, exhaust air from an HIV-TB ward in Lima, Peru´, was passed throughthree guinea pig air-sampling enclosures each housing approximately 150 guinea pigs, using a2-d cycle. On UV-off days, ward air passed in parallel through a control animal enclosure and asimilar enclosure containing negative ionizers. On UV-on days, UV lights and mixing fans wereturned on in the ward, and a third animal enclosure alone received ward air. TB infection inguinea pigs was defined by monthly tuberculin skin tests. All guinea pigs underwent autopsyto test for TB disease, defined by characteristic autopsy changes or by the culture ofMycobacterium tuberculosis from organs. 35% (106/304) of guinea pigs in the control groupdeveloped TB infection, and this was reduced to 14% (43/303) by ionizers, and to 9.5% (29/307)by UV lights (both p , 0.0001 compared with the control group). TB disease was confirmed in8.6% (26/304) of control group animals, and this was reduced to 4.3% (13/303) by ionizers, andto 3.6% (11/307) by UV lights (both p , 0.03 compared with the control group). Time-to-eventanalysis demonstrated that TB infection was prevented by ionizers (log-rank 27; p , 0.0001)and by UV lights (log-rank 46; p , 0.0001). Time-to-event analysis also demonstrated that TBdisease was prevented by ionizers (log-rank 3.7; p ¼ 0.055) and by UV lights (log-rank 5.4; p ¼0.02). An alternative analysis using an airborne infection model demonstrated that ionizersprevented 60% of TB in
Hargreaves S, Carballo M, Friedland JS, 2009, Screening migrants for tuberculosis: where next?, LANCET INFECTIOUS DISEASES, Vol: 9, Pages: 139-140, ISSN: 1473-3099
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- Citations: 20
Sheen P, O'Kane CM, Chaudhary K, et al., 2009, High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation, EUROPEAN RESPIRATORY JOURNAL, Vol: 33, Pages: 134-141, ISSN: 0903-1936
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- Citations: 53
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