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@article{Lopez:2018:10.4269/ajtmh.17-0425,
author = {Lopez, J and Loader, M and Smith, D and Pastorius, D and Bravard, M and Caviedes, L and Romero, K and Clark, T and Checkley, W and Ticona, E and Friedland, JS and Gilman, R},
doi = {10.4269/ajtmh.17-0425},
journal = {American Journal of Tropical Medicine and Hygiene},
pages = {1637--1639},
title = {Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis},
url = {http://dx.doi.org/10.4269/ajtmh.17-0425},
volume = {98},
year = {2018}
}

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TY  - JOUR
AB  - To reduce transmission of tuberculosis (TB) in resource-limited countries where TB remains a major cause of mortality, novel diagnostic tools are urgently needed. We evaluated the fractional concentration of exhaled nitric oxide (FeNO) as an easily measured, non-invasive potential biomarker for diagnosis and monitoring of treatment response in participants with pulmonary TB including multi-drug resistant (MDR)-TB in Lima, Peru. In a longitudinal study however, we found no differences in baseline median FeNO levels between 38 TB participants and 93 age-matched controls (13 parts per billion (ppb) (IQR 8-26), vs. 15 ppb (IQR 12-24)), and there was no change over 60 days of treatment (15 ppb (IQR 10-19) at day 60). Taking this and previous evidence together we conclude FeNO is not of value in either the diagnosis of pulmonary TB nor as a marker of treatment response.
AU  - Lopez,J
AU  - Loader,M
AU  - Smith,D
AU  - Pastorius,D
AU  - Bravard,M
AU  - Caviedes,L
AU  - Romero,K
AU  - Clark,T
AU  - Checkley,W
AU  - Ticona,E
AU  - Friedland,JS
AU  - Gilman,R
DO  - 10.4269/ajtmh.17-0425
EP  - 1639
PY  - 2018///
SN  - 0002-9637
SP  - 1637
TI  - Exhaled nitric oxide is not a biomarker for pulmonary tuberculosis
T2  - American Journal of Tropical Medicine and Hygiene
UR  - http://dx.doi.org/10.4269/ajtmh.17-0425
UR  - http://hdl.handle.net/10044/1/59246
VL  - 98
ER  -

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