Imperial College London
Alternate

ProfessorJillGilmour

Faculty of Medicine, Department of Infectious Disease

Honorary Principal Research Fellow 
 
 
 
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Contact

 

+44 (0)20 3315 5098j.gilmour

 
 
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Location

 

J.2.3 Immunology DepartmentChelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dalel:2021:10.1097/QAD.0000000000002864,
author = {Dalel, J and Ung, SK and Hayes, P and Black, SL and Joseph, S and King, DF and Makinde, J and Gilmour, J},
doi = {10.1097/QAD.0000000000002864},
journal = {AIDS},
pages = {1167--1177},
title = {HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8(+) T cells},
url = {http://dx.doi.org/10.1097/QAD.0000000000002864},
volume = {35},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives: Interleukin-21 (IL-21) has been linked with the generation of virus-specific memory CD8+ T cells following acute infection with HIV-1 and reduced exhaustion of CD8+ T cells. IL-21 has also been implicated in the promotion of CD8+ T-cell effector functions during viral infection. Little is known about the expression of interleukin-21 receptor (IL-21R) during HIV-1 infection or its role in HIV-1-specific CD8+ T-cell maintenance and subsequent viral control.Methods: We compared levels of IL-21R expression on total and memory subsets of CD8+ T cells from HIV-1-negative and HIV-1-positive donors. We also measured IL-21R on antigen-specific CD8+ T cells in volunteers who were positive for HIV-1 and had cytomegalovirus-responding T cells. Finally, we quantified plasma IL-21 in treatment-naive HIV-1-positive individuals and compared this with IL-21R expression.Results: IL-21R expression was significantly higher on CD8+ T cells (P = 0.0256), and on central memory (P = 0.0055) and effector memory (P = 0.0487) CD8+ T-cell subsets from HIV-1-positive individuals relative to HIV-1-negative individuals. For those infected with HIV-1, the levels of IL-21R expression on HIV-1-specific CD8+ T cells correlated significantly with visit viral load (r = 0.6667, P = 0.0152, n = 13) and inversely correlated with plasma IL-21 (r = −0.6273, P = 0.0440, n = 11). Lastly, CD8+ T cells from individuals with lower set point viral load who demonstrated better viral control had the lowest levels of IL-21R expression and highest levels of plasma IL-21.Conclusion: Our data demonstrates significant associations between IL-21R expression on peripheral CD8+ T cells and viral load, as well as disease trajectory. This suggests that the IL-21 receptor could be a novel marker of CD8+ T-cell dysfunction during HIV-1 infection.
AU  - Dalel,J
AU  - Ung,SK
AU  - Hayes,P
AU  - Black,SL
AU  - Joseph,S
AU  - King,DF
AU  - Makinde,J
AU  - Gilmour,J
DO  - 10.1097/QAD.0000000000002864
EP  - 1177
PY  - 2021///
SN  - 0269-9370
SP  - 1167
TI  - HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8(+) T cells
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000002864
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680439800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.lww.com/aidsonline/Fulltext/2021/07010/HIV_1_infection_and_the_lack_of_viral_control_are.2.aspx
UR  - http://hdl.handle.net/10044/1/94357
VL  - 35
ER  -
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