Summary
Julia Gorelik is Professor of Cellular Biophysics, within the Cardiovascular Science Division at the National Heart and Lung Institute, Imperial College London.
She is working in the interface between biophysics and cardiovascular Research. She obtained her Ph.D. in Cell Biology from St-Petersburg's Institute of Cytology, Russian Academy of Science in 1996. She spent 7 years working with Professor Yuri Korchev (Imperial College, Hammersmith Campus) who was the first to develop a new high resolution microscopic technique that is suitable for studying living cells - Scanning Ion Conductance Microscopy (SICM).
Dr Gorelik has a long-standing interest in the heart, which led her to develop the SICM to measure contraction, rhythm and calcium dynamics of cardiomyocytes simultaneously, allowing the study arrhythmias and heart failure conditions on cultured heart cells. She built a SICM microscope at Brompton Campus and combined it with fluorescence resonance energy transfer (FRET) technique for study spatial distribution of beta-adrenoreceptors on the surface of the cardiomyocytes. Dr Gorelik is a scientist with an extensive network of collaborators.
Finally, in 2010, Dr Gorelik was awarded an Imperial College Research Excellence Award to study 'New Nanoscale Technique to Study cAMP/cGMP Localisation in Cardiovascular Tissue'.
Publications
Journals
Judina A, Niglas M, Leonov V, et al., 2023, Pulmonary Hypertension-Associated Right Ventricular Cardiomyocyte Remodelling Reduces Treprostinil Function., Cells, Vol:12
Koch C, Reilly-O’Donnell B, Gutierrez R, et al., 2023, Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers, Nature Nanotechnology, Vol:18, ISSN:1748-3387, Pages:1483-1491
Kwan Z, Paulose Nadappuram B, Leung MM, et al., 2023, Microtubule-mediated regulation of β2AR translation and function in failing hearts, Circulation Research, Vol:133, ISSN:0009-7330, Pages:944-958
Song Q, Alvarez-Laviada A, Schrup SE, et al., 2023, Opto-SICM framework combines optogenetics with scanning ion conductance microscopy for probing cell-to-cell contacts, Commucations Biology, Vol:6, ISSN:2399-3642
Medvedev RY, Turner DGP, DeGuire FC, et al., 2023, Caveolae-associated cAMP/Ca2+-mediated mechano-chemical signal transduction in mouse atrial myocytes., J Mol Cell Cardiol, Vol:184, Pages:75-87