Julia Gorelik is Professor of Cellular Biophysics, within the Cardiovascular Science Division at the National Heart and Lung Institute, Imperial College London.
She is working in the interface between biophysics and cardiovascular Research. She obtained her Ph.D. in Cell Biology from St-Petersburg's Institute of Cytology, Russian Academy of Science in 1996. She spent 7 years working with Professor Yuri Korchev (Imperial College, Hammersmith Campus) who was the first to develop a new high resolution microscopic technique that is suitable for studying living cells - Scanning Ion Conductance Microscopy (SICM).
Dr Gorelik has a long-standing interest in the heart, which led her to develop the SICM to measure contraction, rhythm and calcium dynamics of cardiomyocytes simultaneously, allowing the study arrhythmias and heart failure conditions on cultured heart cells. She built a SICM microscope at Brompton Campus and combined it with fluorescence resonance energy transfer (FRET) technique for study spatial distribution of beta-adrenoreceptors on the surface of the cardiomyocytes. Dr Gorelik is a scientist with an extensive network of collaborators.
Finally, in 2010, Dr Gorelik was awarded an Imperial College Research Excellence Award to study 'New Nanoscale Technique to Study cAMP/cGMP Localisation in Cardiovascular Tissue'.
et al., 2021, Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations., J Hepatol, Vol:74, Pages:1087-1096
et al., 2021, CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β2AR in isogenic hPSC-derived cardiomyocytes, Molecular Therapy - Methods and Clinical Development, Vol:20, ISSN:2329-0501, Pages:39-53
et al., 2021, Local hyperactivation of L-type Ca2+ channels increases spontaneous Ca2+ release activity and cellular hypertrophy in right ventricular myocytes from heart failure rats, Scientific Reports, Vol:11, ISSN:2045-2322
et al., 2021, Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension., Hypertension, Vol:77, Pages:605-616
et al., 2021, Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics., Circ Res, Vol:128, Pages:92-114