Publications
205 results found
Gorelik J, Shevchuk A, de Swiet M, et al., 2004, Comparison of the arrhythmogenic effects of tauro- and glycoconjugates of cholic acid in an <i>in vitro</i> study of rat cardiomyocytes, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 111, Pages: 867-870, ISSN: 1470-0328
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- Citations: 56
Gorelik J, Zhang YJ, Shevchuk AI, et al., 2004, The use of scanning ion conductance microscopy to image A6 cells, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 217, Pages: 101-108, ISSN: 0303-7207
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- Citations: 62
Darszon A, Wood CD, Beltrán C, et al., 2004, Measuring lon fluxes in sperm, DEVELOPMENT OF SEA URCHINS, ASCIDIANS, AND OTHER INVERTEBRATE DEUTEROSTOMES: EXPERIMENTAL APPROACHES, Vol: 74, Pages: 545-+, ISSN: 0091-679X
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- Citations: 10
Gorelik J, Vodyanoy I, Shevchuk AI, et al., 2003, Esmolol is antiarrhythmic in doxorubicin-induced arrhythmia in cultured cardiomyocytes - determination by novel rapid cardiomyocyte assay, FEBS LETTERS, Vol: 548, Pages: 74-78, ISSN: 1873-3468
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- Citations: 17
Gorelik J, Shevchuk AI, Frolenkov GI, et al., 2003, Dynamic assembly of surface structures in living cells, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 5819-5822, ISSN: 0027-8424
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- Citations: 132
Gorelik J, Shevchuk AI, Diakonov I, et al., 2003, Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an <i>in vitro</i> study of rat cardiomyocytes, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 110, Pages: 467-474, ISSN: 1470-0328
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- Citations: 31
Gorelik J, 2003, Dexamethasone and ursodeoxycholic acid protect against the arrhythmogenic effect of taurocholate in an in vitro study of rat cardiomyocytes, BJOG: An International Journal of Obstetrics and Gynaecology, Vol: 110, Pages: 467-474, ISSN: 1470-0328
Rothery AM, Gorelik J, Bruckbauer A, et al., 2003, A novel light source for SICM-SNOM of living cells, JOURNAL OF MICROSCOPY-OXFORD, Vol: 209, Pages: 94-101, ISSN: 0022-2720
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- Citations: 25
Gorelik J, Shevchuk A, Ramalho M, et al., 2002, Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: Application to single virus-like particle entry into a cell, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 99, Pages: 16018-16023, ISSN: 0027-8424
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- Citations: 84
Gorelik J, Gu YC, Spohr HA, et al., 2002, Ion channels in small cells and subcellular structures can be studied with a smart patch-clamp system, BIOPHYSICAL JOURNAL, Vol: 83, Pages: 3296-3303, ISSN: 0006-3495
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- Citations: 92
Gorelik J, Harding SE, Shevchuk AI, et al., 2002, Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics, CLINICAL SCIENCE, Vol: 103, Pages: 191-200, ISSN: 0143-5221
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- Citations: 74
Gu YC, Gorelik J, Spohr HA, et al., 2002, High-resolution scanning patch-clamp: new insights into cell function, FASEB JOURNAL, Vol: 16, Pages: 748-+, ISSN: 0892-6638
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- Citations: 65
Gu YC, Spohr HA, Gorelik J, et al., 2002, High-resolution functional mapping of cardiac myocyte ion channels, BIOPHYSICAL JOURNAL, Vol: 82, Pages: 596A-596A, ISSN: 0006-3495
Rothery AM, Bruckbauer A, Ying LM, et al., 2002, A novel light source for SNOM of living cells, BIOPHYSICAL JOURNAL, Vol: 82, Pages: 497A-497A, ISSN: 0006-3495
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- Citations: 2
Gorelik J, Gu YC, Spohr HA, et al., 2002, High-resolution scanning patch-clamp technique, BIOPHYSICAL JOURNAL, Vol: 82, Pages: 266A-266A, ISSN: 0006-3495
Shevchuk AI, Gorelik J, Harding SE, et al., 2001, Simultaneous measurement of Ca<SUP>2+</SUP> and cellular dynamics:: Combined scanning ion conductance and optical microscopy to study contracting cardiac myocytes, BIOPHYSICAL JOURNAL, Vol: 81, Pages: 1759-1764, ISSN: 0006-3495
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- Citations: 139
WILLIAMSON C, GORELIK J, EATON BM, et al., 2001, The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis, Clinical Science, Vol: 100, Pages: 363-369, ISSN: 0143-5221
<jats:p>Obstetric cholestasis is a liver disease of pregnancy that can be complicated by sudden, hitherto unexplained, intra-uterine fetal death. Because intra-uterine death occurs suddenly, and because fetal heart rate abnormalities have been reported in obstetric cholestasis, we hypothesized that intra-uterine death is caused by impaired fetal cardiomyocyte function, resulting in fetal cardiac arrest. Obstetric cholestasis is associated with raised levels of maternal and fetal serum bile acids, and we propose that these may alter cardiomyocyte function. It was not possible to investigate the effects of bile acids on the intact human fetal heart at a cellular level. Therefore we used the closest available model of fetal myocardium at term: a primary culture of neonatal rat cardiomyocytes in which cells beat synchronously and develop pacemaker activity. The effect of the primary bile acid taurocholate (0.3 mM and 3 mM) on cultures of single cardiomyocytes, each with its own independent rate of contraction, was a reversible decrease in the rate of contraction and in the proportion of beating cells (P < 0.001). Addition of taurocholate to a network of synchronously beating cells caused a similar decrease in the rate of contraction. Furthermore, the integrity of the network was destroyed, and cells ceased to beat synchronously. Taurocholate also resulted in altered calcium dynamics and loss of synchronous beating. These data suggest that raised levels of the bile acid taurocholate in the fetal serum in obstetric cholestasis may result in the development of a fetal dysrhythmia and in sudden intra-uterine death.</jats:p>
Williamson C, Gorelik J, Eaton BM, et al., 2001, The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intra-uterine fetal death in obstetric cholestasis, CLINICAL SCIENCE, Vol: 100, Pages: 363-369, ISSN: 0143-5221
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- Citations: 136
Negulyaev Y, Gorelik J, Shevchuk A, et al., 2001, Functional and optical imaging of living cells by local application via a micropipette., BIOPHYSICAL JOURNAL, Vol: 80, Pages: 164A-164A, ISSN: 0006-3495
Shevchuk A, Gorelik J, Gu Y, et al., 2001, Simultaneous measurement of fluorescence and membrane dynamics in cardiac myocytes: Combined scanning ion conductance and laser confocal microscopy, BIOPHYSICAL JOURNAL, Vol: 80, Pages: 163A-164A, ISSN: 0006-3495
Gorelik JV, Cherepanova OA, Voronkina IV, et al., 2001, Laminin-2/4 from human placenta is a better adhesion agent for primary keratinocytes than laminin-1 from EHS sarcoma, CELL BIOLOGY INTERNATIONAL, Vol: 25, Pages: 395-402, ISSN: 1065-6995
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- Citations: 8
Korchev YE, Raval M, Lab MJ, et al., 2000, Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells, BIOPHYSICAL JOURNAL, Vol: 78, Pages: 2675-2679, ISSN: 0006-3495
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- Citations: 71
Korchev YE, Gorelik J, Lab MJ, et al., 2000, Cell volume measurement using scanning ion conductance microscopy, BIOPHYSICAL JOURNAL, Vol: 78, Pages: 451-457, ISSN: 0006-3495
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- Citations: 130
Gorelik JV, Paramonov BA, Blinova MI, et al., 2000, Matrigel increases the rate of split wound healing and promotes keratinocyte 'take' in deep wounds in rats, CYTOTECHNOLOGY, Vol: 32, Pages: 79-86, ISSN: 0920-9069
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- Citations: 5
GORELIK JV, BLINOVA MI, DIAKONOV IA, et al., 1995, ROLE OF FEEDER CELLS IN SPREADING AND CYTOSKELETON ORGANIZATION OF NEWBORN RAT KERATINOCYTES, CELL BIOLOGY INTERNATIONAL, Vol: 19, Pages: 59-64, ISSN: 1065-6995
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- Citations: 2
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