Imperial College London
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Prof Jason P. Hallett

Faculty of Engineering, Department of Chemical Engineering

Professor of Sustainable Chemical Technology
 
 
 
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Contact

 

+44 (0)20 7594 5388j.hallett Website

 
 
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Location

 

228bBone BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Shmool:2022:10.1039/d2py00053a,
author = {Shmool, TA and Constantinou, A and Jirkas, A and Zhao, C and Georgiou, TK and Hallett, J},
doi = {10.1039/d2py00053a},
journal = {Polymer Chemistry},
pages = {2340--2350},
title = {Next generation strategy for tuning the thermoresponsive properties of micellar and hydrogel drug delivery vehicles using ionic liquids},
url = {http://dx.doi.org/10.1039/d2py00053a},
volume = {13},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Amongst the greatest challenges in developing injectable controlled thermoresponsive micellar and hydrogel drug delivery vehicles include tuning the cloud point (CP) and reducing the gelation temperature (Tgel), below 37 °C, without compromising stability and solubility. Here, a unique strategy is employed using ionic liquid (IL) matrices to produce stable micellar and hydrogel delivery vehicles of distinct thermoresponsive properties. Each formulation includes the in-house synthesised polymer OEGMA30020-b-BuMA22-b-DEGMA11 with FITC-IgG. Both micellar-IL and hydrogel-IL formulations exhibit enhanced stability following 120 days of storage under 4 °C compared to in phosphate buffered saline (PBS). Visual tests demonstrate that the CP of the micellar-IL carriers can be finely tuned (31- 46 °C). Rheology measurements show that hydrogel strength is significantly increased and Tgel is reduced, from 40 °C in PBS to 30 °C with IL. Finally, a unique stabilisation mechanism is proposed, triggered by the synergetic action of the excipients and IL in each system
AU  - Shmool,TA
AU  - Constantinou,A
AU  - Jirkas,A
AU  - Zhao,C
AU  - Georgiou,TK
AU  - Hallett,J
DO  - 10.1039/d2py00053a
EP  - 2350
PY  - 2022///
SN  - 1759-9954
SP  - 2340
TI  - Next generation strategy for tuning the thermoresponsive properties of micellar and hydrogel drug delivery vehicles using ionic liquids
T2  - Polymer Chemistry
UR  - http://dx.doi.org/10.1039/d2py00053a
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2022/PY/D2PY00053A
UR  - http://hdl.handle.net/10044/1/96086
VL  - 13
ER  -
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