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@article{Varricchi:2016:10.1111/all.12878,
author = {Varricchi, G and Harker, J and Borriello, F and Marone, G and Durham, SR and Shamji, MH},
doi = {10.1111/all.12878},
journal = {Allergy},
pages = {1086--1094},
title = {T follicular helper (Tfh ) cells in normal immune responses and in allergic disorders.},
url = {http://dx.doi.org/10.1111/all.12878},
volume = {71},
year = {2016}
}

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TY  - JOUR
AB  - Follicular helper T cells (Tfh ) are located within germinal centers of lymph nodes. Cognate interaction between Tfh , B cells, and IL-21 drives B cells to proliferate and differentiate into plasma cells thereby leading to antibody production. Tfh cells and IL-21 are involved in infectious and autoimmune diseases, immunodeficiencies, vaccination, and cancer. Human peripheral blood CXCR5(+) CD4(+) T cells comprise different subsets of Tfh -like cells. Despite the importance of the IgE response in the pathogenesis of allergic disorders, little is known about the role of follicular and blood Tfh cells and IL-21 in human and experimental allergic disease. Here, we review recent advances regarding the phenotypic and functional characteristics of both follicular and blood Tfh cells and of the IL-21/IL-21R system in the context of allergic disorders.
AU  - Varricchi,G
AU  - Harker,J
AU  - Borriello,F
AU  - Marone,G
AU  - Durham,SR
AU  - Shamji,MH
DO  - 10.1111/all.12878
EP  - 1094
PY  - 2016///
SN  - 0105-4538
SP  - 1086
TI  - T follicular helper (Tfh ) cells in normal immune responses and in allergic disorders.
T2  - Allergy
UR  - http://dx.doi.org/10.1111/all.12878
VL  - 71
ER  -

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DR JAMES A HARKER

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