Imperial College London
Alternate

DR JAMES A HARKER

Faculty of Medicine, National Heart & Lung Institute

Senior Lecturer in Respiratory Science
 
 
 
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Contact

 

+44 (0)20 7594 3171j.harker

 
 
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Location

 

360Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Greczmiel:2017:10.1126/sciimmunol.aam8686,
author = {Greczmiel, U and Kräutler, NJ and Pedrioli, A and Bartsch, I and Agnellini, P and Bedenikovic, G and Harker, J and Richter, K and Oxenius, A},
doi = {10.1126/sciimmunol.aam8686},
journal = {Science Immunology},
title = {Sustained T follicular helper cell response is essential for control of chronic viral infection.},
url = {http://dx.doi.org/10.1126/sciimmunol.aam8686},
volume = {2},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - During chronic viral infections, both CD8 and CD4 T cell responses are functionally compromised. Alongside exhaustion of CD8 T cells during chronic viral infections, it has also been documented that the CD4 T cells have an increased propensity to differentiate toward CXCR5+ T follicular helper cell (TFH) lineage. Whether these TFH cells contribute to the immune response to chronic viral infection has remained unclear. Using chronic lymphocytic choriomeningitis virus (LCMV) infection in conjunction with an in vivo system where TFH cells can be conditionally ablated, we have established that these TFH cells do in fact play an important protective function. Specifically, we demonstrate that these TFH cells are essential for the late emergence of neutralizing LCMV-specific antibodies that keep viral titers in check and ultimately allow mice to clear the virus. By supporting the generation of neutralizing antibodies, we show that sustained activity of TFH cells promotes control of the chronic infection in face of exhausted CD8 T cell responses.
AU  - Greczmiel,U
AU  - Kräutler,NJ
AU  - Pedrioli,A
AU  - Bartsch,I
AU  - Agnellini,P
AU  - Bedenikovic,G
AU  - Harker,J
AU  - Richter,K
AU  - Oxenius,A
DO  - 10.1126/sciimmunol.aam8686
PY  - 2017///
SN  - 2470-9468
TI  - Sustained T follicular helper cell response is essential for control of chronic viral infection.
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.aam8686
UR  - http://hdl.handle.net/10044/1/55413
VL  - 2
ER  -
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