Imperial College London
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DrJethroHerberg

Faculty of Medicine, Department of Infectious Disease

Clinical Reader in Paediatric Infectious Disease
 
 
 
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j.herberg

 
 
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Location

 

231Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whittaker:2020:10.1001/jama.2020.10369,
author = {Whittaker, E and Bamford, A and Kenny, J and Kaforou, M and Jones, CE and Shah, P and Ramnarayan, P and Fraisse, A and Miller, O and Davies, P and Kucera, F and Brierley, J and McDougall, M and Carter, M and Tremoulet, A and Shimizu, C and Herberg, J and Burns, JC and Lyall, H and Levin, M},
doi = {10.1001/jama.2020.10369},
journal = {JAMA},
pages = {259--269},
title = {Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2},
url = {http://dx.doi.org/10.1001/jama.2020.10369},
volume = {324},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance  In communities with high rates of coronavirus disease 2019, reports have emerged of children with an unusual syndrome of fever and inflammation.Objectives  To describe the clinical and laboratory characteristics of hospitalized children who met criteria for the pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS) and compare these characteristics with other pediatric inflammatory disorders.Design, Setting, and Participants  Case series of 58 children from 8 hospitals in England admitted between March 23 and May 16, 2020, with persistent fever and laboratory evidence of inflammation meeting published definitions for PIMS-TS. The final date of follow-up was May 22, 2020. Clinical and laboratory characteristics were abstracted by medical record review, and were compared with clinical characteristics of patients with Kawasaki disease (KD) (n = 1132), KD shock syndrome (n = 45), and toxic shock syndrome (n = 37) who had been admitted to hospitals in Europe and the US from 2002 to 2019.Exposures  Signs and symptoms and laboratory and imaging findings of children who met definitional criteria for PIMS-TS from the UK, the US, and World Health Organization.Main Outcomes and Measures  Clinical, laboratory, and imaging characteristics of children meeting definitional criteria for PIMS-TS, and comparison with the characteristics of other pediatric inflammatory disorders.Results  Fifty-eight children (median age, 9 years [interquartile range {IQR}, 5.7-14]; 33 girls [57%]) were identified who met the criteria for PIMS-TS. Results from SARS-CoV-2 polymerase chain reaction tests were positive in 15 of 58 patients (26%) and SARS-CoV-2 IgG test results were positive in 40 of 46 (87%). In total, 45 of 58 patients (78%) had evidence of current or prior SARS-CoV-2 infection. All children presented with fever and nonspecific symptoms, including v
AU  - Whittaker,E
AU  - Bamford,A
AU  - Kenny,J
AU  - Kaforou,M
AU  - Jones,CE
AU  - Shah,P
AU  - Ramnarayan,P
AU  - Fraisse,A
AU  - Miller,O
AU  - Davies,P
AU  - Kucera,F
AU  - Brierley,J
AU  - McDougall,M
AU  - Carter,M
AU  - Tremoulet,A
AU  - Shimizu,C
AU  - Herberg,J
AU  - Burns,JC
AU  - Lyall,H
AU  - Levin,M
DO  - 10.1001/jama.2020.10369
EP  - 269
PY  - 2020///
SN  - 0098-7484
SP  - 259
TI  - Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2
T2  - JAMA
UR  - http://dx.doi.org/10.1001/jama.2020.10369
UR  - https://jamanetwork.com/journals/jama/fullarticle/2767209
VL  - 324
ER  -
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