Imperial College London
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DrJethroHerberg

Faculty of Medicine, Department of Infectious Disease

Clinical Reader in Paediatric Infectious Disease
 
 
 
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j.herberg

 
 
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Location

 

231Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hagedoorn:2020:10.1371/journal.pmed.1003208,
author = {Hagedoorn, N and Borensztajn, D and Nijman, R and Balode, A and von, Both U and Carrol, E and Eleftheriou, I and Emonts, M and Van, Der Flier M and de, Groot R and Herberg, J and Kohlmaier, B and Lim, E and Maconochie, I and Martinon-Torres, F and Nieboer, D and Pokorn, M and Strle, F and Tsolia, M and Yeung, S and Zavadska, D and Zenz, W and Vermont, C and Levin, M and Moll, H},
doi = {10.1371/journal.pmed.1003208},
journal = {PLoS Medicine},
title = {Variation in antibiotic prescription rates in febrile children presenting to Emergency Departments across Europe (MOFICHE): a multicentre observational study},
url = {http://dx.doi.org/10.1371/journal.pmed.1003208},
volume = {17},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe prescription rate of antibiotics is high for febrile children visiting the emergency department (ED), contributing to antimicrobial resistance. Large studies at European EDs covering diversity in antibiotic and broad-spectrum prescriptions in all febrile children are lacking. A better understanding of variability in antibiotic prescriptions in EDs and its relation with viral or bacterial disease is essential for the development and implementation of interventions to optimise antibiotic use. As part of the PERFORM (Personalised Risk assessment in Febrile illness to Optimise Real-life Management across the European Union) project, the MOFICHE (Management and Outcome of Fever in Children in Europe) study aims to investigate variation and appropriateness of antibiotic prescription in febrile children visiting EDs in Europe.Methods and findingsBetween January 2017 and April 2018, data were prospectively collected on febrile children aged 0–18 years presenting to 12 EDs in 8 European countries (Austria, Germany, Greece, Latvia, the Netherlands [n = 3], Spain, Slovenia, United Kingdom [n = 3]). These EDs were based in university hospitals (n = 9) or large teaching hospitals (n = 3). Main outcomes were (1) antibiotic prescription rate; (2) the proportion of antibiotics that were broad-spectrum antibiotics; (3) the proportion of antibiotics of appropriate indication (presumed bacterial), inappropriate indication (presumed viral), or inconclusive indication (unknown bacterial/viral or other); (4) the proportion of oral antibiotics of inappropriate duration; and (5) the proportion of antibiotics that were guideline-concordant in uncomplicated urinary and upper and lower respiratory tract infections (RTIs). We determined variation of antibiotic prescription and broad-spectrum prescription by calculating standardised prescription rates using multilevel logistic regression and adjusted for general characteristics (e.g., age, sex, comorbidity, referral), diseas
AU  - Hagedoorn,N
AU  - Borensztajn,D
AU  - Nijman,R
AU  - Balode,A
AU  - von,Both U
AU  - Carrol,E
AU  - Eleftheriou,I
AU  - Emonts,M
AU  - Van,Der Flier M
AU  - de,Groot R
AU  - Herberg,J
AU  - Kohlmaier,B
AU  - Lim,E
AU  - Maconochie,I
AU  - Martinon-Torres,F
AU  - Nieboer,D
AU  - Pokorn,M
AU  - Strle,F
AU  - Tsolia,M
AU  - Yeung,S
AU  - Zavadska,D
AU  - Zenz,W
AU  - Vermont,C
AU  - Levin,M
AU  - Moll,H
DO  - 10.1371/journal.pmed.1003208
PY  - 2020///
SN  - 1549-1277
TI  - Variation in antibiotic prescription rates in febrile children presenting to Emergency Departments across Europe (MOFICHE): a multicentre observational study
T2  - PLoS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1003208
UR  - http://hdl.handle.net/10044/1/82104
VL  - 17
ER  -
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