Imperial College London
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DrJethroHerberg

Faculty of Medicine, Department of Infectious Disease

Clinical Reader in Paediatric Infectious Disease
 
 
 
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j.herberg

 
 
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Location

 

231Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zandstra:2020:10.3389/fped.2020.00355,
author = {Zandstra, J and van, de Geer A and Tanck, MWT and Dimitriades, DVS-B and Aarts, CEM and Dietz, SM and van, Bruggen R and Schweintzger, NA and Zenz, W and Emonts, M and Zavadska, D and Pokorn, M and Usuf, E and Moll, HA and Schlapbach, LJ and Carrol, ED and Paulus, S and Tsolia, M and Fink, C and Yeung, S and Shimizu, C and Tremoulet, A and Galassini, R and Wright, VJ and Martinon-Torres, F and Herberg, J and Burns, J and Levin, M and Kuijpers, TW},
doi = {10.3389/fped.2020.00355},
journal = {Frontiers in Pediatrics},
title = {Biomarkers for the discrimination of acute kawasaki disease from infections in childhood},
url = {http://dx.doi.org/10.3389/fped.2020.00355},
volume = {8},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Kawasaki disease (KD) is a vasculitis of early childhood mimicking several infectious diseases. Differentiation between KD and infectious diseases is essential as KD's most important complication—the development of coronary artery aneurysms (CAA)—can be largely avoided by timely treatment with intravenous immunoglobulins (IVIG). Currently, KD diagnosis is only based on clinical criteria. The aim of this study was to evaluate whether routine C-reactive protein (CRP) and additional inflammatory parameters myeloid-related protein 8/14 (MRP8/14 or S100A8/9) and human neutrophil-derived elastase (HNE) could distinguish KD from infectious diseases.Methods and Results: The cross-sectional study included KD patients and children with proven infections as well as febrile controls. Patients were recruited between July 2006 and December 2018 in Europe and USA. MRP8/14, CRP, and HNE were assessed for their discriminatory ability by multiple logistic regression analysis with backward selection and receiver operator characteristic (ROC) curves. In the discovery cohort, the combination of MRP8/14+CRP discriminated KD patients (n = 48) from patients with infection (n = 105), with area under the ROC curve (AUC) of 0.88. The HNE values did not improve discrimination. The first validation cohort confirmed the predictive value of MRP8/14+CRP to discriminate acute KD patients (n = 26) from those with infections (n = 150), with an AUC of 0.78. The second validation cohort of acute KD patients (n = 25) and febrile controls (n = 50) showed an AUC of 0.72, which improved to 0.84 when HNE was included.Conclusion: When used in combination, the plasma markers MRP8/14, CRP, and HNE may assist in the discrimination of KD from both proven and suspected infection.
AU  - Zandstra,J
AU  - van,de Geer A
AU  - Tanck,MWT
AU  - Dimitriades,DVS-B
AU  - Aarts,CEM
AU  - Dietz,SM
AU  - van,Bruggen R
AU  - Schweintzger,NA
AU  - Zenz,W
AU  - Emonts,M
AU  - Zavadska,D
AU  - Pokorn,M
AU  - Usuf,E
AU  - Moll,HA
AU  - Schlapbach,LJ
AU  - Carrol,ED
AU  - Paulus,S
AU  - Tsolia,M
AU  - Fink,C
AU  - Yeung,S
AU  - Shimizu,C
AU  - Tremoulet,A
AU  - Galassini,R
AU  - Wright,VJ
AU  - Martinon-Torres,F
AU  - Herberg,J
AU  - Burns,J
AU  - Levin,M
AU  - Kuijpers,TW
DO  - 10.3389/fped.2020.00355
PY  - 2020///
SN  - 2296-2360
TI  - Biomarkers for the discrimination of acute kawasaki disease from infections in childhood
T2  - Frontiers in Pediatrics
UR  - http://dx.doi.org/10.3389/fped.2020.00355
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000560073900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.frontiersin.org/articles/10.3389/fped.2020.00355/full
UR  - http://hdl.handle.net/10044/1/83348
VL  - 8
ER  -
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