Imperial College London
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DrJethroHerberg

Faculty of Medicine, Department of Infectious Disease

Clinical Reader in Paediatric Infectious Disease
 
 
 
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j.herberg

 
 
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Location

 

231Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Borensztajn:2022:10.1007/s00431-022-04552-2,
author = {Borensztajn, DM and Hagedoorn, NN and Carrol, ED and von, Both U and Emonts, M and van, der Flier M and de, Groot R and Herberg, J and Kohlmaier, B and Levin, M and Lim, E and Maconochie, IK and Martinon-Torres, F and Nijman, RG and Pokorn, M and Rivero-Calle, I and Tsolia, M and van, der Velden FJS and Vermont, C and Zavadska, D and Zenz, W and Zachariasse, JM and Moll, HA},
doi = {10.1007/s00431-022-04552-2},
journal = {European Journal of Pediatrics},
pages = {3491--3500},
title = {Febrile children with comorbidities at the emergency department - a multicentre observational study},
url = {http://dx.doi.org/10.1007/s00431-022-04552-2},
volume = {181},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We aimed to describe characteristics and management of children with comorbidities attending European emergency departments (EDs) with fever. MOFICHE (Management and Outcome of Fever in children in Europe) is a prospective multicentre study (12 European EDs, 8 countries). Febrile children with comorbidities were compared to those without in terms of patient characteristics, markers of disease severity, management, and diagnosis. Comorbidity was defined as a chronic underlying condition that is expected to last > 1 year. We performed multivariable logistic regression analysis, displaying adjusted odds ratios (aOR), adjusting for patient characteristics. We included 38,110 patients, of whom 5906 (16%) had comorbidities. Most common comorbidities were pulmonary, neurologic, or prematurity. Patients with comorbidities more often were ill appearing (20 versus 16%, p < 0.001), had an ED-Paediatric Early Warning Score of > 15 (22 versus 12%, p < 0.001), or a C-reactive protein > 60 mg/l (aOR 1.4 (95%CI 1.3–1.6)). They more often required life-saving interventions (aOR 2.7, 95% CI 2.2–3.3), were treated with intravenous antibiotics (aOR 2.3, 95%CI 2.1–2.5), and were admitted to the ward (aOR 2.2, 95%CI 2.1–2.4) or paediatric intensive care unit (PICU) (aOR 5.5, 95% CI 3.8–7.9). They were more often diagnosed with serious bacterial infections (aOR 1.8, 95%CI 1.7–2.0), including sepsis/meningitis (aOR 4.6, 95%CI 3.2–6.7). Children most at risk for sepsis/meningitis were children with malignancy/immunodeficiency (aOR 14.5, 8.5–24.8), while children with psychomotor delay/neurological disease were most at risk for life-saving interventions (aOR 5.3, 4.1–6.9) or PICU admission (aOR 9.7, 6.1–15.5).
AU  - Borensztajn,DM
AU  - Hagedoorn,NN
AU  - Carrol,ED
AU  - von,Both U
AU  - Emonts,M
AU  - van,der Flier M
AU  - de,Groot R
AU  - Herberg,J
AU  - Kohlmaier,B
AU  - Levin,M
AU  - Lim,E
AU  - Maconochie,IK
AU  - Martinon-Torres,F
AU  - Nijman,RG
AU  - Pokorn,M
AU  - Rivero-Calle,I
AU  - Tsolia,M
AU  - van,der Velden FJS
AU  - Vermont,C
AU  - Zavadska,D
AU  - Zenz,W
AU  - Zachariasse,JM
AU  - Moll,HA
DO  - 10.1007/s00431-022-04552-2
EP  - 3500
PY  - 2022///
SN  - 0340-6199
SP  - 3491
TI  - Febrile children with comorbidities at the emergency department - a multicentre observational study
T2  - European Journal of Pediatrics
UR  - http://dx.doi.org/10.1007/s00431-022-04552-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000824922300002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007/s00431-022-04552-2
UR  - http://hdl.handle.net/10044/1/98682
VL  - 181
ER  -
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