Dr James Hindley is an EPSRC Doctoral Prize Fellow working in the laboratories of Professor Oscar Ces (Chemistry) and Professor Charlotte Bevan (Surgery and Cancer). His research focuses on the development of soft matter materials at the nano- and micro-scale that can respond to specific stimuli such as temperature, light and chemical/mechanical change for applications including drug delivery, biocatalysis and synthetic biology.
By using chemical and biological motifs to imbue function in self-assembled lipid structures, a toolkit of lipid systems can be created. These can then be combined across length scales to engineer structures capable of functions that mimic cellular behaviour. Building artificial cells from the bottom-up enables a better understanding of cell biology, as well as creating systems that can interface with biological systems. This second property makes artificial cells a promising technology in applications across biomedicine.
James is based in the EPSRC-funded Institute of Chemical Biology - Centre for Doctoral Training, and is associated with the Membrane Biophysics Platform and "CAPITALS" EPSRC Programme Grant.
Engineering patterned thermoresponsive vesicles for content release - Chemical Science
et al., 2022, Dynamic reconfiguration of subcompartment architectures in artificial cells., Acs Nano, ISSN:1936-0851
et al., 2021, Engineering motile aqueous phase-separated droplets via liposome stabilisation, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-11
et al., 2021, Activating mechanosensitive channels embedded in droplet interface bilayers using membrane asymmetry, Chemical Science, Vol:12, ISSN:2041-6520, Pages:2138-2145
et al., 2020, Size dependency of gold nanoparticles interacting with model membranes, Communications Chemistry, Vol:3, ISSN:2399-3669, Pages:1-12
et al., 2020, Membrane protein mediated bilayer communication in networks of droplet interface bilayers, Communications Chemistry, Vol:3, ISSN:2399-3669