Imperial College London

DrJoseJimenez Zarco

Faculty of Natural SciencesDepartment of Life Sciences

Senior Lecturer in Synthetic Biology







Sir Alexander Fleming BuildingSouth Kensington Campus





I am a molecular microbiologist and earned my Ph.D. in 2006 working for the Spanish Research Council (CIB-CSIC) on environmental bacteria for the removal of pollutants. After that I moved into systems and synthetic biology of bacteria in  postdoctoral stays at the National Center for Biotechnology (CSIC; Spain), the Center for Systems Biology at Harvard University (USA) and the Synthetic Biology Center at MIT (USA). 

I was appointed as a Lecturer in Synthetic Biology in the University of Surrey in 2014 and promoted to Senior Lecturer in 2018. I joined the Dpt. of Life Sciences of Imperial College London in 2020. My research is currently sponsored by BBSRC, NERC, the Royal Society, the Leverhulme Foundation and the programme Horizon2020 of the European Union.

My research focuses on a number of topics at the interphase between synthetic biology and evolution. We are interested in understanding how evolution shapes the properties of proteins exhibiting quantum mechanisms in vivo, in the tradeoffs governing gene expression and in the dynamics of complex microbial communities. The applications of this research range from the development of novel methods to fight antibiotic resistant bacterial pathogens to the use of engineered microorganisms for the upcycling of plastic waste into molecules of added value.

For more information please visit my lab webpage.



Narancic T, Salvador M, Hughes GM, et al., 2021, Genome analysis of the metabolically versatile Pseudomonas umsongensis GO16: the genetic basis for PET monomer upcycling into polyhydroxyalkanoates, Microbial Biotechnology, Vol:14, ISSN:1751-7907, Pages:2463-2480

Hidalgo D, Martínez-Ortiz CA, Palsson BO, et al., 2021, Regulatory perturbations of ribosome allocation optimize the growth proteome with a trade-off in adaptation capacity

Kim J, Darlington APS, Bates DG, et al., 2021, The interplay between growth rate and nutrient quality defines gene expression capacity

González J, Salvador M, Özkaya Ö, et al., 2020, The loss of the pyoverdine secondary receptor in Pseudomonas aeruginosa results in a fitter strain suitable for population invasion, The Isme Journal: Multidisciplinary Journal of Microbial Ecology, Vol:15, ISSN:1751-7362, Pages:1330-1343

Lastiri-Pancardo G, Mercado-Hernandez JS, Kim J, et al., 2020, A quantitative method for proteome reallocation using minimal regulatory interventions (Jul, 10.1038/s41589-020-0593-y, 2020), Nature Chemical Biology, Vol:16, ISSN:1552-4450, Pages:1277-1277

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