Imperial College London
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DrJuliaKelly

Faculty of Medicine, National Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 4183j.kelly

 
 
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Location

 

Fulham RoadRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hopkinson:2017:10.1016/j.jamda.2017.09.003,
author = {Hopkinson, NS and tanner},
doi = {10.1016/j.jamda.2017.09.003},
journal = {Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues},
pages = {1097.e11--1097.e24},
title = {Redefining cut-points for high symptom burden of the global initiative for chronic obstructive lung disease classification in 18,577 patients with chronic obstructive pulmonary disease},
url = {http://dx.doi.org/10.1016/j.jamda.2017.09.003},
volume = {18},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPatients with chronic obstructive pulmonary disease (COPD) can be classified into groups A/C or B/D based on symptom intensity. Different threshold values for symptom questionnaires can result in misclassification and, in turn, different treatment recommendations. The primary aim was to find the best fitting cut-points for Global initiative for chronic Obstructive Lung Disease (GOLD) symptom measures, with an modified Medical Research Council dyspnea grade of 2 or higher as point of reference.MethodsAfter a computerized search, data from 41 cohorts and whose authors agreed to provide data were pooled. COPD studies were eligible for analyses if they included, at least age, sex, postbronchodilator spirometry, modified Medical Research Council, and COPD Assessment Test (CAT) total scores.Main outcomesReceiver operating characteristic curves and the Youden index were used to determine the best calibration threshold for CAT, COPD Clinical Questionnaire, and St. Georges Respiratory Questionnaire total scores. Following, GOLD A/B/C/D frequencies were calculated based on current cut-points and the newly derived cut-points.FindingsA total of 18,577 patients with COPD [72.0% male; mean age: 66.3 years (standard deviation 9.6)] were analyzed. Most patients had a moderate or severe degree of airflow limitation (GOLD spirometric grade 1, 10.9%; grade 2, 46.6%; grade 3, 32.4%; and grade 4, 10.3%). The best calibration threshold for CAT total score was 18 points, for COPD Clinical Questionnaire total score 1.9 points, and for St. Georges Respiratory Questionnaire total score 46.0 points.ConclusionsThe application of these new cut-points would reclassify about one-third of the patients with COPD and, thus, would impact on individual disease management. Further validation in prospective studies of these new values are needed.
AU  - Hopkinson,NS
AU  - tanner
DO  - 10.1016/j.jamda.2017.09.003
EP  - 11
PY  - 2017///
SN  - 1525-8610
SP  - 1097
TI  - Redefining cut-points for high symptom burden of the global initiative for chronic obstructive lung disease classification in 18,577 patients with chronic obstructive pulmonary disease
T2  - Journal of the American Medical Directors Association (JAMDA): long-term care: management, applied research and clinical issues
UR  - http://dx.doi.org/10.1016/j.jamda.2017.09.003
UR  - http://hdl.handle.net/10044/1/54239
VL  - 18
ER  -
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