Imperial College London
Dr Julia Kenkre

DrJuliaKenkre

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Research Fellow
 
 
 
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Contact

 

j.kenkre

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kenkre:2021:10.1136/bmjopen-2020-042355,
author = {Kenkre, J and Ahmed, A and Purkayastha, S and Mallalah, K and Bloom, S and Blakemore, A and Prevost, A and Tan, T},
doi = {10.1136/bmjopen-2020-042355},
journal = {BMJ Open},
title = {Who will benefit from bariatric surgery for diabetes? A protocol for an observational cohort study},
url = {http://dx.doi.org/10.1136/bmjopen-2020-042355},
volume = {11},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Type 2 diabetes mellitus (T2DM) and obesity are pandemic diseases that lead to a great deal of morbidity and mortality. The most effective treatment for obesity and T2DM is bariatric or metabolic surgery; it can lead to long-term diabetes remission with 4 in 10 of those undergoing surgery having normal blood glucose on no medication 1 year postoperatively. However, surgery carries risks and, additionally, due to resource limitations, there is a restricted number of patients who can access this treatment. Moreover, not all those who undertake surgery respond equally well metabolically. The objective of the current research is to prospectively investigate predictors of T2DM response following metabolic surgery, including those directly involved in its aetiopathogenesis such as fat distribution and genetic variants. This will inform development of a clinically applicable model to help prioritise this therapy to those predicted to have remission.Methods and analysis A prospective multicentre observational cohort study of adult patients with T2DM and obesity undergoing Roux-en-Y gastric bypass surgery. Patients will be comprehensively assessed before surgery to determine their clinical, metabolic, psychological, genetic and fat distribution profiles. A multivariate logistic regression model will be used to assess the value of the factors derived from the preoperative assessment in terms of prediction of diabetes remission.Ethics and dissemination Formal ethics review was undertaken with a favourable opinion (UK HRA RES reference number 18/LO/0931). The dissemination plan is to present the results at conferences, in peer-reviewed journals as well as to lay media and to patient organisations.Trial registration details ClinicalTrials.gov, Identifier: NCT03842475.
AU  - Kenkre,J
AU  - Ahmed,A
AU  - Purkayastha,S
AU  - Mallalah,K
AU  - Bloom,S
AU  - Blakemore,A
AU  - Prevost,A
AU  - Tan,T
DO  - 10.1136/bmjopen-2020-042355
PY  - 2021///
SN  - 2044-6055
TI  - Who will benefit from bariatric surgery for diabetes? A protocol for an observational cohort study
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2020-042355
UR  - http://hdl.handle.net/10044/1/87213
VL  - 11
ER  -
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