Publications
214 results found
Lindgren CM, Heid IM, Randall JC, et al., 2010, Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, PLOS GENETICS, Vol: 6, ISSN: 1553-7390
Chahal NS, Lim TK, Jain P, et al., 2010, Ethnicity-related differences in left ventricular function, structure and geometry: a population study of UK Indian Asian and European white subjects, HEART, Vol: 96, Pages: 466-471, ISSN: 1355-6037
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- Citations: 66
Al-Lamee RK, Gerber RT, Kooner JS, 2010, Heparin-induced thrombocytopenia (HIT) as an unusual cause of acute stent thrombosis, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 613-613, ISSN: 0195-668X
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- Citations: 3
Chahal NS, Lim TK, Jain P, et al., 2010, New insights into the relationship of left ventricular geometry and left ventricular mass with cardiac function: a population study of hypertensive subjects, EUROPEAN HEART JOURNAL, Vol: 31, Pages: 588-594, ISSN: 0195-668X
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- Citations: 47
Chambers JC, Zhao J, Terracciano CMN, et al., 2010, Genetic variation in <i>SCN10A</i> influences cardiac conduction, NATURE GENETICS, Vol: 42, Pages: 149-U80, ISSN: 1061-4036
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- Citations: 204
Chahal NS, Lim TK, Jain P, et al., 2010, Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study, EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, Vol: 11, Pages: 51-56, ISSN: 1525-2167
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- Citations: 100
Gaemperli O, Liga R, Spyrou N, et al., 2009, Measurement of Myocardial β-Adrenoceptor Density Early After Myocardial Infarction Predicts Incidence of Congestive Heart Failure at Follow Up, Basic Cardiovascular Sciences Conference 2009, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: E60-E60, ISSN: 0009-7330
Williams ED, Steptoe A, Chambers JC, et al., 2009, Psychosocial risk factors for coronary heart disease in UK South Asian men and women, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 63, Pages: 986-991, ISSN: 0143-005X
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- Citations: 17
Zabaneh D, Chambers JC, Elliott P, et al., 2009, Heritability and genetic correlations of insulin resistance and component phenotypes in Asian Indian families using a multivariate analysis, DIABETOLOGIA, Vol: 52, Pages: 2585-2589, ISSN: 0012-186X
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- Citations: 27
Chahal NS, Lim TK, Meldris S, et al., 2009, Increased Carotid Artery Plaque Burden is Associated With Reduced Left Ventricular Function in Asymptomatic Individuals, 82nd Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S377-S377, ISSN: 0009-7322
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- Citations: 1
Chambers JC, Zhang W, Zabaneh D, et al., 2009, Common genetic variation near melatonin receptor mtnr1b contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians, Diabetes, Vol: 58, Pages: 2703-2708, ISSN: 0012-1797
OBJECTIVE Fasting plasma glucose and risk of type 2 diabetes are higher among Indian Asians than among European and North American Caucasians. Few studies have investigated genetic factors influencing glucose metabolism among Indian Asians.RESEARCH DESIGN AND METHODS We carried out genome-wide association studies for fasting glucose in 5,089 nondiabetic Indian Asians genotyped with the Illumina Hap610 BeadChip and 2,385 Indian Asians (698 with type 2 diabetes) genotyped with the Illumina 300 BeadChip. Results were compared with findings in 4,462 European Caucasians.RESULTS We identified three single nucleotide polymorphisms (SNPs) associated with glucose among Indian Asians at P < 5 × 10−8, all near melatonin receptor MTNR1B. The most closely associated was rs2166706 (combined P = 2.1 × 10−9), which is in moderate linkage disequilibrium with rs1387153 (r2 = 0.60) and rs10830963 (r2 = 0.45), both previously associated with glucose in European Caucasians. Risk allele frequency and effect sizes for rs2166706 were similar among Indian Asians and European Caucasians: frequency 46.2 versus 45.0%, respectively (P = 0.44); effect 0.05 (95% CI 0.01–0.08) versus 0.05 (0.03–0.07 mmol/l), respectively, higher glucose per allele copy (P = 0.84). SNP rs2166706 was associated with type 2 diabetes in Indian Asians (odds ratio 1.21 [95% CI 1.06–1.38] per copy of risk allele; P = 0.006). SNPs at the GCK, GCKR, and G6PC2 loci were also associated with glucose among Indian Asians. Risk allele frequencies of rs1260326 (GCKR) and rs560887 (G6PC2) were higher among Indian Asians compared with European Caucasians.CONCLUSIONS Common genetic variation near MTNR1B influences blood glucose and risk of type 2 diabetes in Indian Asians. Genetic variation at the MTNR1B, GCK, GCKR, and G6PC2 loci may contribute to abnormal glucose metabolism and related metabolic disturbances among Indian Asians.
Chambers JC, Zhang W, Li Y, et al., 2009, Genome-wide association study identifies variants in <i>TMPRSS6</i> associated with hemoglobin levels, NATURE GENETICS, Vol: 41, Pages: 1170-1172, ISSN: 1061-4036
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- Citations: 188
Elliott P, Chambers JC, Zhang W, et al., 2009, Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 302, Pages: 37-48, ISSN: 0098-7484
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- Citations: 485
Lindgren CM, Heid IM, Randall JC, et al., 2009, Erratum., PLoS Genet, Vol: 5, ISSN: 1553-7404
[This corrects the article on p. e1000508 in vol. 5, PMID: 19557161.].
Chambers JC, Zhang W, Sehmi J, et al., 2009, COMMON GENETIC VARIATION NEAR MTNR1B CONTRIBUTES TO RAISED PLASMA GLUCOSE AND INCREASED RISK OF TYPE-2 DIABETES AMONG INDIAN ASIANS, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A82-A82, ISSN: 1355-6037
Lindgren CM, Heid IM, Randall JC, et al., 2009, Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution, PLOS GENETICS, Vol: 5, ISSN: 1553-7404
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- Citations: 406
Elliott P, Chambers JC, Zhang W, et al., 2009, GENETIC LOCI INFLUENCING C-REACTIVE PROTEIN LEVELS AND CORONARY HEART DISEASE RISK: RESULTS OF GENETIC ASSOCIATION AND MENDELIAN RANDOMISATION STUDY WITH META-ANALYSIS IN 80 614 PEOPLE, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A61-A61, ISSN: 1355-6037
McHale E, Ahmed N, Sehmi J, et al., 2009, DOES LEFT VIENTRICULAR HYPERTROPHY IDENTIFY THE INCREASED RISK OF CORONARY HEART DISEASE AMONG UK INDIAN ASIANS?, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A33-A34, ISSN: 1355-6037
Chahal NS, Lim TK, Jain P, et al., 2009, ABNORMAL GEOMETRY IS ASSOCIATED WITH MORE SEVERE LEFT VENTRICULAR DYSFUNCTION IN THE PRESENCE OF INCREASED LEFT VENTRICULAR MASS: A POPULATION STUDY, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A75-A76, ISSN: 1355-6037
Sehmi JS, Rai BK, Chambers JC, et al., 2009, DO COMMON GENETIC VARIANTS IN FTO AND MC4R INFLUENCE WEIGHT CHANGE FOLLOWING DIETARY INTERVENTION, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A62-A62, ISSN: 1355-6037
Newton-Cheh C, Johnson T, Gateva V, et al., 2009, Genome-wide association study identifies eight loci associated with blood pressure, Nature Genetics, Vol: 41, Pages: 666-676, ISSN: 1061-4036
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10−24), CYP1A2 (P = 1 × 10−23), FGF5 (P = 1 × 10−21), SH2B3 (P = 3 × 10−18), MTHFR (P = 2 × 10−13), c10orf107 (P = 1 × 10−9), ZNF652 (P = 5 × 10−9) and PLCD3 (P = 1 × 10−8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
Chahal N, Lim TK, Jain P, et al., 2009, Abnormal Geometry With Increased Left Ventricular Mass and Not Concentric Remodelling Is Associated With Abnormal Left Ventricular Function in Hypertensives: A Population Study, 58th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: A212-A213, ISSN: 0735-1097
Kathiresan S, Willer CJ, Peloso GM, et al., 2009, Common variants at 30 loci contribute to polygenic dyslipidemia, NATURE GENETICS, Vol: 41, Pages: 56-65, ISSN: 1061-4036
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- Citations: 1074
Chambers J, Elliott P, Zhang W, et al., 2008, Do Known Genetic Factors Contribute to the Increased Risk of Cardiovascular Disease Amongst Indian Asians?, 81st Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S1101-S1101, ISSN: 0009-7322
Yuan X, Waterworth D, Perry JRB, et al., 2008, Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 83, Pages: 520-528, ISSN: 0002-9297
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- Citations: 336
Nelson MR, Bryc K, King KS, et al., 2008, The population reference sample, POPRES: A resource for population, disease, and pharmacological genetics research, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 83, Pages: 347-358, ISSN: 0002-9297
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- Citations: 186
Williams ED, Steptoe A, Kooner JS, 2008, Psychosocial factors related to cardiovascular disease risk in uk South Asian men and women, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 62, Pages: A18-A19, ISSN: 0143-005X
Sehmi JS, Chambers JC, Kooner JS, 2008, Inflammatory processes are associated with insulin resistance among UK Indian Asians, and not accounted for by obesity, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A38-A39, ISSN: 1355-6037
Chambers JC, Elliott P, Scott J, et al., 2008, Genome-wide association study identifies mlxipl as a novel determinant of trigyceride levels in man, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A5-A5, ISSN: 1355-6037
Zhang W, Zabaneh D, Balding D, et al., 2008, Are Indian Asians genetically homogeneous? Implications for genetic association studies, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A65-A65, ISSN: 1355-6037
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