Imperial College London
Professor Jaspal Kooner

ProfessorJaspalKooner

Faculty of Medicine, National Heart & Lung Institute

Professor Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 3313 4751j.kooner

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dastani:2012:10.1371/journal.pgen.1002607,
author = {Dastani, Z and Hivert, M-F and Timpson, N and Perry, JRB and Yuan, X and Scott, RA and Henneman, P and Heid, IM and Kizer, JR and Lyytikainen, L-P and Fuchsberger, C and Tanaka, T and Morris, AP and Small, K and Isaacs, A and Beekman, M and Coassin, S and Lohman, K and Qi, L and Kanoni, S and Pankow, JS and Uh, H-W and Wu, Y and Bidulescu, A and Rasmussen-Torvik, LJ and Greenwood, CMT and Ladouceur, M and Grimsby, J and Manning, AK and Liu, C-T and Kooner, J and Mooser, VE and Vollenweider, P and Kapur, KA and Chambers, J and Wareham, NJ and Langenberg, C and Frants, R and Willems-vanDijk, K and Oostra, BA and Willems, SM and Lamina, C and Winkler, TW and Psaty, BM and Tracy, RP and Brody, J and Chen, I and Viikari, J and Kahonen, M and Pramstaller, PP and Evans, DM and St, Pourcain B and Sattar, N and Wood, AR and Bandinelli, S and Carlson, OD and Egan, JM and Bohringer, S and van, Heemst D and Kedenko, L and Kristiansson, K and Nuotio, M-L and Loo, B-M and Harris, T and Garcia, M and},
doi = {10.1371/journal.pgen.1002607},
journal = {PLOS Genetics},
title = {Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals},
url = {http://dx.doi.org/10.1371/journal.pgen.1002607},
volume = {8},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inverselyassociated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wideassociation studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. Weidentified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.561028–1.2610243). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, andN = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samplesrevealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations afteraccounting for multiple testing (p,361024). We next developed a multi-SNP genotypic risk score to test the associationof adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This riskscore was associated with increased risk of T2D (p = 4.361023, n = 22,044), increased triglycerides (p = 2.6610214,n = 93,440), increased waist-to-hip ratio (p = 1.861025, n = 77,167), increased glucose two hours post oral glucosetolerance testing (p = 4.461023, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDLcholesterolconcentrations (p = 4.5610213, n = 96,748) and decreased BMI (p = 1.461024, n = 121,335). These findingsidentify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers ofinsulin resistance.
AU  - Dastani,Z
AU  - Hivert,M-F
AU  - Timpson,N
AU  - Perry,JRB
AU  - Yuan,X
AU  - Scott,RA
AU  - Henneman,P
AU  - Heid,IM
AU  - Kizer,JR
AU  - Lyytikainen,L-P
AU  - Fuchsberger,C
AU  - Tanaka,T
AU  - Morris,AP
AU  - Small,K
AU  - Isaacs,A
AU  - Beekman,M
AU  - Coassin,S
AU  - Lohman,K
AU  - Qi,L
AU  - Kanoni,S
AU  - Pankow,JS
AU  - Uh,H-W
AU  - Wu,Y
AU  - Bidulescu,A
AU  - Rasmussen-Torvik,LJ
AU  - Greenwood,CMT
AU  - Ladouceur,M
AU  - Grimsby,J
AU  - Manning,AK
AU  - Liu,C-T
AU  - Kooner,J
AU  - Mooser,VE
AU  - Vollenweider,P
AU  - Kapur,KA
AU  - Chambers,J
AU  - Wareham,NJ
AU  - Langenberg,C
AU  - Frants,R
AU  - Willems-vanDijk,K
AU  - Oostra,BA
AU  - Willems,SM
AU  - Lamina,C
AU  - Winkler,TW
AU  - Psaty,BM
AU  - Tracy,RP
AU  - Brody,J
AU  - Chen,I
AU  - Viikari,J
AU  - Kahonen,M
AU  - Pramstaller,PP
AU  - Evans,DM
AU  - St,Pourcain B
AU  - Sattar,N
AU  - Wood,AR
AU  - Bandinelli,S
AU  - Carlson,OD
AU  - Egan,JM
AU  - Bohringer,S
AU  - van,Heemst D
AU  - Kedenko,L
AU  - Kristiansson,K
AU  - Nuotio,M-L
AU  - Loo,B-M
AU  - Harris,T
AU  - Garcia,M
AU  - Kanaya,A
AU  - Haun,M
AU  - Klopp,N
AU  - Wichmann,H-E
AU  - Deloukas,P
AU  - Katsareli,E
AU  - Couper,DJ
AU  - Duncan,BB
AU  - Kloppenburg,M
AU  - Adair,LS
AU  - Borja,JB
AU  - Wilson,JG
AU  - Musani,S
AU  - Guo,X
AU  - Johnson,T
AU  - Semple,R
AU  - Teslovich,TM
AU  - Allison,MA
AU  - Redline,S
AU  - Buxbaum,SG
AU  - Mohlke,KL
AU  - Meulenbelt,I
AU  - Ballantyne,CM
AU  - Dedoussis,GV
AU  - Hu,FB
AU  - Liu,Y
AU  - Paulweber,B
AU  - Spector,TD
AU  - Slagboom,PE
AU  - Ferrucci,L
AU  - Jula,A
AU  - Perola,M
AU  - Raitakari,O
AU  - Florez,JC
AU  - Salomaa,V
AU  - Eriksson,JG
AU  - Frayling,TM
AU  - Hicks,AA
AU  - Lehtimaki,T
AU  - Smith,GD
AU  - Siscovick,DS
AU  - Kronenberg,F
AU  - van,Duijn C
AU  - Loos,RJF
AU  - Waterworth,DM
AU  - Meigs,JB
AU  - Dupuis,J
AU  - Richards,JB
DO  - 10.1371/journal.pgen.1002607
PY  - 2012///
SN  - 1553-7390
TI  - Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
T2  - PLOS Genetics
UR  - http://dx.doi.org/10.1371/journal.pgen.1002607
UR  - http://hdl.handle.net/10044/1/28916
VL  - 8
ER  -
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