Imperial College London
Professor Jaspal Kooner

ProfessorJaspalKooner

Faculty of Medicine, National Heart & Lung Institute

Professor Clinical Cardiology
 
 
 
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Contact

 

+44 (0)20 3313 4751j.kooner

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Willer:2013:10.1038/ng.2797,
author = {Willer, CJ and Schmidt, EM and Sengupta, S and Peloso, GM and Gustafsson, S and Kanoni, S and Ganna, A and Chen, J and Buchkovich, ML and Mora, S and Beckmann, JS and Bragg-Gresham, JL and Chang, H-Y and Demirkan, A and Den, Hertog HM and Do, R and Donnelly, LA and Ehret, GB and Esko, T and Feitosa, MF and Ferreira, T and Fischer, K and Fontanillas, P and Fraser, RM and Freitag, DF and Gurdasani, D and Heikkila, K and Hyppoenen, E and Isaacs, A and Jackson, AU and Johansson, A and Johnson, T and Kaakinen, M and Kettunen, J and Kleber, ME and Li, X and Luan, J and Lyytikainen, L-P and Magnusson, PKE and Mangino, M and Mihailov, E and Montasser, ME and Mueller-Nurasyid, M and Nolte, IM and O'Connell, JR and Palmer, CD and Perola, M and Petersen, A-K and Sanna, S and Saxena, R and Service, SK and Shah, S and Shungin, D and Sidore, C and Song, C and Strawbridge, RJ and Surakka, I and Tanaka, T and Teslovich, TM and Thorleifsson, G and Van, den Herik EG and Voight, BF and Volcik, KA and Wai},
doi = {10.1038/ng.2797},
journal = {Nature Genetics},
pages = {1274--1283},
title = {Discovery and refinement of loci associated with lipid levels},
url = {http://dx.doi.org/10.1038/ng.2797},
volume = {45},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10−8, including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
AU  - Willer,CJ
AU  - Schmidt,EM
AU  - Sengupta,S
AU  - Peloso,GM
AU  - Gustafsson,S
AU  - Kanoni,S
AU  - Ganna,A
AU  - Chen,J
AU  - Buchkovich,ML
AU  - Mora,S
AU  - Beckmann,JS
AU  - Bragg-Gresham,JL
AU  - Chang,H-Y
AU  - Demirkan,A
AU  - Den,Hertog HM
AU  - Do,R
AU  - Donnelly,LA
AU  - Ehret,GB
AU  - Esko,T
AU  - Feitosa,MF
AU  - Ferreira,T
AU  - Fischer,K
AU  - Fontanillas,P
AU  - Fraser,RM
AU  - Freitag,DF
AU  - Gurdasani,D
AU  - Heikkila,K
AU  - Hyppoenen,E
AU  - Isaacs,A
AU  - Jackson,AU
AU  - Johansson,A
AU  - Johnson,T
AU  - Kaakinen,M
AU  - Kettunen,J
AU  - Kleber,ME
AU  - Li,X
AU  - Luan,J
AU  - Lyytikainen,L-P
AU  - Magnusson,PKE
AU  - Mangino,M
AU  - Mihailov,E
AU  - Montasser,ME
AU  - Mueller-Nurasyid,M
AU  - Nolte,IM
AU  - O'Connell,JR
AU  - Palmer,CD
AU  - Perola,M
AU  - Petersen,A-K
AU  - Sanna,S
AU  - Saxena,R
AU  - Service,SK
AU  - Shah,S
AU  - Shungin,D
AU  - Sidore,C
AU  - Song,C
AU  - Strawbridge,RJ
AU  - Surakka,I
AU  - Tanaka,T
AU  - Teslovich,TM
AU  - Thorleifsson,G
AU  - Van,den Herik EG
AU  - Voight,BF
AU  - Volcik,KA
AU  - Waite,LL
AU  - Wong,A
AU  - Wu,Y
AU  - Zhang,W
AU  - Absher,D
AU  - Asiki,G
AU  - Barroso,I
AU  - Been,LF
AU  - Bolton,JL
AU  - Bonnycastle,LL
AU  - Brambilla,P
AU  - Burnett,MS
AU  - Cesana,G
AU  - Dimitriou,M
AU  - Doney,ASF
AU  - Doering,A
AU  - Elliott,P
AU  - Epstein,SE
AU  - Eyjolfsson,GI
AU  - Gigante,B
AU  - Goodarzi,MO
AU  - Grallert,H
AU  - Gravito,ML
AU  - Groves,CJ
AU  - Hallmans,G
AU  - Hartikainen,A-L
AU  - Hayward,C
AU  - Hernandez,D
AU  - Hicks,AA
AU  - Holm,H
AU  - Hung,Y-J
AU  - Illig,T
AU  - Jones,MR
AU  - Kaleebu,P
AU  - Kastelein,JJP
AU  - Khaw,K-T
AU  - Kim,E
AU  - Klopp,N
AU  - Komulainen,P
AU  - Kumari,M
AU  - Langenberg,C
AU  - Lehtimaki,T
AU  - Lin,S-Y
AU  - Lindstrom,J
AU  - Loos,RJF
AU  - Mach,F
AU  - McArdle,WL
AU  - Meisinger,C
AU  - Mitchell,BD
AU  - Mueller,G
AU  - Nagaraja,R
AU  - Narisu,N
AU  - Nieminen,TVM
AU  - Nsubuga,RN
AU  - Olafsson,I
AU  - Ong,KK
AU  - Palotie,A
AU  - Papamarkou,T
AU  - Pomilla,C
AU  - Pouta,A
AU  - Rader,DJ
AU  - Reilly,MP
AU  - Ridker,PM
AU  - Rivadeneira,F
AU  - Rudan,I
AU  - Ruokonen,A
AU  - Samani,N
AU  - Scharnagl,H
AU  - Seeley,J
AU  - Silander,K
AU  - Stancakova,A
AU  - Stirrups,K
AU  - Swift,AJ
AU  - Tiret,L
AU  - Uitterlinden,AG
AU  - van,Pelt LJ
AU  - Vedantam,S
AU  - Wainwright,N
AU  - Wijmenga,C
AU  - Wild,SH
AU  - Willemsen,G
AU  - Wilsgaard,T
AU  - Wilson,JF
AU  - Young,EH
AU  - Zhao,JH
AU  - Adair,LS
AU  - Arveiler,D
AU  - Assimes,TL
AU  - Bandinelli,S
AU  - Bennett,F
AU  - Bochud,M
AU  - Boehm,BO
AU  - Boomsma,DI
AU  - Borecki,IB
AU  - Bornstein,SR
AU  - Bovet,P
AU  - Burnier,M
AU  - Campbell,H
AU  - Chakravarti,A
AU  - Chambers,JC
AU  - Chen,Y-DI
AU  - Collins,FS
AU  - Cooper,RS
AU  - Danesh,J
AU  - Dedoussis,G
AU  - de,Faire U
AU  - Feranil,AB
AU  - Ferrieres,J
AU  - Ferrucci,L
AU  - Freimer,NB
DO  - 10.1038/ng.2797
EP  - 1283
PY  - 2013///
SN  - 1061-4036
SP  - 1274
TI  - Discovery and refinement of loci associated with lipid levels
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.2797
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326384100007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/ng.2797
UR  - http://hdl.handle.net/10044/1/72524
VL  - 45
ER  -
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