Imperial College London
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DrJonathanKrell

Faculty of Medicine, Department of Surgery & Cancer

Clinical SL in Medical Oncology (Gynaecological Oncology)
 
 
 
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Contact

 

j.krell

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Merali:2022:10.3390/cancers14041020,
author = {Merali, N and Chouari, T and Kayani, K and Rayner, C and Jimenez, Zarco J and Giovannetti, E and Krell, J and Bagwan, I and Relph, K and Rockall, T and Dhillon, T and Pandha, H and Annels, N and Frampton, A},
doi = {10.3390/cancers14041020},
journal = {Cancers},
pages = {1--34},
title = {A comprehensive review of the current and future role of the microbiome in pancreatic ductal adenocarcinoma},
url = {http://dx.doi.org/10.3390/cancers14041020},
volume = {14},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second most common cause of cancer death in the USA by 2030, yet progress continues to lag behind that of other cancers, with only 9% of patients surviving beyond 5 years. Long-term survivorship of PDAC and improving survival has, until recently, escaped our understanding. One recent frontier in the cancer field is the microbiome. The microbiome collectively refers to the extensive community of bacteria and fungi that colonise us. It is estimated that there is one to ten prokaryotic cells for each human somatic cell, yet, the significance of this community in health and disease has, until recently, been overlooked. This review examines the role of the microbiome in PDAC and how it may alter survival outcomes. We evaluate the possibility of employing microbiomic signatures as biomarkers of PDAC. Ultimately this review analyses whether the microbiome may be amenable to targeting and consequently altering the natural history of PDAC.
AU  - Merali,N
AU  - Chouari,T
AU  - Kayani,K
AU  - Rayner,C
AU  - Jimenez,Zarco J
AU  - Giovannetti,E
AU  - Krell,J
AU  - Bagwan,I
AU  - Relph,K
AU  - Rockall,T
AU  - Dhillon,T
AU  - Pandha,H
AU  - Annels,N
AU  - Frampton,A
DO  - 10.3390/cancers14041020
EP  - 34
PY  - 2022///
SN  - 2072-6694
SP  - 1
TI  - A comprehensive review of the current and future role of the microbiome in pancreatic ductal adenocarcinoma
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers14041020
UR  - https://www.mdpi.com/2072-6694/14/4/1020
UR  - http://hdl.handle.net/10044/1/95118
VL  - 14
ER  -
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