Imperial College London
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DrJonathanKrell

Faculty of Medicine, Department of Surgery & Cancer

Clinical SL in Medical Oncology (Gynaecological Oncology)
 
 
 
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j.krell

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Constantinou:2022:10.1021/acs.macromol.1c02123,
author = {Constantinou, AP and Nele, V and Doutch, JJ and S, Correia J and Moiseev, RV and Cihova, M and Gaboriau, DCA and Krell, J and Khutoryanskiy, VV and Stevens, MM and Georgiou, TK},
doi = {10.1021/acs.macromol.1c02123},
journal = {Macromolecules},
pages = {1783--1799},
title = {Investigation of the thermogelation of a promising biocompatible ABC triblock terpolymer and its comparison with pluronic F127},
url = {http://dx.doi.org/10.1021/acs.macromol.1c02123},
volume = {55},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Thermoresponsive polymers with the appropriate structure form physical networks upon changes in temperature, and they find utility in formulation science, tissue engineering, and drug delivery. Here, we report a cost-effective biocompatible alternative, namely OEGMA30015-b-BuMA26-b-DEGMA13, which forms gels at low concentrations (as low as 2% w/w); OEGMA300, BuMA, and DEGMA stand for oligo(ethylene glycol) methyl ether methacrylate (MM = 300 g mol–1), n-butyl methacrylate, and di(ethylene glycol) methyl ether methacrylate, respectively. This polymer is investigated in depth and is compared to its commercially available counterpart, Poloxamer P407 (Pluronic F127). To elucidate the differences in their macroscale gelling behavior, we investigate their nanoscale self-assembly by means of small-angle neutron scattering and simultaneously recording their rheological properties. Two different gelation mechanisms are revealed. The triblock copolymer inherently forms elongated micelles, whose length increases by temperature to form worm-like micelles, thus promoting gelation. In contrast, Pluronic F127’s micellization is temperature-driven, and its gelation is attributed to the close packing of the micelles. The gel structure is analyzed through cryogenic scanning and transmission electron microscopy. Ex vivo gelation study upon intracameral injections demonstrates excellent potential for its application to improve drug residence in the eye.
AU  - Constantinou,AP
AU  - Nele,V
AU  - Doutch,JJ
AU  - S,Correia J
AU  - Moiseev,RV
AU  - Cihova,M
AU  - Gaboriau,DCA
AU  - Krell,J
AU  - Khutoryanskiy,VV
AU  - Stevens,MM
AU  - Georgiou,TK
DO  - 10.1021/acs.macromol.1c02123
EP  - 1799
PY  - 2022///
SN  - 0024-9297
SP  - 1783
TI  - Investigation of the thermogelation of a promising biocompatible ABC triblock terpolymer and its comparison with pluronic F127
T2  - Macromolecules
UR  - http://dx.doi.org/10.1021/acs.macromol.1c02123
UR  - https://pubs.acs.org/doi/10.1021/acs.macromol.1c02123
UR  - http://hdl.handle.net/10044/1/95021
VL  - 55
ER  -
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