Imperial College London
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DrJonathanKrell

Faculty of Medicine, Department of Surgery & Cancer

Clinical SL in Medical Oncology (Gynaecological Oncology)
 
 
 
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j.krell

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cunnea:2023:10.1016/j.xcrm.2023.101055,
author = {Cunnea, P and Curry, EW and Christie, EL and Nixon, K and Kwok, CH and Pandey, A and Wulandari, R and Thol, K and Ploski, J and Morera-Albert, C and McQuaid, S and Lozano-Kuehne, J and Clark, JJ and Krell, J and Stronach, EA and McNeish, IA and Bowtell, DDL and Fotopoulou, C},
doi = {10.1016/j.xcrm.2023.101055},
journal = {Cell Reports Medicine},
pages = {1--20},
title = {Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: implications for surgical and clinical outcomes},
url = {http://dx.doi.org/10.1016/j.xcrm.2023.101055},
volume = {4},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Limited evidence exists on the impact of spatial and temporal heterogeneity of high-grade serous ovarian cancer (HGSOC) on tumor evolution, clinical outcomes, and surgical operability. We perform systematic multi-site tumor mapping at presentation and matched relapse from 49 high-tumor-burden patients, operated up front. From SNP array-derived copy-number data, we categorize dendrograms representing tumor clonal evolution as sympodial or dichotomous, noting most chemo-resistant patients favor simpler sympodial evolution. Three distinct tumor evolutionary patterns from primary to relapse are identified, demonstrating recurrent disease may emerge from pre-existing or newly detected clones. Crucially, we identify spatial heterogeneity for clinically actionable homologous recombination deficiency scores and for poor prognosis biomarkers CCNE1 and MYC. Copy-number signature, phenotypic, proteomic, and proliferative-index heterogeneity further highlight HGSOC complexity. This study explores HGSOC evolution and dissemination across space and time, its impact on optimal surgical cytoreductive effort and clinical outcomes, and its consequences for clinical decision-making.
AU  - Cunnea,P
AU  - Curry,EW
AU  - Christie,EL
AU  - Nixon,K
AU  - Kwok,CH
AU  - Pandey,A
AU  - Wulandari,R
AU  - Thol,K
AU  - Ploski,J
AU  - Morera-Albert,C
AU  - McQuaid,S
AU  - Lozano-Kuehne,J
AU  - Clark,JJ
AU  - Krell,J
AU  - Stronach,EA
AU  - McNeish,IA
AU  - Bowtell,DDL
AU  - Fotopoulou,C
DO  - 10.1016/j.xcrm.2023.101055
EP  - 20
PY  - 2023///
SN  - 2666-3791
SP  - 1
TI  - Spatial and temporal intra-tumoral heterogeneity in advanced HGSOC: implications for surgical and clinical outcomes
T2  - Cell Reports Medicine
UR  - http://dx.doi.org/10.1016/j.xcrm.2023.101055
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37220750
UR  - https://www.sciencedirect.com/science/article/pii/S2666379123001696
UR  - http://hdl.handle.net/10044/1/104322
VL  - 4
ER  -
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