Imperial College London
Alternate

Krishnan

Faculty of Engineering, Department of Chemical Engineering

Reader in Biological&Chemical Information Processing Systems
 
 
 
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Contact

 

+44 (0)20 7594 6633j.krishnan

 
 
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Location

 

C503Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Krishnan:2018:10.1098/rsif.2018.0109,
author = {Krishnan, J and Suwanmajo, T},
doi = {10.1098/rsif.2018.0109},
journal = {Journal of the Royal Society Interface},
pages = {1--26},
title = {Exploring the intrinsic behaviour of multisite phosphorylation systems as part of signalling pathways},
url = {http://dx.doi.org/10.1098/rsif.2018.0109},
volume = {15},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Multisite phosphorylation is a basic way of chemically encoding substrate function and a recurring feature of cell signalling pathways. A number of studies have explored information processing characteristics of multisite phosphorylation, through studies of the intrinsic kinetics. Many of these studies focus on the module in isolation. In this paper, we build a bridge to connect the behaviour of multisite modification in isolation to that as part of pathways. We study the effect of activation of the enzymes (which are basic ways in which the module may be regulated), as well the effects of the modified substrates being involved in further modifications or exiting reaction compartments. We find that these effects can induce multiple kinds of transitions, including to behaviour not seen intrinsically in the multisite modification module. We then build on these insights to investigate how these multisite modification systems can be tuned by enzyme activation to realize a range of information processing outcomes for the design of synthetic phosphorylation circuits. Connecting the complexity of multisite modification kinetics, with the pathways in which they are embedded, serves as a basis for teasing out many aspects of their interaction, providing insights of relevance in systems biology, synthetic biology/chemistry and chemical information processing.
AU  - Krishnan,J
AU  - Suwanmajo,T
DO  - 10.1098/rsif.2018.0109
EP  - 26
PY  - 2018///
SN  - 1742-5662
SP  - 1
TI  - Exploring the intrinsic behaviour of multisite phosphorylation systems as part of signalling pathways
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2018.0109
UR  - https://royalsocietypublishing.org/doi/10.1098/rsif.2018.0109
UR  - http://hdl.handle.net/10044/1/60297
VL  - 15
ER  -
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