Imperial College London
Alternate

Krishnan

Faculty of Engineering, Department of Chemical Engineering

Reader in Biological&Chemical Information Processing Systems
 
 
 
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Contact

 

+44 (0)20 7594 6633j.krishnan

 
 
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Location

 

C503Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ramesh:2021:10.7554/eLife.65358,
author = {Ramesh, V and Krishnan, J},
doi = {10.7554/eLife.65358},
journal = {eLife},
pages = {1--57},
title = {Symmetry breaking meets multisite modification},
url = {http://dx.doi.org/10.7554/eLife.65358},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Multisite modification is a basic way of conferring functionality to proteins, and a key component of post-translational modification networks. Additional interest in multisite modification stems from its capability of acting as complex information processors. In this paper we connect two seemingly disparate themes: symmetry and multisite modification. We examine different classes of random modification networks of substrates involving separate or common enzymes. We demonstrate that under different instances of symmetry of the modification network (invoked explicitly or implicitly and discussed in the literature), the biochemistry of multisite modification can lead to the symmetry being broken. This is shown computationally and consolidated analytically, revealing parameter regions where this can (and in fact does) happen, and characteristics of the symmetry broken state. We discuss the relevance of these results in situations where exact symmetry is not present. Overall, through our study we show how symmetry breaking (i) can confer new capabilities to protein networks, including concentration robustness of different combinations of species (in conjunction with multiple steady states) (ii) could have been the basis for ordering of multisite modification, which is widely observed in cells (iii) can significantly impact information processing in multisite modification and in cell signalling networks/pathways where multisite modification is present (iv) can be a fruitful new angle for engineering in synthetic biology and chemistry. All in all, the emerging conceptual synthesis provides a new vantage point for the elucidation and the engineering of molecular systems at the junction of chemical and biological systems.
AU  - Ramesh,V
AU  - Krishnan,J
DO  - 10.7554/eLife.65358
EP  - 57
PY  - 2021///
SN  - 2050-084X
SP  - 1
TI  - Symmetry breaking meets multisite modification
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.65358
UR  - https://elifesciences.org/articles/65358
UR  - http://hdl.handle.net/10044/1/90000
VL  - 10
ER  -
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