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@article{Menon:2021:10.1038/s41467-021-24760-y,
author = {Menon, G and Krishnan, J},
doi = {10.1038/s41467-021-24760-y},
journal = {Nature Communications},
pages = {1--21},
title = {Spatial localization meets biomolecular networks},
url = {http://dx.doi.org/10.1038/s41467-021-24760-y},
volume = {12},
year = {2021}
}

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TY  - JOUR
AB  - Spatial organization through localization/compartmentalization of species is a ubiquitous but poorlyunderstood feature of cellular biomolecular networks. Current technologies in systems and syntheticbiology (spatial proteomics, imaging, synthetic compartmentalization) necessitate a systematicapproach to elucidating the interplay of networks and spatial organization. We develop a systemsframework towards this end and focus on the effect of spatial localization of network componentsrevealing its multiple facets: (i) As a key distinct regulator of network behaviour, and an enabler of newnetwork capabilities (ii) As a potent new regulator of pattern formation and self-organization (iii) As anoften hidden factor impacting inference of temporal networks from data (iv) As an engineering tool forrewiring networks and network/circuit design. These insights, transparently arising from the most basicconsiderations of networks and spatial organization, have broad relevance in natural and engineeredbiology and in related areas such as cell-free systems, systems chemistry and bionanotechnology
AU  - Menon,G
AU  - Krishnan,J
DO  - 10.1038/s41467-021-24760-y
EP  - 21
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Spatial localization meets biomolecular networks
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-24760-y
UR  - https://www.nature.com/articles/s41467-021-24760-y
UR  - http://hdl.handle.net/10044/1/90770
VL  - 12
ER  -

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