Imperial College London
Alternate

Krishnan

Faculty of Engineering, Department of Chemical Engineering

Reader in Biological&Chemical Information Processing Systems
 
 
 
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Contact

 

+44 (0)20 7594 6633j.krishnan

 
 
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Location

 

C503Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Alam-Nazki:2015:10.1016/j.bpj.2015.05.012,
author = {Alam-Nazki, A and Krishnan, J},
doi = {10.1016/j.bpj.2015.05.012},
journal = {Biophysical Journal},
pages = {2912--2924},
title = {Spatial control of  biochemical modification cascades and pathways},
url = {http://dx.doi.org/10.1016/j.bpj.2015.05.012},
volume = {108},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Information transmission in cells occurs through complex networks of proteins and genes and is relayed through cascades of biochemical modifications, which are typically studied through ordinary differential equations. However, it is becoming increasingly clear that spatial factors can strongly influence chemical information transmission in cells. In this article, we systematically disentangle the effects of space in signaling cascades. This is done by examining the effects of localization/compartmentalization and diffusion of enzymes and substrates in multiple variants of chemical modification cascades. This includes situations where the modified form of species at one stage 1) acts as an enzyme for the next stage; 2) acts as a substrate for the next stage; and 3) is involved in phosphotransfer. Our analysis reveals the multiple effects of space in signal transduction cascades. Although in some cases space plays a modulatory effect (itself of interest), in other cases, spatial regulation and control can profoundly affect the nature of information processing as a result of the subtle interplay between the patterns of localization of species, diffusion, and the nature of the modification cascades. Our results provide a platform for disentangling the role of space and spatial control in multiple cellular contexts and a basis for engineering spatial control in signaling cascades through localization/compartmentalization.
AU  - Alam-Nazki,A
AU  - Krishnan,J
DO  - 10.1016/j.bpj.2015.05.012
EP  - 2924
PY  - 2015///
SN  - 0006-3495
SP  - 2912
TI  - Spatial control of  biochemical modification cascades and pathways
T2  - Biophysical Journal
UR  - http://dx.doi.org/10.1016/j.bpj.2015.05.012
VL  - 108
ER  -
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