Imperial College London
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DrJuliaMakinde

Faculty of Medicine, Department of Infectious Disease

Honorary Lecturer
 
 
 
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Contact

 

j.makinde

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clement:2016:10.1038/srep35332,
author = {Clement, M and Pearson, JA and Gras, S and van, den Berg HA and Lissina, A and Llewellyn-Lacey, S and Willis, MD and Dockree, T and McLaren, JE and Ekeruche-Makinde, J and Gostick, E and Robertson, NP and Rossjohn, J and Burrows, SR and Price, DA and Wong, FS and Peakman, M and Skowera, A and Wooldridge, L},
doi = {10.1038/srep35332},
journal = {Scientific Reports},
title = {Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies},
url = {http://dx.doi.org/10.1038/srep35332},
volume = {6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - CD8+ T-cells play a role in the pathogenesis of autoimmune diseases such as multiple sclerosis and type 1 diabetes. However, drugs that target the entire CD8+ T-cell population are not desirable because the associated lack of specificity can lead to unwanted consequences, most notably an enhanced susceptibility to infection. Here, we show that autoreactive CD8+ T-cells are highly dependent on CD8 for ligand-induced activation via the T-cell receptor (TCR). In contrast, pathogen-specific CD8+ T-cells are relatively CD8-independent. These generic differences relate to an intrinsic dichotomy that segregates self-derived and exogenous antigen-specific TCRs according to the monomeric interaction affinity with cognate peptide-major histocompatibility complex class I (pMHCI). As a consequence, “blocking” anti-CD8 antibodies can suppress autoreactive CD8+ T-cell activation in a relatively selective manner. These findings provide a rational basis for the development and in vivo assessment of novel therapeutic strategies that preferentially target disease-relevant autoimmune responses within the CD8+ T-cell compartment.
AU  - Clement,M
AU  - Pearson,JA
AU  - Gras,S
AU  - van,den Berg HA
AU  - Lissina,A
AU  - Llewellyn-Lacey,S
AU  - Willis,MD
AU  - Dockree,T
AU  - McLaren,JE
AU  - Ekeruche-Makinde,J
AU  - Gostick,E
AU  - Robertson,NP
AU  - Rossjohn,J
AU  - Burrows,SR
AU  - Price,DA
AU  - Wong,FS
AU  - Peakman,M
AU  - Skowera,A
AU  - Wooldridge,L
DO  - 10.1038/srep35332
PY  - 2016///
SN  - 2045-2322
TI  - Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/srep35332
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000385356300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/50233
VL  - 6
ER  -
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