Julian Marchesi graduated from Cardiff University with a PhD in biochemistry (1992) and became interested in the role bacteria play in ecosystem function. During his post-doctoral years he developed an interest in the contribution of uncultured microbes to the maintenance and function of ecosystems i.e. molecular microbial ecology. He subsequently secured a Wellcome Trust Fellowship which extended his molecular microbial ecology interest and investigated, with culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants in pristine environments. After a short time investigating the deep biosphere he obtained a Lectureship (2001) in the Department of Microbiology, University College Cork, Ireland where he transferred these “omic” skills into the human gut and started to investigate the human gut ecosystem in health and disease. After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system. In 2015 he was promoted to Professor at Cardiff and in 2016 to Professor at Imperial College London.
His work uses a variety of “omic” approaches such as metagenomics, metatranscriptomics, metabonomics and molecular ecology. Over his 22 year career he has authored over 190 journal articles and peer-reviewed publications and is a senior editor for ISME Journal. He is the current chair of the BSG's Gut Microbiota for Health Expert Panel and chaired the Microbiology Society's "Unlocking the Microbiome " working group and the subsequent publication.
et al., 2022, The association of weight loss with changes in the gut microbiota diversity, composition, and intestinal permeability: a systematic review and meta-analysis, Gut Microbes, Vol:14, ISSN:1949-0976
et al., 2022, The impact of almonds and almond processing on gastrointestinal physiology, luminal mand gastrointestinal symptoms: a randomized controlled trial and mastication study., American Journal of Clinical Nutrition, ISSN:0002-9165
et al., 2022, Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity, Communications Medicine, ISSN:2730-664X
Mullish BH, McDonald JAK, Marchesi JR, 2022, Mechanisms of efficacy of intestinal microbiota transplant: do not forget the metabolites, The Lancet Gastroenterology & Hepatology, Vol:7, ISSN:2468-1253, Pages:594-594
et al., 2022, Fecal bile acid profiles predict recurrence in patients with primary <i>Clostridioides difficile</i> infection