Julian Marchesi graduated from Cardiff University with a PhD in biochemistry (1992) and became interested in the role bacteria play in ecosystem function. During his post-doctoral years he developed an interest in the contribution of uncultured microbes to the maintenance and function of ecosystems i.e. molecular microbial ecology. He subsequently secured a Wellcome Trust Fellowship which extended his molecular microbial ecology interest and investigated, with culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants in pristine environments. After a short time investigating the deep biosphere he obtained a Lectureship (2001) in the Department of Microbiology, University College Cork, Ireland where he transferred these “omic” skills into the human gut and started to investigate the human gut ecosystem in health and disease. After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system. In 2015 he was promoted to Professor at Cardiff and in 2016 to Professor at Imperial College London.
His work uses a variety of “omic” approaches such as metagenomics, metatranscriptomics, metabonomics and molecular ecology. Over his 22 year career he has authored over 190 journal articles and peer-reviewed publications and is a senior editor for ISME Journal. He is the current chair of the BSG's Gut Microbiota for Health Expert Panel and chaired the Microbiology Society's "Unlocking the Microbiome " working group and the subsequent publication.
et al., 2021, Disease prevention not decolonization – a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms, Clinical Infectious Diseases, Vol:72, ISSN:1058-4838, Pages:1444-1447
et al., 2021, Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?, Gut Microbes, ISSN:1949-0976
et al., 2021, Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease., Microbiome, Vol:9
et al., 2021, Lactobacillus-depleted vaginal microbiota in pregnant women living with HIV-1 infection are associated with increased local inflammation and preterm birth, Frontiers in Cellular and Infection Microbiology, Vol:10, ISSN:2235-2988
et al., 2021, Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss, Gut Microbes, Vol:13, ISSN:1949-0976, Pages:1-20