Imperial College London
Alternate

ProfessorJulianMarchesi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Digestive Health
 
 
 
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Contact

 

+44 (0)20 3312 6197j.marchesi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Creedon:2022:ajcn/nqac265,
author = {Creedon, AC and Dimidi, E and Hung, ES and Rossi, M and Probert, C and Grassby, T and Miguens-Blanco, J and Marchesi, JR and Scott, SM and Berry, SE and Whelan, K},
doi = {ajcn/nqac265},
journal = {American Journal of Clinical Nutrition},
pages = {1790--1804},
title = {The impact of almonds and almond processing on gastrointestinal physiology, luminal mand gastrointestinal symptoms: a randomized controlled trial and mastication study.},
url = {http://dx.doi.org/10.1093/ajcn/nqac265},
volume = {116},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Almonds contain lipid, fiber and polyphenols and possess physicochemical properties that impact nutrient bioaccessibility, which are hypothesized to impact gut physiology and microbiota. OBJECTIVES: Investigate the impact of whole almonds and ground almonds (almond flour) on fecal bifidobacteria (primary outcome), gut microbiota composition and transit time. DESIGN: Healthy adults (n = 87) participated in a parallel, 3-arm randomized controlled trial. Participants received whole almonds (56 g/d), ground almonds (56 g/d) or an isocaloric control muffin in place of habitual snacks for 4 weeks. Gut microbiota composition and diversity (16S rRNA gene sequencing), short-chain fatty acids (gas-chromatography), volatile organic compounds (gas-chromatography mass-spectrometry), gut transit time (wireless motility capsule), stool output and gut symptoms (7-day diary) were measured at baseline and endpoint. The impact of almond form on particle size distribution (PSD) and predicted lipid release was measured in a subgroup (n = 31). RESULTS: Modified intention-to-treat analysis was performed on 79 participants. There were no significant differences in abundance of fecal bifidobacteria following consumption of whole almonds (8.7%, SD 7.7%), ground almonds (7.8%, SD 6.9%) or control (13.0%, SD 10.2%; q = 0.613). Consumption of almonds (whole and ground pooled) resulted in higher butyrate (24.1 μmol/g, SD 15.0 μmol/g) in comparison to control (18.2 μmol/g, SD 9.1 μmol/g; p = 0.046). There was no effect of almonds on gut microbiota at the phylum level or diversity, gut transit time, stool consistency or gut symptoms. Almond form (whole versus ground) had no effect on study outcomes. Ground almonds resulted in significantly smaller PSD and higher predicted lipid release (10.4%, SD 1.8%) in comparison to whole almonds (9.3%, SD 2.0%; p = 0.017). CONCLUSIONS: Almond consumption has limited impact on g
AU  - Creedon,AC
AU  - Dimidi,E
AU  - Hung,ES
AU  - Rossi,M
AU  - Probert,C
AU  - Grassby,T
AU  - Miguens-Blanco,J
AU  - Marchesi,JR
AU  - Scott,SM
AU  - Berry,SE
AU  - Whelan,K
DO  - ajcn/nqac265
EP  - 1804
PY  - 2022///
SN  - 0002-9165
SP  - 1790
TI  - The impact of almonds and almond processing on gastrointestinal physiology, luminal mand gastrointestinal symptoms: a randomized controlled trial and mastication study.
T2  - American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1093/ajcn/nqac265
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36130222
UR  - https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqac265/6708364
UR  - http://hdl.handle.net/10044/1/99824
VL  - 116
ER  -
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