Imperial College London
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ProfessorJamilMayet

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 1006j.mayet

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

NHLI offices,Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Ramakrishnan:2021:10.1136/heartjnl-2021-BCS.179,
author = {Ramakrishnan, A and Shah, A and Thom, S and Sharp, A and Francis, D and Stanton, A and Poulter, N and Sever, P and Hughes, A and Mayet, J},
doi = {10.1136/heartjnl-2021-BCS.179},
pages = {A140--A142},
publisher = {BMJ Publishing Group},
title = {182Tissue doppler E’ velocity and E/e’ predict 19-year cardiovascular mortality in hypertension},
url = {http://dx.doi.org/10.1136/heartjnl-2021-BCS.179},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Background We have previously shown that tissue Doppler assessments of left ventricular (LV) diastolic function predict cardiac events in a hypertensive population over a period of 4 years. These out-performed traditional echocardiographic measures in a well-treated hypertensive population.Purpose We aimed to test whether tissue Doppler assessment of LV diastolic function would predict cardiovascular (CV) mortality in the Hypertension Associated Cardiovascular Disease sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).Methods ASCOT was a multicentre randomised trial with a 2x2 factorial design. Inclusion criteria for the study included hypertension and three other CV risk factors, including male sex and age over 55. Protocols, including for echocardiography, have been detailed previously.This study comprised the 519 patients recruited to the St Mary’s Hospital site of the ASCOT study, who were followed for a median of 19 years with mortality flagged by the Office for National Statistics. We have used all reported deaths on or before 31st January 2019. CV deaths include deaths due to coronary heart disease (CHD), stroke and other CV causes. Echocardiography was performed one year after blood pressure control. mean tissue Doppler E’ was calculated as the average of septal, lateral and inferior wall measurements over three cycles. The ratio of the transmitral Doppler E wave velocity and the composite mean of E’ was used to calculate E/E’ ratio. Statistical analysis was performed using Python including multivariable Cox proportional hazards regression. A two-sided P-value <0.05 was considered statistically significant.Results After a median of 19 years (±5 years), 317 patients survived (mean age at baseline 60y, 38 female) and 202 did not (mean age 68y, 30 female). Twenty-three deaths were due to CHD, 11 were due to stroke, 27 were due to other CV causes, and 76 were due to cancer. Baseline characteristics were not signi
AU  - Ramakrishnan,A
AU  - Shah,A
AU  - Thom,S
AU  - Sharp,A
AU  - Francis,D
AU  - Stanton,A
AU  - Poulter,N
AU  - Sever,P
AU  - Hughes,A
AU  - Mayet,J
DO  - 10.1136/heartjnl-2021-BCS.179
EP  - 142
PB  - BMJ Publishing Group
PY  - 2021///
SN  - 1355-6037
SP  - 140
TI  - 182Tissue doppler E’ velocity and E/e’ predict 19-year cardiovascular mortality in hypertension
UR  - http://dx.doi.org/10.1136/heartjnl-2021-BCS.179
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000720867600182&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://heart.bmj.com/content/107/Suppl_1/A140.2
UR  - http://hdl.handle.net/10044/1/93893
ER  -
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