Imperial College London
Alternate

Dr John McGinley

Faculty of Engineering, Department of Mechanical Engineering

Research Fellow
 
 
 
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Contact

 

j.mcginley

 
 
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Location

 

122City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Paley:2001:10.1002/1522-2586(200101)13:1<127::AID-JMRI1019>3.3.CO;2-B,
author = {Paley, M and Mayhew, JE and Martindale, AJ and McGinley, J and Berwick, J and Coffey, P and Redgrave, P and Furness, P and Port, M and Ham, A and Zheng, Y and Jones, M and Whitby, E and Van, Beek EJR and Wilkinson, ID and Darwent, G and Griffiths, PD},
doi = {10.1002/1522-2586(200101)13:1<127::AID-JMRI1019>3.3.CO;2-B},
journal = {Journal of Magnetic Resonance Imaging},
pages = {87--92},
title = {Design and initial evaluation of a low-cost 3-Tesla research system for combined optical and functional MR imaging with interventional capability},
url = {http://dx.doi.org/10.1002/1522-2586(200101)13:1<127::AID-JMRI1019>3.3.CO;2-B},
volume = {13},
year = {2001}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A 3-Tesla research system has been developed for functional and interventional magnetic resonance imaging (MRI) procedures on animal models based on a low field niche spectrometer. Use of two stages of fourth harmonic frequency multiplication has allowed us to produce a high-frequency spectrometer with good frequency stability based on a low-frequency direct digital synthesizer. The system has been designed with the ability to introduce interventional tools such as biopsy needles, radiofrequency (RF) electrodes, and fiber optics for optical spectroscopy and thermal ablation as well as drug infusions to allow function to be studied in the presence of external challenges. Full MR-compatible physiologic support capability allows animals to be maintained in a stable condition over extended periods of study. Functional MR images have been acquired by using gradient echoes (TR/TE = 40/12 msec) from the rat whisker barrel cortex using electrical stimulation (5-V, 1.5-mA, 1-msec pulses at 5 Hz via two needle electrodes inserted into the rat whisker pad). Initial results using respiratory gas challenges of 100% N2, 100% O2, and 10% CO2 have shown excellent agreement between single wavelength (633 nm) optical and functional MR time series with sub-second time resolution. The 1-mm copper electrodes for interventional radiofrequency ablation procedures were easily visualized in the superior colliculus by using gradient echo sequences. This novel, low-cost, high field system appears to be a useful research tool for functional and interventional studies of rat brain and allows concurrent optical spectroscopy. © 2001 Wiley-Liss, Inc.
AU  - Paley,M
AU  - Mayhew,JE
AU  - Martindale,AJ
AU  - McGinley,J
AU  - Berwick,J
AU  - Coffey,P
AU  - Redgrave,P
AU  - Furness,P
AU  - Port,M
AU  - Ham,A
AU  - Zheng,Y
AU  - Jones,M
AU  - Whitby,E
AU  - Van,Beek EJR
AU  - Wilkinson,ID
AU  - Darwent,G
AU  - Griffiths,PD
DO  - 10.1002/1522-2586(200101)13:1<127::AID-JMRI1019>3.3.CO;2-B
EP  - 92
PY  - 2001///
SN  - 1053-1807
SP  - 87
TI  - Design and initial evaluation of a low-cost 3-Tesla research system for combined optical and functional MR imaging with interventional capability
T2  - Journal of Magnetic Resonance Imaging
UR  - http://dx.doi.org/10.1002/1522-2586(200101)13:1<127::AID-JMRI1019>3.3.CO;2-B
VL  - 13
ER  -
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