Dr Jaya Nautiyal is a translational researcher in Department of Surgery and Cancer in Imperial College London. Her role is oriented to meet ambitious translational science objectives in international, multi-centre, gynae trials which are collaborative endeavors between academia and pharmaceutical industry.
The goal of Dr Nautiyal's research is to study hormonal and metabolic purtuberances that effect gene regulation in cancer, through studying hormonal receptors and associated coregulators in relation to the PI3K-mTOR pathway.Her work is focussed on understanding the pathophysiology of gynaecological cancers of the endometrium and ovary to identify biomarker driven stratified approaches to treat cancer.
Jaya received her post doctoral training in molecular endocrinology in the laboratory of Prof Malcolm Parker and is currently working with Prof Iain McNeish who is the Head of the Division of Cancer and Director of the Ovarian Cancer Action Research Centre.
et al., 2019, Risk factors for endometrial cancer: An umbrella review of the literature, International Journal of Cancer, Vol:145, ISSN:0020-7136, Pages:1719-1730
et al., 2018, LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca²+ entry, Journal of Molecular Medicine-jmm, Vol:96, ISSN:0946-2716, Pages:173-182
et al., 2017, WWOX sensitizes ovarian cancer cells to paclitaxel via modulation of the ER stress response, Cell Death & Disease, Vol:8, ISSN:2041-4889
Nautiyal J, 2017, Transcriptional coregulator RIP140: an essential regulator of physiology, Journal of Molecular Endocrinology, Vol:58, ISSN:1479-6813, Pages:R147-R158
et al., 2017, RISK FACTORS ASSOCIATED WITH ENDOMETRIAL CANCER: AN UMBRELLA REVIEW, LIPPINCOTT WILLIAMS & WILKINS, Pages:570-570, ISSN:1048-891X