Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

987 results found

BROWN RD, JONES G, WILLETT P, GLEN RCet al., 1994, MATCHING 2-DIMENSIONAL CHEMICAL GRAPHS USING GENETIC ALGORITHMS, JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, Vol: 34, Pages: 63-70, ISSN: 0095-2338

Journal article

CLARK DE, JONES G, WILLETT P, KENNY PW, GLEN RCet al., 1994, PHARMACOPHORIC PATTERN-MATCHING IN PILES OF 3-DIMENSIONAL CHEMICAL STRUCTURES - COMPARISON OF CONFORMATIONAL-SEARCHING ALGORITHMS FOR FLEXIBLE SEARCHING, JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, Vol: 34, Pages: 197-206, ISSN: 0095-2338

Journal article

ANTHONY ML, BEDDELL CR, LINDON JC, NICHOLSON JKet al., 1993, STUDIES ON THE EFFECTS OF L(ALPHA-S,5S)-ALPHA- AMINO-3-CHLORO-4,5-DIHYDRO-5-ISOXAZOLEACETIC ACID (AT-125) ON 4-AMINOPHENOL-INDUCED NEPHROTOXICITY IN THE FISCHER-344 RAT, ARCHIVES OF TOXICOLOGY, Vol: 67, Pages: 696-705, ISSN: 0340-5761

Journal article

SPRAUL M, HOFMANN M, WILSON ID, LENZ E, NICHOLSON JK, LINDON JCet al., 1993, COUPLING OF HPLC WITH F-19-NMR AND H-1-NMR SPECTROSCOPY TO INVESTIGATE THE HUMAN URINARY-EXCRETION OF FLURBIPROFEN METABOLITES, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 11, Pages: 1009-1015, ISSN: 0731-7085

Journal article

ANTHONY ML, BEDDELL CR, LINDON JC, NICHOLSON JKet al., 1993, RAISED TRANSAMINASE-ACTIVITY OF BLOOD-PLASMA FROM RATS WITH EXPERIMENTALLY-INDUCED KIDNEY DAMAGE DETECTED BY SPIN-ECHO H-1-NMR SPECTROSCOPY, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 11, Pages: 897-902, ISSN: 0731-7085

Journal article

Stamler R, Liu LS, Nichols R, Huang DX, Long ZP, Xie JX, Elliott Pet al., 1993, Blood pressure and life style in the People's Republic of China: three samples in the INTERSALT Study., J Hum Hypertens, Vol: 7, Pages: 429-435, ISSN: 0950-9240

In INTERSALT, the International Cooperative Study on Electrolytes and Blood Pressure, three centres located in the People's Republic of China (PRC) had distinctive patterns of BP and of life style variables that, in INTERSALT overall, were found to relate to BP. The PRC centres had low body mass index (BMI) and alcohol consumption but high urinary sodium and sodium/potassium ratio (Na/K). Compared with 45 other INTERSALT centres, average BMI was 22.7 vs. 25.4 and alcohol consumption was 32% vs. 61%, with heavy drinking 3% vs. 14%. However, Na/K in the PRC was 6.7 vs. 3.2 in the other centres. This combination of factors may underlie the BP pattern observed. While mean BP in the PRC was lower than in the 45 centres (-7.0 mmHg SBP, -5.6 mmHg for DBP), this was counterbalanced by other findings. Upward slope of systolic pressure with age was 45% greater for the PRC than the other centres and 24% greater for diastolic pressure. As a result, although percentage hypertensive for ages 20-49 years for the PRC was half that in the 45 centres (6% vs. 12%), by age 50-59 years the prevalence was 31% in the PRC and 38% in the other centres. Hypertension prevalence in Tianjin, with highest Na/K in INTERSALT (7.6) was 40% for ages 50-59 years. While sample size in individual centres does not provide power to demonstrate aetiological relationships, these findings permit formulation of the following hypothesis: although lower body mass and lower alcohol intake may counteract to some degree impact of high salt intake, such intake over decades eventually takes its toll on BP.

Journal article

CUPID BC, NICHOLSON JK, DAVIS P, RUANE RJ, WILSON ID, GLEN RC, ROSE VS, BEDDELL CR, LINDON JCet al., 1993, QUANTITATIVE STRUCTURE CHROMATOGRAPHY RELATIONSHIPS IN REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - PREDICTION OF RETENTION BEHAVIOR USING THEORETICALLY DERIVED MOLECULAR-PROPERTIES, CHROMATOGRAPHIA, Vol: 37, Pages: 241-249, ISSN: 0009-5893

Journal article

GHAURI FYK, MCLEAN AEM, BEALES D, WILSON ID, NICHOLSON JKet al., 1993, INDUCTION OF 5-OXOPROLINURIA IN THE RAT FOLLOWING CHRONIC FEEDING WITH N-ACETYL 4-AMINOPHENOL (PARACETAMOL), BIOCHEMICAL PHARMACOLOGY, Vol: 46, Pages: 953-957, ISSN: 0006-2952

Journal article

WILSON ID, NICHOLSON JK, HOFMANN M, SPRAUL M, LINDON JCet al., 1993, INVESTIGATION OF THE HUMAN METABOLISM OF ANTIPYRINE USING COUPLED LIQUID-CHROMATOGRAPHY AND NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY OF URINE, JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, Vol: 617, Pages: 324-328, ISSN: 0378-4347

Journal article

SWEATMAN BC, FARRANT RD, HOLMES E, GHAURI FY, NICHOLSON JK, LINDON JCet al., 1993, 600 MHZ H-1-NMR SPECTROSCOPY OF HUMAN CEREBROSPINAL-FLUID - EFFECTS OF SAMPLE MANIPULATION AND ASSIGNMENT OF RESONANCES, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 11, Pages: 651-664, ISSN: 0731-7085

Journal article

FARRANT RD, SALMAN SR, LINDON JC, CUPID BC, NICHOLSON JKet al., 1993, DEUTERIUM NMR-SPECTROSCOPY OF BIOFLUIDS FOR THE IDENTIFICATION OF DRUG METABOLITES - APPLICATION TO N,N-DIMETHYLFORMAMIDE, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 11, Pages: 687-692, ISSN: 0731-7085

Journal article

POWELL JJ, GREENFIELD SM, PARKES HG, NICHOLSON JK, THOMPSON RPHet al., 1993, GASTROINTESTINAL AVAILABILITY OF ALUMINUM FROM TEA, FOOD AND CHEMICAL TOXICOLOGY, Vol: 31, Pages: 449-454, ISSN: 0278-6915

Journal article

PAYNE AWR, GLEN RC, 1993, MOLECULAR RECOGNITION USING A BINARY GENETIC SEARCH ALGORITHM, JOURNAL OF MOLECULAR GRAPHICS, Vol: 11, Pages: 74-&, ISSN: 0263-7855

Journal article

GHAURI FYK, PARKES HG, NICHOLSON JK, WILSON ID, BRENTON DPet al., 1993, ASYMPTOMATIC 5-OXOPROLINURIA DETECTED BY PROTON MAGNETIC-RESONANCE SPECTROSCOPY, CLINICAL CHEMISTRY, Vol: 39, Pages: 1341-1341, ISSN: 0009-9147

Journal article

FOXALL PJD, SPRAUL M, FARRANT RD, LINDON LC, NEILD GH, NICHOLSON JKet al., 1993, 750 MHZ 1H-NMR SPECTROSCOPY OF HUMAN BLOOD-PLASMA, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 11, Pages: 267-276, ISSN: 0731-7085

Journal article

BARRACLOUGH P, BLACK JW, CAMBRIDGE D, GERSKOWITCH VP, GILES H, GLEN RC, HULL RAD, IYER R, KING WR, NOBBS MS, RANDALL P, SHAH GP, STONE D, VINE SJ, WHITING MVet al., 1993, SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF BW315C AND OTHER INOTROPIC 2-ARYLIMIDAZO[1,2-A]PYRAZINES, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 3, Pages: 509-514, ISSN: 0960-894X

Journal article

GHAURI FYK, NICHOLSON JK, SWEATMAN BC, WOOD J, BEDDELL CR, LINDON JC, CAIRNS NJet al., 1993, NMR-SPECTROSCOPY OF HUMAN POSTMORTEM CEREBROSPINAL-FLUID - DISTINCTION OF ALZHEIMERS-DISEASE FROM CONTROL USING PATTERN-RECOGNITION AND STATISTICS, NMR IN BIOMEDICINE, Vol: 6, Pages: 163-167, ISSN: 0952-3480

Journal article

SPRAUL M, HOFMANN M, DVORTSAK P, NICHOLSON JK, WILSON IDet al., 1993, HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY COUPLED TO HIGH-FIELD PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY - APPLICATION TO THE URINARY METABOLITES OF IBUPROFEN, ANALYTICAL CHEMISTRY, Vol: 65, Pages: 327-330, ISSN: 0003-2700

Journal article

BARRACLOUGH P, CALDWELL AG, GLEN RC, HARRIS CJ, STEPNEY R, WHITTAKER N, WHITTLE BJRet al., 1993, SYNTHESIS AND PLATELET-AGGREGATION INHIBITING ACTIVITY OF ACID SIDE-CHAIN MODIFIED HYDANTOIN PROSTAGLANDIN ANALOGS, ARCHIV DER PHARMAZIE, Vol: 326, Pages: 85-95, ISSN: 0365-6233

Journal article

FOXALL PJD, MELLOTTE GJ, BENDING MR, LINDON JC, NICHOLSON JKet al., 1993, NMR-SPECTROSCOPY AS A NOVEL-APPROACH TO THE MONITORING OF RENAL-TRANSPLANT FUNCTION, KIDNEY INTERNATIONAL, Vol: 43, Pages: 234-245, ISSN: 0085-2538

Journal article

FOXALL PJD, PARKINSON JA, SADLER IH, LINDON JC, NICHOLSON JKet al., 1993, ANALYSIS OF BIOLOGICAL-FLUIDS USING 600 MHZ PROTON NMR-SPECTROSCOPY - APPLICATION OF HOMONUCLEAR 2-DIMENSIONAL J-RESOLVED SPECTROSCOPY TO URINE AND BLOOD-PLASMA FOR SPECTRAL SIMPLIFICATION AND ASSIGNMENT, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 11, Pages: 21-31, ISSN: 0731-7085

Journal article

Spraul M, Hofmann M, Lindon JC, Nicholson JK, Wilson ID, Morden W, Jackson P, Wilkins JPG, Tetler LW, Cooper P, Kane M, Dean JR, Hitchen SM, Dowle CJ, Tranter RLet al., 1993, Hyphenated methods, Analytical Proceedings, Vol: 30, Pages: 390-400, ISSN: 0144-557X

Journal article

SALMAN SR, FARRANT RD, GLEN RC, LINDON JCet al., 1993, CONFORMATIONAL FLEXIBILITY OF N-FORMYLMORPHOLINE STUDIED USING VARIABLE-TEMPERATURE C-13 NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS CALCULATIONS, SPECTROSCOPY LETTERS, Vol: 26, Pages: 745-749, ISSN: 0038-7010

Journal article

Pirkle WH, Welch CJ, Burke JA, Lamm B, Camilleri P, Schurig V, Jung M, Mayer S, Schmalzing D, Schleimer M, Taylor A, Blackledge CA, Nicholson JK, Williams DAR, Wilson ID, Ariƫns EJet al., 1992, Chirality, Analytical Proceedings, Vol: 29, Pages: 225-234, ISSN: 0144-557X

Journal article

GHAURI FY, BLACKLEDGE CA, GLEN RC, SWEATMAN BC, LINDON JC, BEDDELL CR, WILSON ID, NICHOLSON JKet al., 1992, QUANTITATIVE STRUCTURE METABOLISM RELATIONSHIPS FOR SUBSTITUTED BENZOIC-ACIDS IN THE RAT - COMPUTATIONAL CHEMISTRY, NMR-SPECTROSCOPY AND PATTERN-RECOGNITION STUDIES, BIOCHEMICAL PHARMACOLOGY, Vol: 44, Pages: 1935-1946, ISSN: 0006-2952

Journal article

HOLMES E, BONNER FW, SWEATMAN BC, LINDON JC, BEDDELL CR, RAHR E, NICHOLSON JKet al., 1992, NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY AND PATTERN-RECOGNITION ANALYSIS OF THE BIOCHEMICAL PROCESSES ASSOCIATED WITH THE PROGRESSION OF AND RECOVERY FROM NEPHROTOXIC LESIONS IN THE RAT INDUCED BY MERCURY(II) CHLORIDE AND 2-BROMOETHANAMINE, MOLECULAR PHARMACOLOGY, Vol: 42, Pages: 922-930, ISSN: 0026-895X

Journal article

HOLMES E, NICHOLSON JK, BONNER FW, SWEATMAN BC, BEDDELL CR, LINDON JC, RAHR Eet al., 1992, MAPPING THE BIOCHEMICAL TRAJECTORY OF NEPHROTOXICITY BY PATTERN-RECOGNITION OF NMR URINALYSIS, NMR IN BIOMEDICINE, Vol: 5, Pages: 368-372, ISSN: 0952-3480

Journal article

ANTHONY ML, GARTLAND KPR, BEDDELL CR, LINDON JC, NICHOLSON JKet al., 1992, CEPHALORIDINE-INDUCED NEPHROTOXICITY IN THE FISCHER-344 RAT - PROTON NMR SPECTROSCOPIC STUDIES OF URINE AND PLASMA IN RELATION TO CONVENTIONAL CLINICAL CHEMICAL AND HISTOPATHOLOGICAL ASSESSMENTS OF NEPHRONAL DAMAGE, ARCHIVES OF TOXICOLOGY, Vol: 66, Pages: 525-537, ISSN: 0340-5761

Journal article

SANINS SM, TIMBRELL JA, ELCOMBE C, NICHOLSON JKet al., 1992, PROTON NMR SPECTROSCOPIC STUDIES ON THE METABOLISM AND BIOCHEMICAL EFFECTS OF HYDRAZINE INVIVO, ARCHIVES OF TOXICOLOGY, Vol: 66, Pages: 489-495, ISSN: 0340-5761

Journal article

RAZZAK MA, GLEN RC, 1992, APPLICATIONS OF RULE-INDUCTION IN THE DERIVATION OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, Vol: 6, Pages: 349-383, ISSN: 0920-654X

Journal article

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