Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

986 results found

Fernstad SJ, Glen RC, 2014, Visual Analysis of Missing Data - To See What Isn't There, IEEE Conference Visual Analytics Sci Technology, Publisher: IEEE, Pages: 249-250, ISSN: 2325-9442

Conference paper

Cai Y, Blangiardo M, De Hoogh K, Gulliver J, Morley D, Doiron D, Elliott P, Hansell A, Hodgson Set al., 2014, Road traffic noise, air pollution and cardio-respiratory health in European cohorts: A harmonised approach in the BioSHaRE project

Background and aims: Few studies have investigated joint effects of road traffic noise and air pollution on cardiovascular outcomes. This project aims to quantify the joint and separate effects of both exposures on prevalent and incident cardiovascular disease and asthma as part of the EU-funded BioSHaRE project involving five European cohorts (EPIC-Oxford, EPIC-Turin, HUNT, Lifelines, UK Biobank). Methods: Health outcomes have been ascertained by self-report (prevalence) and medical record (incidence) and retrospectively harmonised across the five cohorts. Residential road traffic noise exposures for each participant are being estimated using a European noise model based on Common Noise Assessment Methods in Europe (CNOSSOS-EU). Cross-sectional epidemiological analyses are in progress, virtually pooled using DataSHIELD methods. Results: In total, 716,945 men and women are included, mostly >40 years. Initial analysis of EPIC-Oxford and Lifelines showed prevalence of self-reported hypertension to be 26%, high blood lipids 15% and asthma 11% and mean annual 24-hour noise estimates of 56.4 dB(A) (EPIC-Oxford) and 65.8 dB(A) (Lifelines). Correlations between noise estimates and NO2 are generally low (r~0.1 to 0.4). Conclusions: Pooling of individual level harmonised data from established cohorts offers the large sample sizes needed to investigate effects of road traffic noise and ambient air pollution on cardio-respiratory diseases.

Conference paper

Hansell AL, Blangiardo M, Fortunato L, Floud S, De Hoogh K, Fecht D, Ghosh RE, Laszlo HE, Pearson C, Beale L, Beevers S, Gulliver J, Best N, Richardson S, Elliott Pet al., 2014, Daytime and night-time aircraft noise and cardiovascular disease near Heathrow airport in London

Background. Few studies have investigated associations of aircraft noise with cardiovascular health. We investigated this in areas exposed to noise from London Heathrow airport. Methods. A small area study was conducted in 12,110 census output areas covering 3.6 million residents. Risks for hospital admissions and mortality in 2001-05 were assessed in relation to aircraft noise in 2001, adjusted for relevant confounders. Night (Lnight) and daytime (LAeq,16h) aircraft noise were assessed separately. Results. Higher aircraft noise was associated with higher relative risks for hospital admissions and mortality from stroke, coronary heart disease (CHD) and cardiovascular disease. Risk estimates were higher for night-time than daytime noise. Adjusted risks werehighest for stroke, with RR 1.29 [95% CI 1.14 to 1.46] for Lnight and RR 1.08 [95% CI 1.02 to 1.14] for LAeq,16hfor >55dB vs. <50dB. All linear dose-response relationships were statistically significant for hospital admissions but not for mortality, except for CHD and LAeq,16h. Discussion. This research attracted a high level of policy interest. However, the impact of this and other recent papers on policy decisions such as increased airport capacity in England is currently unclear. Priority areas for follow-up health research into aircraft noise need to be considered.

Conference paper

Liggi S, Drakakis G, Koutsoukas A, Cortes-Ciriano I, Martinez-Alonso P, Malliavin TE, Velazquez-Campoy A, Brewerton SC, Bodkin MJ, Evans DA, Glen RC, Alberto Carrodeguas J, Bender Aet al., 2014, Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts, FUTURE MEDICINAL CHEMISTRY, Vol: 6, Pages: 2029-2056, ISSN: 1756-8919

Journal article

Dumas M-E, Kinross J, Nicholson JK, 2014, Metabolic Phenotyping and Systems Biology Approaches to Understanding Metabolic Syndrome and Fatty Liver Disease, GASTROENTEROLOGY, Vol: 146, Pages: 46-62, ISSN: 0016-5085

Journal article

Stamler J, Brown IJ, Yap IKS, Chan Q, Wijeyesekera A, Garcia-Perez I, Chadeau-Hyam M, Ebbels TMD, De Iorio M, Posma J, Daviglus ML, Carnethon M, Holmes E, Nicholson JK, Elliott Pet al., 2013, Dietary and Urinary Metabonomic Factors Possibly Accounting for Higher Blood Pressure of Black Compared With White Americans Results of International Collaborative Study on Macro-/Micronutrients and Blood Pressure, HYPERTENSION, Vol: 62, Pages: 1074-1080, ISSN: 0194-911X

Journal article

Posma JM, Robinette SL, Holmes E, Nicholson JKet al., 2013, MetaboNetworks, an interactive Matlab-based toolbox for creating, customizing and exploring sub-networks from KEGG, Bioinformatics

MetaboNetworks is a tool to create custom sub-networks in Matlab using main reaction pairs as defined by the Kyoto Encyclopaedia of Genes and Genomes (KEGG) and can be used to explore transgenomic interactions, for example mammalian and bacterial associations. It calculates the shortest path between a set of metabolites (e.g. biomarkers from a metabonomic study) and plots the connectivity between metabolites as links in a network graph. The resulting graph can be edited and explored interactively. Furthermore, nodes and edges in the graph are linked to the KEGG compound and reaction pair webpages.

Journal article

Nguyen HP, Koutsoukas A, Fauzi FM, Drakakis G, Maciejewski M, Glen RC, Bender Aet al., 2013, Diversity Selection of Compounds Based on 'Protein Affinity Fingerprints' Improves Sampling of Bioactive Chemical Space, CHEMICAL BIOLOGY & DRUG DESIGN, Vol: 82, Pages: 252-266, ISSN: 1747-0277

Journal article

Lazarus J, Safreed-Harmon K, Nicholson J, Jaffar Set al., 2013, Health service delivery models for the provision of antiretroviral therapy in sub-Saharan Africa: a systematic review, Publisher: WILEY-BLACKWELL, Pages: 17-17, ISSN: 1360-2276

Conference paper

Koutsoukas A, Lowe R, KalantarMotamedi Y, Mussa HY, Klaffke W, Mitchell JBO, Glen RC, Bender Aet al., 2013, In Silico Target Predictions: Defining a Benchmarking Data Set and Comparison of Performance of the Multiclass Naive Bayes and Parzen-Rosenblatt Window, JOURNAL OF CHEMICAL INFORMATION AND MODELING, Vol: 53, Pages: 1957-1966, ISSN: 1549-9596

Journal article

Balog J, Sasi-Szabo L, Kinross J, Lewis MR, Muirhead LJ, Veselkov K, Mirnezami R, Dezso B, Damjanovich L, Darzi A, Nicholson JK, Takats Zet al., 2013, Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry, SCIENCE TRANSLATIONAL MEDICINE, Vol: 5, ISSN: 1946-6234

Journal article

Athersuch TJ, Malik S, Weljie A, Newton J, Keun HCet al., 2013, Evaluation of H-1 NMR Metabolic Profiling Using Biofluid Mixture Design, ANALYTICAL CHEMISTRY, Vol: 85, Pages: 6674-6681, ISSN: 0003-2700

Journal article

Swann JR, Spagou K, Lewis M, Nicholson JK, Glei DA, Seeman TE, Coe CL, Goldman N, Ryff CD, Weinstein M, Holmes Eet al., 2013, Microbial-Mammalian Cometabolites Dominate the Age-associated Urinary Metabolic Phenotype in Taiwanese and American Populations, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 3166-3180, ISSN: 1535-3893

Journal article

Richards SE, Wang Y, Claus SP, Lawler D, Kochhar S, Holmes E, Nicholson JKet al., 2013, Metabolic Phenotype Modulation by Caloric Restriction in a Lifelong Dog Study, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 3117-3127, ISSN: 1535-3893

Journal article

Robinette SL, Lindon JC, Nicholson JK, 2013, Statistical Spectroscopic Tools for Biomarker Discovery and Systems Medicine, ANALYTICAL CHEMISTRY, Vol: 85, Pages: 5297-5303, ISSN: 0003-2700

Journal article

LI JV, Holmes E, 2013, Metabonomics, The Human Microbiota and Microbiome, Editors: Marchesi

Application of metabonomics to understanding gut microbiome and host metabolic interplay

Book chapter

Mirnezami R, Veselkov K, Strittmatter N, Kinross JM, Goldin RD, Speller A, Jones EA, Holmes E, Abramov T, Nicholson JK, Darzi AW, Takats Zet al., 2013, Novel data processing and image co-registration algorithm for region-specific lipid profiling in colorectal cancer tissue using DESI imaging mass spectrometry, 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X

Conference paper

Li J, Kinross J, Ou J, Carbonero F, Vipperla K, Ruder EH, Newton K, Naidoo VG, DeLany JP, Zoetendal EG, Gaskins HR, O'Keefe SJ, Nicholson JKet al., 2013, A High Fat Lower Fiber Dietary Intervention Perturbs the Urinary Metabonome and Gut Microbial Co-Metabolic Processes in a Population of African and African Americans, Digestive Disease Week / 28th Annual Residents and Fellows Research Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S348-S348, ISSN: 0016-5085

Conference paper

Zheng X, Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Jia W, Luther M, Su M, Nicholson JK, Jia Wet al., 2013, Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota (vol 5, 172ra22, 2013), SCIENCE TRANSLATIONAL MEDICINE, Vol: 5, ISSN: 1946-6234

Journal article

Lees HJ, Swann JR, Wilson ID, Nicholson JK, Holmes Eet al., 2013, Hippurate: The Natural History of a Mammalian-Microbial Cometabolite, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 1527-1546, ISSN: 1535-3893

Journal article

Boulange CL, Claus SP, Chou CJ, Collino S, Montoliu I, Kochhar S, Holmes E, Rezzi S, Nicholson JK, Dumas ME, Martin F-PJet al., 2013, Early Metabolic Adaptation in C57BL/6 Mice Resistant to High Fat Diet Induced Weight Gain Involves an Activation of Mitochondrial Oxidative Pathways, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 1956-1968, ISSN: 1535-3893

Journal article

Shalhoub J, Vorkas PA, Isaac G, Want EJ, McDonald S, Langridge J, Millar A, Shockcor JP, Nicholson JK, Davies AHet al., 2013, Metabolic profiling of human atherosclerosis tissue reveals mechanisms of atherosclerosis progression and differences between carotid and femoral plaques, 47th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 7-7, ISSN: 0007-1323

Conference paper

Chan Q, Stamler J, Posma J, Garcia I, Wijeyesekera A, Griep LO, Van Horn L, Daviglus ML, Miura K, Zhao L, Nicholson JK, Holmes E, Elliott Pet al., 2013, Relationship of Coffee Consumption and its Urinary Biomarker to Blood Pressure: The Intermap Study, Scientific Sessions of the American-Heart-Association on Epidemiology and Prevention/Physical Activity, Nutrition and Metabolism, Publisher: LIPPINCOTT WILLIAMS & WILKINS, ISSN: 0009-7322

Conference paper

Seyfried F, Li JV, Miras AD, Cluny NL, Lannoo M, Fenske WK, Sharkey KA, Nicholson JK, le Roux CW, Holmes Eet al., 2013, Urinary Phenotyping Indicates Weight Loss-Independent Metabolic Effects of Roux-en-Y Gastric Bypass in Mice, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 1245-1253, ISSN: 1535-3893

Journal article

Zheng X, Zhao A, Xie G, Chi Y, Zhao L, Li H, Wang C, Bao Y, Jia W, Luther M, Su M, Nicholson JK, Jia Wet al., 2013, Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota, SCIENCE TRANSLATIONAL MEDICINE, Vol: 5, ISSN: 1946-6234

Journal article

Fonville JM, Carter CL, Pizarro L, Steven RT, Palmer AD, Griffiths RL, Lalor PF, Lindon JC, Nicholson JK, Holmes E, Bunch Jet al., 2013, Hyperspectral Visualization of Mass Spectrometry Imaging Data, ANALYTICAL CHEMISTRY, Vol: 85, Pages: 1415-1423, ISSN: 0003-2700

Journal article

Jimenez B, Mirnezami R, Kinross J, Cloarec O, Keun HC, Holmes E, Goldin RD, Ziprin P, Darzi A, Nicholson JKet al., 2013, H-1 HR-MAS NMR Spectroscopy of Tumor-Induced Local Metabolic "Field-Effects" Enables Colorectal Cancer Staging and Prognostication, JOURNAL OF PROTEOME RESEARCH, Vol: 12, Pages: 959-968, ISSN: 1535-3893

Journal article

Kirchmair J, Howlett A, Peironcely JE, Murrell DS, Williamson MJ, Adams SE, Hankemeier T, van Buren L, Duchateau G, Klaffke W, Glen RCet al., 2013, How Do Metabolites Differ from Their Parent Molecules and How Are They Excreted?, JOURNAL OF CHEMICAL INFORMATION AND MODELING, Vol: 53, Pages: 354-367, ISSN: 1549-9596

Journal article

Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson JK, Knights D, Ursell LK, Knight R, Gordon JIet al., 2013, Gut microbiomes of Malawian twin pairs discordant for kwashiorkor, science.

Journal article

Nicholson J, 2013, Cancer knife sniffs out cancer cells (Science (221)), Science, Vol: 341, ISSN: 0036-8075

Journal article

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