Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

986 results found

Fonville JM, Carter C, Cloarec O, Nicholson JK, Lindon JC, Bunch J, Holmes Eet al., 2012, Robust Data Processing and Normalization Strategy for MALDI Mass Spectrometric Imaging, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 1310-1319, ISSN: 0003-2700

Journal article

Mestdagh R, Dumas M-E, Rezzi S, Kochhar S, Holmes E, Claus SP, Nicholson JKet al., 2012, Gut Microbiota Modulate the Metabolism of Brown Adipose Tissue in Mice, JOURNAL OF PROTEOME RESEARCH, Vol: 11, Pages: 620-630, ISSN: 1535-3893

Journal article

Nicholson JK, Everett JR, Lindon JC, 2012, Longitudinal pharmacometabonomics for predicting patient responses to therapy: drug metabolism, toxicity and efficacy, EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, Vol: 8, Pages: 135-139, ISSN: 1742-5255

Journal article

Cazier J-B, Kaisaki PJ, Argoud K, Blaise BJ, Veselkov K, Ebbels TMD, Tsang T, Wang Y, Bihoreau M-T, Mitchell SC, Holmes EC, Lindon JC, Scott J, Nicholson JK, Dumas M-E, Gauguier Det al., 2012, Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase, JOURNAL OF PROTEOME RESEARCH, Vol: 11, Pages: 631-642, ISSN: 1535-3893

Journal article

Lowe R, Mussa HY, Nigsch F, Glen RC, Mitchell JBOet al., 2012, Predicting the mechanism of phospholipidosis, JOURNAL OF CHEMINFORMATICS, Vol: 4, ISSN: 1758-2946

Journal article

Maher AD, Fonville JM, Coen M, Lindon JC, Rae CD, Nicholson JKet al., 2012, Statistical Total Correlation Spectroscopy Scaling for Enhancement of Metabolic Information Recovery in Biological NMR Spectra, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 1083-1091, ISSN: 0003-2700

Journal article

Marchesi JR, Li J, Holmes E, Ashrafian H, Athanasiou T, Darzi A, Nicholson JKet al., 2012, Reply, Gastroenterology, Vol: 142, Pages: 401-402, ISSN: 0016-5085

Journal article

Jaureguiberry G, De la Dure-Molla M, Parry D, Quentric M, Himmerkus N, Koike T, Poulter J, Klootwijk E, Robinette SL, Howie AJ, Patel V, Figueres M-L, Stanescu HC, Issler N, Nicholson JK, Bockenhauer D, Laing C, Walsh SB, McCredie DA, Povey S, Asselin A, Picard A, Coulomb A, Medlar AJ, Bailleul-Forestier I, Verloes A, Le Caignec C, Roussey G, Guiol J, Isidor B, Logan C, Shore R, Johnson C, Inglehearn C, Al-Bahlani S, Schmittbuhl M, Clauss F, Huckert M, Laugel V, Ginglinger E, Pajarola S, Sparta G, Bartholdi D, Rauch A, Addor M-C, Yamaguti PM, Safatle HP, Acevedo AC, Martelli-Junior H, dos Santos Netos PE, Coletta RD, Gruessel S, Sandmann C, Ruehmann D, Langman CB, Scheinman SJ, Ozdemir-Ozenen D, Hart TC, Hart PS, Neugebauer U, Schlatter E, Houillier P, Gahl WA, Vikkula M, Bloch-Zupan A, Bleich M, Kitagawa H, Unwin RJ, Mighell A, Berdal A, Kleta Ret al., 2012, Nephrocalcinosis (Enamel Renal Syndrome) Caused by Autosomal Recessive FAM20A Mutations, NEPHRON PHYSIOLOGY, Vol: 122, Pages: 1-6, ISSN: 1660-2137

Journal article

Glen RC, 2012, Computational chemistry and cheminformatics: an essay on the future, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, Vol: 26, Pages: 47-49, ISSN: 0920-654X

Journal article

Wijeyesekera A, Clarke PA, Bictash M, Brown IJ, Fidock M, Ryckmans T, Yap IKS, Chan Q, Stamler J, Elliott P, Holmes E, Nicholson JKet al., 2012, Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study, ANALYTICAL METHODS, Vol: 4, Pages: 65-72, ISSN: 1759-9660

Journal article

Li JV, Ashrafian H, Bueter M, Kinross J, Sands C, le Roux CW, Bloom SR, Darzi A, Athanasiou T, Marchesi JR, Nicholson JK, Holmes Eet al., 2012, Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk, Gut, Vol: 60, Pages: 1214-1223

Journal article

Veselkov KA, Vingara LK, Masson P, Robinette SL, Want E, Li JV, Barton RH, Boursier-Neyret C, Walther B, Ebbels TM, Pelczer I, Holmes E, Lindon JC, Nicholson JKet al., 2011, Response to Comment on "Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery", ANALYTICAL CHEMISTRY, Vol: 83, Pages: 9721-9722, ISSN: 0003-2700

Journal article

Zheng X, Xie G, Zhao A, Zhao L, Yao C, Chiu NHL, Zhou Z, Bao Y, Jia W, Nicholson JK, Jia Wet al., 2011, The Footprints of Gut Microbial-Mammalian Co-Metabolism, JOURNAL OF PROTEOME RESEARCH, Vol: 10, Pages: 5512-5522, ISSN: 1535-3893

Journal article

Rezzonico E, Mestdagh R, Delley M, Combremont S, Dumas M-E, Holmes E, Nicholson J, Bibiloni Ret al., 2011, Bacterial adaptation to the gut environment favors successful colonization: microbial and metabonomic characterization of a simplified microbiota mouse model., Gut Microbes, Vol: 2, Pages: 307-318

Rodent models harboring a simple yet functional human intestinal microbiota provide a valuable tool to study the relationships between mammals and their bacterial inhabitants. In this study, we aimed to develop a simplified gnotobiotic mouse model containing 10 easy-to-grow bacteria, readily available from culture repositories, and of known genome sequence, that overall reflect the dominant commensal bacterial makeup found in adult human feces. We observed that merely inoculating a mix of fresh bacterial cultures into ex-germ free mice did not guarantee a successful intestinal colonization of the entire bacterial set, as mice inoculated simultaneously with all strains only harbored 3 after 21 d. Therefore, several inoculation procedures were tested and levels of individual strains were quantified using molecular tools. Best results were obtained by inoculating single bacterial strains into individual animals followed by an interval of two weeks before allowing the animals to socialize to exchange their commensal microbes. Through this procedure, animals were colonized with almost the complete bacterial set (9/10). Differences in the intestinal composition were also reflected in the urine and plasma metabolic profiles, where changes in lipids, SCFA, and amino acids were observed. We conclude that adaptation of bacterial strains to the host's gut environment (mono-colonization) may predict a successful establishment of a more complex microbiota in rodents.

Journal article

Fonville JM, Bylesjoe M, Coen M, Nicholson JK, Holmes E, Lindon JC, Rantalainen Met al., 2011, Non-linear modeling of H-1 NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing, ANALYTICA CHIMICA ACTA, Vol: 705, Pages: 72-80, ISSN: 0003-2670

Journal article

Heinzmann SS, Merrifield CA, Rezzi S, Kochhar S, Lindon JC, Holmes E, Nicholson JKet al., 2011, Stability and Robustness of Human Metabolic Phenotypes in Response to Sequential Food Challenges, Journal of Proteome Research, Vol: 11, Pages: 643-655, ISSN: 1535-3893

Journal article

Chan ECY, Pasikanti KK, Nicholson JK, 2011, Global urinary metabolic profiling procedures using gas chromatography-mass spectrometry, NATURE PROTOCOLS, Vol: 6, Pages: 1483-1499, ISSN: 1754-2189

Journal article

Nicholson G, Rantalainen M, Li JV, Maher AD, Malmodin D, Ahmadi KR, Faber JH, Barrett A, Min JL, Rayner NW, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas M-E, Sarkans U, Donnelly P, Illig T, Adamski J, Suhre K, Allen M, Zondervan KT, Spector TD, Nicholson JK, Lindon JC, Baunsgaard D, Holmes E, McCarthy MI, Holmes CCet al., 2011, A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection, PLOS GENETICS, Vol: 7, ISSN: 1553-7404

Journal article

LI JV, Reshat R, Wu Q, Ashrafian H, Bueter M, le Roux CW, Darzi A, Athanasiou T, Marchesi JR, Nicholson JK, Holmes E, Gooderham NJet al., 2011, Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents, Frontiers in Microbiology, Vol: 2, Pages: 1-9

Journal article

Veselkov KA, Vingara LK, Masson P, Robinette SL, Want E, Li JV, Barton RH, Boursier-Neyret C, Walther B, Ebbels TM, Pelczer I, Holmes E, Lindon JC, Nicholson JKet al., 2011, Optimized Preprocessing of Ultra-Performance Liquid Chromatography/Mass Spectrometry Urinary Metabolic Profiles for Improved Information Recovery, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 5864-5872, ISSN: 0003-2700

Journal article

Nicholson G, Rantalainen M, Maher AD, Li JV, Malmodin D, Ahmadi KR, Faber JH, Hallgrimsdottir IB, Barrett A, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas M-E, Sarkans U, Silverman BW, Donnelly P, Nicholson JK, Allen M, Zondervan KT, Lindon JC, Spector TD, McCarthy MI, Holmes E, Baunsgaard D, Holmes CCet al., 2011, Human metabolic profiles are stably controlled by genetic and environmental variation, MOLECULAR SYSTEMS BIOLOGY, Vol: 7, ISSN: 1744-4292

Journal article

Ashrafian H, Li JV, Bueter M, le Roux CW, Bloom SR, Marchesi JR, Nicholson JK, Holmes E, Darzi A, Athanasiou Tet al., 2011, Metabolic Surgery Modulates the Systemic Metabolic Profile and Gut Microbial Ecology, 16th Congress of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), Publisher: SPRINGER, Pages: 1098-1098, ISSN: 0960-8923

Conference paper

Legido-Quigley C, McDermott L, Vilca-Melendez H, Murphy GM, Heaton N, Lindon JC, Nicholson JK, Holmes Eet al., 2011, Bile UPLC-MS fingerprinting and bile acid fluxes during human liver transplantation, ELECTROPHORESIS, Vol: 32, Pages: 2063-2070, ISSN: 0173-0835

Journal article

Swann JR, Tuohy KM, Lindfors P, Brown DT, Gibson GR, Wilson ID, Sidaway J, Nicholson JK, Holmes Eet al., 2011, Variation in Antibiotic-Induced Microbial Recolonization Impacts on the Host Metabolic Phenotypes of Rats, JOURNAL OF PROTEOME RESEARCH, Vol: 10, Pages: 3590-3603, ISSN: 1535-3893

Journal article

Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JKet al., 2011, Understanding the role of gut microbiome-host metabolic signal disruption in health and disease, TRENDS IN MICROBIOLOGY, Vol: 19, Pages: 349-359, ISSN: 0966-842X

Journal article

Lowe R, Mussa HY, Mitchell JBO, Glen RCet al., 2011, Classifying Molecules Using a Sparse Probabilistic Kernel Binary Classifier, JOURNAL OF CHEMICAL INFORMATION AND MODELING, Vol: 51, Pages: 1539-1544, ISSN: 1549-9596

Journal article

Macaluso NJM, Pitkin SL, Maguire JJ, Davenport AP, Glen RCet al., 2011, Discovery of a Competitive Apelin Receptor (APJ) Antagonist, CHEMMEDCHEM, Vol: 6, Pages: 1017-1023, ISSN: 1860-7179

Journal article

Shalhoub J, Vorkas PA, Monaco C, Want EJ, Lewis MR, Davies AH, Holmes E, Nicholson JKet al., 2011, COMPREHENSIVE METABOLIC PROFILING IN RISK STRATIFICATION OF HUMAN CAROTID ATHEROSCLEROSIS, 79th Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, Pages: 151-152, ISSN: 1567-5688

Conference paper

Patel VM, Ashrafian H, Ahmed K, Arora S, Jiwan S, Nicholson JK, Darzi A, Athanasiou Tet al., 2011, How has healthcare research performance been assessed? A systematic review, J R Soc Med1, Vol: 104, Pages: 251-261

Journal article

Stebbing J, Sharma A, North B, Athersuch TJ, Zebrowski A, Pchejetski D, Coombes RC, Nicholson JK, Keun HCet al., 2011, A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumor responses to chemotherapy., J Clin Oncol, Vol: 29

10544 Background: Breast cancer is associated with adverse outcomes in patients with the metabolic syndrome phenotype. We previously demonstrated using a metabolic profiling (metabonomics) approach that glucose, lactate and alanine levels were perturbed during chemotherapy and that these effects were associated with weight gain during treatment. To validate these data and study this further, we examined the relationship between serum metabolite levels and the components of metabolic syndrome with treatment outcomes in breast cancer. METHODS: A total of 88 women with measurable breast cancer were studied; their serum metabolites as assessed by 1H NMR spectroscopy, blood pressure, lipids, glucose, body mass index and waist circumference were recorded and correlated with treatment response. RESULTS: We identified metabolic syndrome in approximately half of our cohort (42 patients) and observed a significant trend (p=0.03) of increased incidence of metabolic syndrome in partial response (33.3%), stable disease (42.9%) and progressive disease groups (66.1%). Of the components of metabolic syndrome, high blood sugar predicted a poor response (p < 0.001). Logistic regression of metabonomic data demonstrated that high lactate (p=0.03) and low alanine (p=0.01), combined with high glucose (p=0.01) in the same sera, were associated with disease progression. CONCLUSIONS: Metabolic syndrome is commonly observed in women with metastatic breast cancer and these patients have poorer outcomes. These data, which support our previous findings suggest that high blood glucose as part of metabolic syndrome is associated with a poor response in breast cancer. They also validate new therapeutic approaches that focus on metabolism.

Journal article

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