Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry



+44 (0)20 7594 3195j.nicholson Website




Ms Wendy Torto +44 (0)20 7594 3225




Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus






BibTex format

author = {Seow, WJ and Shu, X and Nicholson, J and Holmes, E and Walker, DI and Hu, W and Cai, Q and Gao, Y-T and Xiang, Y-B and Moore, S and Bassig, BA and Wong, JYY and Zhang, J and Ji, B-T and Boulange, C and Kaluarachchi, M and Wijeyesekera, A and Zheng, W and Elliott, P and Rothman, N and Lan, Q},
doi = {10.1001/jamanetworkopen.2019.11970},
journal = {JAMA Network Open},
title = {Association of untargeted urinary metabolomics and lung cancer risk among never-smoking women in China.},
url = {},
volume = {2},
year = {2019}

RIS format (EndNote, RefMan)

AB - Importance Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood.Objective To assess the association between metabolomics and lung cancer risk among never-smoking women.Design, Setting, and Participants This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women’s Health Study recruited from December 28, 1996, to May 23, 2000. Validated food frequency questionnaires were used for the collection of dietary information. Metabolomic analysis was conducted from November 13, 2015, to January 6, 2016. Data analysis was conducted from January 6, 2016, to November 29, 2018.Exposures Untargeted ultra-high-performance liquid chromatography–tandem mass spectrometry and nuclear magnetic resonance metabolomic profiles were characterized using prediagnosis urine samples. A total of 39416 metabolites were measured.Main Outcomes and Measures Incident lung cancer.Results Among the 564 women, those who developed lung cancer (275 participants; median [interquartile range] age, 61.0 [52-65] years) and those who did not develop lung cancer (289 participants; median [interquartile range] age, 62.0 [53-66] years) at follow-up (median [interquartile range] follow-up, 10.9 [9.0-11.7] years) were similar in terms of their secondhand smoke exposure, history of respiratory diseases, and body mass index. A peak metabolite, identified as 5-methyl-2-furoic acid, was significantly associated with lower lung cancer risk (odds ratio, 0.57 [95% CI, 0.46-0.72]; P < .001; false discovery rate = 0.039). Furthermore, this peak was weakly correlated with self-reported dietary soy intake (ρ = 0.21; P < .001). Increasing tertiles of this metabolite were associated with lower lung cancer risk (in comparison with first tertile, odd
AU - Seow,WJ
AU - Shu,X
AU - Nicholson,J
AU - Holmes,E
AU - Walker,DI
AU - Hu,W
AU - Cai,Q
AU - Gao,Y-T
AU - Xiang,Y-B
AU - Moore,S
AU - Bassig,BA
AU - Wong,JYY
AU - Zhang,J
AU - Ji,B-T
AU - Boulange,C
AU - Kaluarachchi,M
AU - Wijeyesekera,A
AU - Zheng,W
AU - Elliott,P
AU - Rothman,N
AU - Lan,Q
DO - 10.1001/jamanetworkopen.2019.11970
PY - 2019///
SN - 2574-3805
TI - Association of untargeted urinary metabolomics and lung cancer risk among never-smoking women in China.
T2 - JAMA Network Open
UR -
UR -
VL - 2
ER -