Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wade:1990:10.1016/0731-7085(90)80067-Y,
author = {Wade, KE and Wilson, ID and Troke, JA and Nicholson, JK},
doi = {10.1016/0731-7085(90)80067-Y},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
pages = {401--410},
title = {<sup>19</sup>F and <sup>1</sup>H magnetic resonance strategies for metabolic studies on fluorinated xenobiotics: Application to flurbiprofen [2-(2-fluoro-4-biphenylyl)propionic acid]},
url = {http://dx.doi.org/10.1016/0731-7085(90)80067-Y},
volume = {8},
year = {1990}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Strategies for the use of 1H and 19F nuclear magnetic resonance (NMR) spectroscopy as an aid to the study of the metabolic fate of fluorinated drugs are discussed with reference to the application of these methods to flurbiprofen metabolism in man. 1H and 19F NMR analysis of untreated urine enabled the detection of two major and eight minor metabolites of the drug. The two major metabolites were identified using a combination of NMR spectroscopy, solid-phase extraction chromatography with 19F and 1H NMR detection and chemical hydrolysis to a flurbiprofen glucuronide and the glucuronide of the 4-hydroxy metabolite. 1H-19F 2D shift correlated spectroscopy and spin-echo difference experiments are discussed in relation to their use in the structural identification of drug metabolites. © 1990.
AU - Wade,KE
AU - Wilson,ID
AU - Troke,JA
AU - Nicholson,JK
DO - 10.1016/0731-7085(90)80067-Y
EP - 410
PY - 1990///
SN - 0731-7085
SP - 401
TI - <sup>19</sup>F and <sup>1</sup>H magnetic resonance strategies for metabolic studies on fluorinated xenobiotics: Application to flurbiprofen [2-(2-fluoro-4-biphenylyl)propionic acid]
T2 - Journal of Pharmaceutical and Biomedical Analysis
UR - http://dx.doi.org/10.1016/0731-7085(90)80067-Y
VL - 8
ER -