Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nicholson:1984,
author = {Nicholson, JK and Osborn, D and Kendall, MD},
journal = {Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
pages = {249--256},
title = {Comparative distributions of zinc, cadmium and mercury in the tissues of experimental mice.},
volume = {77},
year = {1984}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Different groups of mice were injected with cadmium, zinc and mercury. Zinc injections had no effect on zinc tissue levels while both mercury and cadmium accumulated in various tissues. Cadmium persisted in the tissues much longer than mercury, and while the mercury concentrations began to decline as soon as dosing ceased, cadmium concentrations in kidney and intestine increased even after dosing ceased. There appeared to be an interrelationship between cadmium concentrations in spleen and intestine which warrants some further investigations. There was a linear, but discontinuous, effect of cadmium on zinc concentrations in liver, kidney and pancreas which may depend on metallothionein biochemistry. Mercury injections had no effect on zinc metabolism. It is proposed that differences in the rate of excretion of cadmium and mercury from the kidney could explain the differential accumulation of cadmium and mercury in animals.
AU - Nicholson,JK
AU - Osborn,D
AU - Kendall,MD
EP - 256
PY - 1984///
SN - 0742-8413
SP - 249
TI - Comparative distributions of zinc, cadmium and mercury in the tissues of experimental mice.
T2 - Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
VL - 77
ER -