Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wilson:2016:10.1016/j.trsl.2016.08.002,
author = {Wilson, ID and Nicholson, JK},
doi = {10.1016/j.trsl.2016.08.002},
journal = {Translational Research},
pages = {204--222},
title = {Gut microbiome interactions with drug metabolism, efficacy, and toxicity},
url = {http://dx.doi.org/10.1016/j.trsl.2016.08.002},
volume = {179},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The gut microbiota has both direct and indirect effects on drug and xenobiotic metabolisms, and this can have consequences for both efficacy and toxicity. Indeed, microbiome-driven drug metabolism is essential for the activation of certain prodrugs, for example, azo drugs such as prontosil and neoprontosil resulting in the release of sulfanilamide. In addition to providing a major source of reductive metabolizing capability, the gut microbiota provides a suite of additional reactions including acetylation, deacylation, decarboxylation, dehydroxylation, demethylation, dehalogenation, and importantly, in the context of certain types of drug-related toxicity, conjugates hydrolysis reactions. In addition to direct effects, the gut microbiota can affect drug metabolism and toxicity indirectly via, for example, the modulation of host drug metabolism and disposition and competition of bacterial-derived metabolites for xenobiotic metabolism pathways. Also, of course, the therapeutic drugs themselves can have effects, both intended and unwanted, which can impact the health and composition of the gut microbiota with unforeseen consequences.
AU - Wilson,ID
AU - Nicholson,JK
DO - 10.1016/j.trsl.2016.08.002
EP - 222
PY - 2016///
SN - 1931-5244
SP - 204
TI - Gut microbiome interactions with drug metabolism, efficacy, and toxicity
T2 - Translational Research
UR - http://dx.doi.org/10.1016/j.trsl.2016.08.002
UR - http://hdl.handle.net/10044/1/41044
VL - 179
ER -