Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Korecka:2016:10.1038/npjbiofilms.2016.14,
author = {Korecka, A and Dona, A and Lahiri, S and Tett, AJ and Al-Asmakh, M and Braniste, V and D'Arienzo, R and Abbaspour, A and Reichardt, N and Fujii-Kuriyama, Y and Rafter, J and Narbad, A and Holmes, E and Nicholson, J and Arulampalam, V and Pettersson, S},
doi = {10.1038/npjbiofilms.2016.14},
journal = {npj Biofilms and Microbiomes},
pages = {16014--16014},
title = {Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism.},
url = {http://dx.doi.org/10.1038/npjbiofilms.2016.14},
volume = {2},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The ligand-induced transcription factor, aryl hydrocarbon receptor (AhR) is known for its capacity to tune adaptive immunity and xenobiotic metabolism-biological properties subject to regulation by the indigenous microbiome. The objective of this study was to probe the postulated microbiome-AhR crosstalk and whether such an axis could influence metabolic homeostasis of the host. Utilising a systems-biology approach combining in-depth 1H-NMR-based metabonomics (plasma, liver and skeletal muscle) with microbiome profiling (small intestine, colon and faeces) of AhR knockout (AhR-/-) and wild-type (AhR+/+) mice, we assessed AhR function in host metabolism. Microbiome metabolites such as short-chain fatty acids were found to regulate AhR and its target genes in liver and intestine. The AhR signalling pathway, in turn, was able to influence microbiome composition in the small intestine as evident from microbiota profiling of the AhR+/+ and AhR-/- mice fed with diet enriched with a specific AhR ligand or diet depleted of any known AhR ligands. The AhR-/- mice also displayed increased levels of corticosterol and alanine in serum. In addition, activation of gluconeogenic genes in the AhR-/- mice was indicative of on-going metabolic stress. Reduced levels of ketone bodies and reduced expression of genes involved in fatty acid metabolism in the liver further underscored this observation. Interestingly, exposing AhR-/- mice to a high-fat diet showed resilience to glucose intolerance. Our data suggest the existence of a bidirectional AhR-microbiome axis, which influences host metabolic pathways.
AU - Korecka,A
AU - Dona,A
AU - Lahiri,S
AU - Tett,AJ
AU - Al-Asmakh,M
AU - Braniste,V
AU - D'Arienzo,R
AU - Abbaspour,A
AU - Reichardt,N
AU - Fujii-Kuriyama,Y
AU - Rafter,J
AU - Narbad,A
AU - Holmes,E
AU - Nicholson,J
AU - Arulampalam,V
AU - Pettersson,S
DO - 10.1038/npjbiofilms.2016.14
EP - 16014
PY - 2016///
SN - 2055-5008
SP - 16014
TI - Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism.
T2 - npj Biofilms and Microbiomes
UR - http://dx.doi.org/10.1038/npjbiofilms.2016.14
UR - http://hdl.handle.net/10044/1/55193
VL - 2
ER -