Imperial College London

Emeritus ProfessorJeremyNicholson

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Elliott:1994,
author = {Elliott, P},
pages = {595--601},
title = {Nutritional factors in blood pressure.},
url = {https://www.ncbi.nlm.nih.gov/pubmed/7990088},
year = {1994}
}

RIS format (EndNote, RefMan)

TY  - CPAPER
AB - High sodium intake, low potassium intake, high body mass index and high alcohol intake are established risk factors for high blood pressure (BP) in populations. For sodium, an overview of randomised controlled trials gave the estimate that reduction in sodium of around 70 mmol per day lowered BP on average by 2.9 mmHg systolic and 1.6 mmHg diastolic. An overview of within-population epidemiological studies (excluding INTERSALT), with correction for regression dilution, gave a pooled (simple) regression estimate that 100 mmol lower sodium was associated with BP lower by 4.5 mmHg systolic and 2.5 mmHg diastolic. In INTERSALT, across centres, average sodium excretion was significantly related to slope of BP with age, such that 100 mmol lower sodium was associated with 10 mmHg lower rise in SBP over 30 years; among individuals, previous estimates of the size of relationships of sodium and potassium to BP in INTERSALT were too low because of insufficient correction for the 'regression dilution' problem. For sodium, revised corrected regression estimates, with adjustment for age and sex, were 4.3 mmHg/100 mmol for SBP and 1.8 mmHg/100 mmol for DBP. After adjustment for other confounders, the corrected SBP-sodium regression estimate was 3.1 mmHg/100 mmol; it was 6.0 mmHg/100 mmol if body mass index was excluded from the regression model. The revised multiply adjusted regression estimate for SBP and potassium was -0.67 mmHg/10 mmol. Body mass index was positively related to BP in INTERSALT, consistent with other studies; on average, regression coefficients indicated 3.0 mmHg lower SBP and 2.2 mmHg lower DBP, for body weight lower by 10 kg.(ABSTRACT TRUNCATED AT 250 WORDS)
AU - Elliott,P
EP - 601
PY - 1994///
SN - 0950-9240
SP - 595
TI - Nutritional factors in blood pressure.
UR - https://www.ncbi.nlm.nih.gov/pubmed/7990088
ER -